数量	カタログ番号	注文内容	Qty/Pk	価格
			96-Well Plate

数量	カタログ番号	注文内容	Qty/Pk	価格
	48-602MAG	Buffer Detection Kit for Magnetic Beads	1 Kit

480418 Sigma-AldrichNF279 - CAS 202983-32-2 - Calbiochem

A suramin analog that acts as a highly selective, competitive, and reversible ATP-antagonist of P2X receptor (IC₅₀/KB ~ 1 µM in smooth muscle).

NF279 - CAS 202983-32-2 - Calbiochem: のSDS（安全データシート）、CoA（試験成績書）およびCoQ（品質証明書）、カタログなど製品関連の技術資料を入手いただけます。

(M)SDS
試験成績書（CoA）
参考資料
Data Sheet

同義語: 8,8ʹ-(Carbonylbis(imino-4,1-phenylenecarbonylimino-4,1-phenylenecarbonylimino))bis-1,3,5-naphthalenetrisulfonic Acid, Na

Primary Target: P2X receptor

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概要

Replacement Information

主要スペック表

CAS #	Empirical Formula
202983-32-2	C₄₉H₃₀N₆O₂₃S₆ · 6Na

価格＆在庫状況

カタログ番号	在庫状況	包装	Qty/Pk	価格	数量
480418-5MGCN	在庫状況検索中… — 現在国内在庫なし現在国内在庫有り販売中止在庫僅少現在国内在庫あり在庫を照会するにはログインしてください現在国内在庫有り現在国内在庫なし現在国内在庫有り Remaining : Will advise Remaining : Will advise 注文対象外お問合せください Contact Customer Service お問合せくださいお問合せください	樹脂ｱﾝﾌﾟﾙ	5 mg	価格を検索中… 価格が見つかりません Minimum Quantity needs to be mulitiple of Maximum Quantity is 弊社照会詳細を表示　値引 () — 弊社照会納入価格を閲覧するにはログインしてください	在庫状況を照会 —	お気に入り/ショッピングリストに追加お気に入り/ショッピングリストに追加お気に入りに追加されました

Description
Overview	A suramin analog that acts as a highly selective, competitive, and reversible ATP-antagonist of P2X receptor (IC₅₀/K_B ~ 1 µM in smooth muscle). Effectively discriminates between P2Y and P2X receptors with no effect on α_1A adrenoceptors, adenosine A₁ and A_2B receptors, histamine H₁, muscarinic M₃ and neuronal nicotinic acetylcholine receptors. Displays a selectivity profile of P2X₁ >P2X₂ >P2X₃ >P2X₄ (IC₅₀ = 19 nM, 770 nM, 1.62 µM and >300 µM, respectively) in Xenopus oocytes pre-incubated with ATP. In rat and human tissues, exhibits a potency profile of rat P2X₁ > human P2X₁ > > rat P2X₂ > rat P2X₃ ~ human P2X₇ > > human P2X₄. Not degraded by ecto-nucleotidases.
Catalogue Number	480418
Brand Family	Calbiochem®
Synonyms	8,8ʹ-(Carbonylbis(imino-4,1-phenylenecarbonylimino-4,1-phenylenecarbonylimino))bis-1,3,5-naphthalenetrisulfonic Acid, Na

References
References	Klapperstück, M., et al. 2000. Eur. J. Pharmacol. 387, 245. Rettinger, J., et al. 2000. Neuropharmacol. 39, 2044. Lambrecht, G., et al. 1999. Prog. Brain Res. 120,107. Damer, S., et al. 1998. Eur. J. Pharmacol. 350, R5.

Product Information
CAS number	202983-32-2
ATP Competitive	Y
Form	White solid
Hill Formula	C₄₉H₃₀N₆O₂₃S₆ · 6Na
Chemical formula	C₄₉H₃₀N₆O₂₃S₆ · 6Na
Reversible	Y
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Primary Target	P2X receptor
Primary Target IC<sub>50</sub>	~ 1 µM as antagonist of P2X receptor in smooth muscle; 19 nM, 770 nM, 1.62 µM and <300 µM, against P2X1, P2X2, P2X3, P2X4, respectively, in Xenopus oocytes pre-incubated with ATP
Purity	≥99% by HPLC

Physicochemical Information
Cell permeable	Y

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Standard Handling
Storage	+2°C to +8°C
Protect from Light	Protect from light
Protect from Moisture	Protect from moisture
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
カタログ番号	GTIN
480418-5MGCN	04055977201352

Documentation

NF279 - CAS 202983-32-2 - Calbiochem (M)SDS

タイトル
英語版製品安全データシート（(M)SDS）

NF279 - CAS 202983-32-2 - Calbiochem 試験成績書（CoA）

タイトル	ロット番号
480418	ロット番号を入力

参考資料

参考資料の概要
Klapperstück, M., et al. 2000. Eur. J. Pharmacol. 387, 245. Rettinger, J., et al. 2000. Neuropharmacol. 39, 2044. Lambrecht, G., et al. 1999. Prog. Brain Res. 120,107. Damer, S., et al. 1998. Eur. J. Pharmacol. 350, R5.

データシート

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	11-August-2008 RFH
Synonyms	8,8ʹ-(Carbonylbis(imino-4,1-phenylenecarbonylimino-4,1-phenylenecarbonylimino))bis-1,3,5-naphthalenetrisulfonic Acid, Na
Description	A suramin analog that acts as a highly selective, competitive, and reversible ATP-antagonist of P2X receptor (IC₅₀/K_B ~1 µM in smooth muscle). Effectively discriminates between P2Y and P2X receptors with no discernible effects on α_1A adrenoceptors, adenosine A₁ and A_2B receptors, histamine H₁, muscarinic M₃ and neuronal nicotinic acetylcholine receptors. Displays a selectivity profile of P2X₁ >P2X₂ >P2X₃ >P2X₄ (IC₅₀ = 19 nM, 770 nM, 1.62 µM and >300 µM, respectively) in Xenopus oocytes pre-incubated with ATP. In rat and human tissues, exhibits a potency profile of rat P2X₁ > human P2X₁ » rat P2X₂ > rat P2X₃ ~human P2X₇ » human P2X₄. Not degraded by ecto-nucleotidases.
Form	White solid
Intert gas (Yes/No)	Packaged under inert gas
CAS number	202983-32-2
Chemical formula	C₄₉H₃₀N₆O₂₃S₆ · 6Na
Structure formula
Purity	≥99% by HPLC
Solubility	DMSO (14 mg/ml) or H₂O (35 mg/ml)
Storage	Protect from moisture Protect from light +2°C to +8°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
Toxicity	Standard Handling
References	Klapperstück, M., et al. 2000. Eur. J. Pharmacol. 387, 245. Rettinger, J., et al. 2000. Neuropharmacol. 39, 2044. Lambrecht, G., et al. 1999. Prog. Brain Res. 120,107. Damer, S., et al. 1998. Eur. J. Pharmacol. 350, R5.

カテゴリー

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Neurochemicals > Antagonists > Adenosine/Purinergic Receptor Antagonists

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