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481480 NF-κB SN50, Cell-Permeable Inhibitor Peptide - Calbiochem

NF-κB SN50, CAS 213546-43-3, is a cell-permeable peptide that contains the NLS sequence of NF-κB p50 linked to the hydrophobic region of K-FGF. Inhibits translocation of the NF-κB into the nucleus.

NF-κB SN50, Cell-Permeable Inhibitor Peptide - Calbiochem: のSDS（安全データシート）、CoA（試験成績書）およびCoQ（品質証明書）、カタログなど製品関連の技術資料を入手いただけます。

同義語: AAVALLPAVLLALLAPVQRKRQKLMP, NF-κB Activation Inhibitor VIII

Primary Target: translocation of the NF-κB active complex into the nucleus
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481480
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概要

Replacement Information

主要スペック表

Empirical Formula
C₁₂₉H₂₃₀N₃₆O₂₉S

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481480-1MGCN
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      		 樹脂ｱﾝﾌﾟﾙ 1 mg
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      481480-500UGCN
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          		 樹脂ｱﾝﾌﾟﾙ 500 μg
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          Description
          OverviewContains the nuclear localization sequence (NLS) of the transcription factor NF-κB p50 linked to the hydrophobic region (h-region) of the signal peptide of Kaposi fibroblast growth factor (K-FGF). The N-terminal K-FGF h-region confers cell-permeability, while the NLS (360-369) inhibits translocation of the NF-κB active complex into the nucleus. In murine endothelial LE-II cells induced by LPS, NF-κB nuclear translocation is maximally inhibited at 18 µM.
          Catalogue Number481480
          Brand Family Calbiochem®
          SynonymsAAVALLPAVLLALLAPVQRKRQKLMP, NF-κB Activation Inhibitor VIII
          References
          ReferencesLin, Y.-Z., et al. 1995. J. Biol. Chem. 270, 14255.
          Product Information
          ATP CompetitiveN
          DeclarationSold under license of U.S. Patents 5,807,746 and 6,043,339 for research use only. Licenses for commercial manufacture, commercial use, diagnostics, or therapeutics may be obtained by contacting Vanderbilt University, Nashville, Tennessee.
          FormLyophilized
          FormulationSupplied as a trifluoroacetate salt.
          Hill FormulaC₁₂₉H₂₃₀N₃₆O₂₉S
          Chemical formulaC₁₂₉H₂₃₀N₃₆O₂₉S
          Hygroscopic Hygroscopic
          ReversibleN
          Sold on the basis of peptide contentY
          Quality LevelMQ100
          Applications
          Biological Information
          Primary Targettranslocation of the NF-κB active complex into the nucleus
          Purity≥97% by HPLC
          Physicochemical Information
          Cell permeableY
          Peptide ContentY
          Peptide SequenceH-Ala-Ala-Val-Ala-Leu-Leu-Pro-Ala-Val-Leu-Leu-Ala-Leu-Leu-Ala-Pro-Val-Gln-Arg-Lys-Arg-Gln-Lys-Leu-Met-Pro-OH
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. Avoid freeze/thaw cycles of solutions.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications
          Global Trade Item Number
          カタログ番号 GTIN
          481480-1MGCN 04055977183771
          481480-500UGCN 04055977183788

          Documentation

          NF-κB SN50, Cell-Permeable Inhibitor Peptide - Calbiochem (M)SDS

          タイトル

          英語版製品安全データシート（(M)SDS） 

          NF-κB SN50, Cell-Permeable Inhibitor Peptide - Calbiochem 試験成績書（CoA）

          タイトルロット番号
          481480

          参考資料

          参考資料の概要
          Lin, Y.-Z., et al. 1995. J. Biol. Chem. 270, 14255.

          カタログ

          タイトル
          Pathways and Biomarkers of Toll-like Receptor (TLR) Signaling

          引用

          Title
        • Teresa Sanchez Alcaraz, et al. (2004) Involvement of Glutathione as a Mechanism of Indirect Protection against Spontaneous Ex Vivo Apoptosis Associated with Bovine Leukemia Virus. Journal of Virology 78, 6180-6190.
          		•
          データシート

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision03-March-2008 JSW
          SynonymsAAVALLPAVLLALLAPVQRKRQKLMP, NF-κB Activation Inhibitor VIII
          DescriptionContains the nuclear localization sequence (NLS) of the transcription factor NF-κB p50 linked to the hydrophobic region (h-region) of the signal peptide of Kaposi fibroblast growth factor (K-FGF). The peptide N-terminal K-FGF h-region confers cell-permeability, while the NLS (360-369) inhibits translocation of the NF-κB active complex into the nucleus. In murine endothelial LE-II cells induced by LPS, inhibition of NF-κB nuclear translocation is maximally inhibited at 18 µM.
          FormLyophilized
          FormulationSupplied as a trifluoroacetate salt.
          Chemical formulaC₁₂₉H₂₃₀N₃₆O₂₉S
          Peptide SequenceH-Ala-Ala-Val-Ala-Leu-Leu-Pro-Ala-Val-Leu-Leu-Ala-Leu-Leu-Ala-Pro-Val-Gln-Arg-Lys-Arg-Gln-Lys-Leu-Met-Pro-OH
          Purity≥97% by HPLC
          SolubilityH₂O (5 mg/ml)
          Storage -20°C
          Hygroscopic
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. Avoid freeze/thaw cycles of solutions.
          Toxicity Standard Handling
          ReferencesLin, Y.-Z., et al. 1995. J. Biol. Chem. 270, 14255.
          Citation
        • Teresa Sanchez Alcaraz, et al. (2004) Involvement of Glutathione as a Mechanism of Indirect Protection against Spontaneous Ex Vivo Apoptosis Associated with Bovine Leukemia Virus. Journal of Virology 78, 6180-6190.
          		•