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481412 NF-kB Activation Inhibitor IV - CAS 139141-12-1 - Calbiochem

The NF-kB Activation Inhibitor IV, also referenced under CAS 139141-12-1, controls the biological activity of NF-kB. This small molecule/inhibitor is primarily used for Inflammation/Immunology applications.

NF-kB Activation Inhibitor IV - CAS 139141-12-1 - Calbiochem: のSDS（安全データシート）、CoA（試験成績書）およびCoQ（品質証明書）、カタログなど製品関連の技術資料を入手いただけます。

同義語: (E)-2-Fluoro-4ʹ-methoxystilbene

Primary Target: NF-κB Activation
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481412
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概要

Replacement Information

主要スペック表

CAS #Empirical Formula
139141-12-1C₁₅H₁₃FO

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481412-10MGCN
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      		 樹脂ｱﾝﾌﾟﾙ 10 mg
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      Description
      OverviewA cell-permeable trans-stilbene Resveratrol (Cat. No. 554325) analog that exhibits much enhanced anti-inflammatory potency, but no anti-oxidant activity. Suppresses LPS-induced COX-2 mRNA expression in BV-2 cells (~46% inhibition at 150 nM) and Shown to be ~130-fold more potent than Resveratrol in inhibiting TNF-α-stimulated NF-κB reporter activity in 293T cells (IC50 = 150 nM).
      Catalogue Number481412
      Brand Family Calbiochem®
      Synonyms(E)-2-Fluoro-4ʹ-methoxystilbene
      References
      ReferencesHeynekamp, J.J., et al. 2006. J. Med. Chem. 49, 7182.
      Product Information
      CAS number139141-12-1
      ATP CompetitiveN
      FormCrystalline solid
      Hill FormulaC₁₅H₁₃FO
      Chemical formulaC₁₅H₁₃FO
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetNF-κB Activation
      Primary Target IC<sub>50</sub>150 nM inhibiting TNF-α-stimulated NF-κB reporter activity in 293T cells.
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      カタログ番号 GTIN
      481412-10MGCN 04055977183726

      Documentation

      NF-kB Activation Inhibitor IV - CAS 139141-12-1 - Calbiochem (M)SDS

      タイトル

      英語版製品安全データシート（(M)SDS） 

      NF-kB Activation Inhibitor IV - CAS 139141-12-1 - Calbiochem 試験成績書（CoA）

      タイトルロット番号
      481412

      参考資料

      参考資料の概要
      Heynekamp, J.J., et al. 2006. J. Med. Chem. 49, 7182.
      データシート

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision26-July-2011 RFH
      Synonyms(E)-2-Fluoro-4ʹ-methoxystilbene
      DescriptionA cell-permeable trans-stilbene Resveratrol (Cat. No. 554325) analog that exhibits much enhanced anti-inflammatory potency, but no anti-oxidant activity. Suppresses LPS-induced COX-2 mRNA expression in BV-2 cells (~46% inhibition at 150 nM) and Shown to be ~130-fold more potent than Resveratrol in inhibiting TNF-α-stimulated NF-κB reporter activity in 293T cells (IC50 = 150 nM).
      FormCrystalline solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number139141-12-1
      Chemical formulaC₁₅H₁₃FO
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (20 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesHeynekamp, J.J., et al. 2006. J. Med. Chem. 49, 7182.