Millipore Sigma Vibrant Logo

480450 NFF-2 - Calbiochem

A quenched fluorescence substrate for MMPs.

NFF-2 - Calbiochem: のSDS（安全データシート）、CoA（試験成績書）およびCoQ（品質証明書）、カタログなど製品関連の技術資料を入手いただけます。

同義語: MCA-RPKPYANvaWMK(DNP)-NH₂

View This Product on Sigma-Aldrich
480450
価格＆在庫状況を照会

概要

Replacement Information

価格＆在庫状況

カタログ番号 在庫状況包装 Qty/Pk 価格 数量
480450-1MGCN
在庫状況検索中…
—
現在国内在庫なし 現在国内在庫なし
現在国内在庫有り 
販売中止
在庫僅少
現在国内在庫あり
    Remaining : Will advise
      Remaining : Will advise
      注文対象外
      お問合せください
      Contact Customer Service

      		 樹脂ｱﾝﾌﾟﾙ 1 mg
      価格を検索中…
      価格が見つかりません
      Minimum Quantity needs to be mulitiple of
      Maximum Quantity is
      弊社照会 詳細を表示　
      値引
      ()
       
      —
      弊社照会
      		 —
      Description
      OverviewA quenched fluorescence substrate for MMPs. MMP-3 (stromelysin-1) hydrolyzes this substrate (kcat/Km = 5.9 x 104 M-1sec-1) at a rate 60 times faster than the hydrolysis by MMP-1 (interstitial collagenase). NFF-2 shows little discrimination between MMP-3, MMP-2 (gelatinase-A; kcat/Km = 5 x 104 M-1s-1), and MMP-9 (gelatinase-B; kcat/Km = 5.5 x 104 M-1s-1).
      Supplied as a trifluoroacetate salt.
      Catalogue Number480450
      Brand Family Calbiochem®
      SynonymsMCA-RPKPYANvaWMK(DNP)-NH₂
      References
      ReferencesNagase, H., et al. 1994. J. Biol. Chem. 269, 20952.
      Product Information
      ATP CompetitiveN
      FormLyophilized yellow solid
      FormulationSupplied as a trifluoroacetate salt.
      Hill FormulaC₇₉H₁₀₅N₁₉O₁₉S
      Chemical formulaC₇₉H₁₀₅N₁₉O₁₉S
      ReversibleN
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetMatrix Metalloproteinases (MMPs)
      Primary Target IC<sub>50</sub>kcat/Km = 5.9 x 104 M-1sec-1 as substrates for MMP-3 (stromelysin-1)
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableN
      Emission max.
      Excitation max.
      Peptide SequenceMCA-Arg-Pro-Lys-Pro-Tyr-Ala-Nva-Trp-Met-Lys(DNP)-NH₂ (DNP = 2,4-dinitrophenyl; Nva = L-norvaline)
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Protect from Moisture Protect from moisture
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      カタログ番号 GTIN
      480450-1MGCN 04055977201376

      Documentation

      NFF-2 - Calbiochem (M)SDS

      タイトル

      英語版製品安全データシート（(M)SDS） 

      NFF-2 - Calbiochem 試験成績書（CoA）

      タイトルロット番号
      480450

      参考資料

      参考資料の概要
      Nagase, H., et al. 1994. J. Biol. Chem. 269, 20952.
      データシート

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision11-August-2008 RFH
      SynonymsMCA-RPKPYANvaWMK(DNP)-NH₂
      DescriptionA quenched fluorescent substrate for MMPs (excitation maximum: ~325 nm; emission maximum: ~393 nm). MMP-3 (stromelysin-1) hydrolyzes this substrate (kcat/Km = 59,400 M-1s-1) at a rate 60X faster than hydrolysis by MMP-1 (interstitial collagenase). NFF-2 shows little discrimination between MMP-3, MMP-2 (gelatinase-A; kcat/Km = 54,000 M-1s-1), and MMP-9 (gelatinase-B; kcat/Km = 55,300 M-1s-1).
      FormLyophilized yellow solid
      FormulationSupplied as a trifluoroacetate salt.
      Chemical formulaC₇₉H₁₀₅N₁₉O₁₉S
      Peptide SequenceMCA-Arg-Pro-Lys-Pro-Tyr-Ala-Nva-Trp-Met-Lys(DNP)-NH₂ (DNP = 2,4-dinitrophenyl; Nva = L-norvaline)
      Purity≥98% by HPLC
      SolubilityDMSO (5 mg/ml)
      Storage Protect from moisture
      Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesNagase, H., et al. 1994. J. Biol. Chem. 269, 20952.