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492030 NS 2028 - CAS 204326-43-2 - Calbiochem

Potent, specific, and irreversible inhibitor of soluble guanylyl cyclase.

NS 2028 - CAS 204326-43-2 - Calbiochem: のSDS（安全データシート）、CoA（試験成績書）およびCoQ（品質証明書）、カタログなど製品関連の技術資料を入手いただけます。

同義語: 4H-8-Bromo-1,2,4-oxadiazolo(3,4-d)benz(b)(1,4)oxazin-1-one

Primary Target: basal soluble guanylyl cyclase
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492030
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概要

Replacement Information

主要スペック表

CAS #Empirical Formula
204326-43-2C₉H₅BrN₂O₃

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492030-5MGCN
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      		 樹脂ｱﾝﾌﾟﾙ 5 mg
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      Description
      OverviewPotent, specific, and irreversible inhibitor of soluble guanylyl cyclase (IC50 = 30 nM for basal and 200 nM for NO-stimulated enzyme activity; IC50 = 17 nM for S-nitrosoglutathione-enhanced soluble guanylyl cyclase activity in homogenates of mouse cerebellum).
      Catalogue Number492030
      Brand Family Calbiochem®
      Synonyms4H-8-Bromo-1,2,4-oxadiazolo(3,4-d)benz(b)(1,4)oxazin-1-one
      References
      ReferencesFleming, I., et al. 1999. Proc. Natl. Acad. Sci. USA 96, 1123.
      Olesen, S.P., et al. 1998. Br. J. Pharmacol. 123, 299.
      Product Information
      CAS number204326-43-2
      ATP CompetitiveN
      FormWhite to off-white solid
      Hill FormulaC₉H₅BrN₂O₃
      Chemical formulaC₉H₅BrN₂O₃
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary Targetbasal soluble guanylyl cyclase
      Primary Target IC<sub>50</sub>30 nM for basal and 200 nM for NO-stimulated enzyme activity; 17 nM for S-nitrosoglutathione-enhanced soluble guanylyl cyclase activity in homogenates of mouse cerebellum
      Purity≥98% by NMR
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Moisture Protect from moisture
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C) for long-term storage. DMSO stock solutions are stable for up to 1 month at -20°C and for ~8 h at 4°C. Avoid freeze/thaw cycles of solutions.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      カタログ番号 GTIN
      492030-5MGCN 04055977273557

      Documentation

      NS 2028 - CAS 204326-43-2 - Calbiochem (M)SDS

      タイトル

      英語版製品安全データシート（(M)SDS） 

      NS 2028 - CAS 204326-43-2 - Calbiochem 試験成績書（CoA）

      タイトルロット番号
      492030

      参考資料

      参考資料の概要
      Fleming, I., et al. 1999. Proc. Natl. Acad. Sci. USA 96, 1123.
      Olesen, S.P., et al. 1998. Br. J. Pharmacol. 123, 299.

      カタログ

      タイトル
      Pathways and Biomarkers of Oxidative Stress
      データシート

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision07-April-2008 RFH
      Synonyms4H-8-Bromo-1,2,4-oxadiazolo(3,4-d)benz(b)(1,4)oxazin-1-one
      DescriptionPotent, specific, and irreversible inhibitor of soluble guanylyl cyclase (IC50 = 30 nM for basal and 200 nM for NO-stimulated enzyme activity; IC50 = 17 nM for S-nitrosoglutathione-enhanced soluble guanylyl cyclase activity in homogenates of mouse cerebellum).
      FormWhite to off-white solid
      CAS number204326-43-2
      Chemical formulaC₉H₅BrN₂O₃
      Structure formulaStructure formula
      Purity≥98% by NMR
      SolubilityDMSO (5 mg/ml), Ethanol (5 mg/ml), or CHCl₃ (1 mg/ml)
      Storage Protect from moisture
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C) for long-term storage. DMSO stock solutions are stable for up to 1 month at -20°C and for ~8 h at 4°C. Avoid freeze/thaw cycles of solutions.
      Toxicity Standard Handling
      ReferencesFleming, I., et al. 1999. Proc. Natl. Acad. Sci. USA 96, 1123.
      Olesen, S.P., et al. 1998. Br. J. Pharmacol. 123, 299.