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480402 NFAT Inhibitor - CAS 249537-73-3 - Calbiochem

The NFAT Inhibitor controls the biological activity of NFAT. This small molecule/inhibitor is primarily used for Inflammation/Immunology applications.

NFAT Inhibitor - CAS 249537-73-3 - Calbiochem: のSDS（安全データシート）、CoA（試験成績書）およびCoQ（品質証明書）、カタログなど製品関連の技術資料を入手いただけます。

同義語: MAGPHPVIVITGPHEE

Primary Target: NFAT (Nuclear Factor of Activated T-cells)
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480402
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概要

Replacement Information

主要スペック表

CAS #Empirical Formula
249537-73-3C₇₅H₁₁₈N₂₀O₂₂S

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480402-500UGCN
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      		 樹脂ｱﾝﾌﾟﾙ 500 μg
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      Description
      OverviewA highly selective NFAT (Nuclear Factor of Activated T-cells) inhibitor that interferes with calcineurin-NFAT interaction without affecting calcineurin (Cat. No. 539568) phosphatase activity. Inhibits NFAT activation and NFAT-dependent expression of endogenous cytokine genes in T cells, without affecting the expression of other cytokines that require calcineurin but not NFAT.
      Catalogue Number480402
      Brand Family Calbiochem®
      SynonymsMAGPHPVIVITGPHEE
      References
      ReferencesNoguchi, H., et al. 2004. Nat. Med. 10, 305.
      Kiani, A., et al. 2001. Blood 98, 1480.
      Aramburu, J., et al. 1999. Science 285, 2129.
      Product Information
      CAS number249537-73-3
      ATP CompetitiveN
      FormLyophilized solid
      FormulationSupplied as a trifluoroacetate salt.
      Hill FormulaC₇₅H₁₁₈N₂₀O₂₂S
      Chemical formulaC₇₅H₁₁₈N₂₀O₂₂S
      Hygroscopic Hygroscopic
      ReversibleN
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetNFAT (Nuclear Factor of Activated T-cells)
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableN
      Peptide SequenceH-Met-Ala-Gly-Pro-His-Pro-Val-Ile-Val-Ile-Thr-Gly-Pro-His-Glu-Glu-OH
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C). Avoid freeze/thaw cycles of solutions.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      カタログ番号 GTIN
      480402-500UGCN 07790788050658

      Documentation

      NFAT Inhibitor - CAS 249537-73-3 - Calbiochem (M)SDS

      タイトル

      英語版製品安全データシート（(M)SDS） 

      NFAT Inhibitor - CAS 249537-73-3 - Calbiochem 試験成績書（CoA）

      タイトルロット番号
      480402

      参考資料

      参考資料の概要
      Noguchi, H., et al. 2004. Nat. Med. 10, 305.
      Kiani, A., et al. 2001. Blood 98, 1480.
      Aramburu, J., et al. 1999. Science 285, 2129.
      データシート

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision11-August-2008 RFH
      SynonymsMAGPHPVIVITGPHEE
      DescriptionA highly selective NFAT inhibitor that prevents NFAT activation and NFAT-dependent expression of endogenous cytokine genes in T cells. Does not affect the expression of other cytokines requiring calcineurin, but not NFAT. Inhibits calcineurin-mediated dephosphorylation of NFAT1, NFAT2, and NFAT4 in cell extracts.
      FormLyophilized solid
      FormulationSupplied as a trifluoroacetate salt.
      Intert gas (Yes/No) Packaged under inert gas
      CAS number249537-73-3
      Chemical formulaC₇₅H₁₁₈N₂₀O₂₂S
      Peptide SequenceH-Met-Ala-Gly-Pro-His-Pro-Val-Ile-Val-Ile-Thr-Gly-Pro-His-Glu-Glu-OH
      Purity≥95% by HPLC
      SolubilityH₂O
      Storage -20°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C). Avoid freeze/thaw cycles of solutions.
      Toxicity Standard Handling
      ReferencesNoguchi, H., et al. 2004. Nat. Med. 10, 305.
      Kiani, A., et al. 2001. Blood 98, 1480.
      Aramburu, J., et al. 1999. Science 285, 2129.