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681660 N-WASP-Inhibitor, 187-1 - CAS 380488-27-7 - Calbiochem

The N-WASP-Inhibitor, 187-1 controls the biological activity of neural Wiskott Aldrich syndrome protein (N-WASP). This small molecule/inhibitor is primarily used for Cell Structure applications.

N-WASP-Inhibitor, 187-1 - CAS 380488-27-7 - Calbiochem: のSDS（安全データシート）、CoA（試験成績書）およびCoQ（品質証明書）、カタログなど製品関連の技術資料を入手いただけます。

同義語: cyclo(LKDFDPDFLFDPLQ)₂

Primary Target: Neural Wiskott Aldrich syndrome protein (N-WASP)
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681660
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概要

Replacement Information

主要スペック表

CAS #Empirical Formula
380488-27-7C₉₆H₁₂₂N₁₈O₁₆

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681660-1MGCN
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      Description
      OverviewA 14-amino acid cyclic peptide that potently blocks phosphatidylinositol 4,5-bisphosphate (PIP2)-induced actin assembly in Xenopus egg cytoplasmic extract (IC50 ~ 2 µM). Shown to directly bind to neural Wiskott Aldrich syndrome protein (N-WASP) with high-affinity, and prevent the activation of actin-related protein 2/3 (Arp2/3) complex by inhibiting the interaction between N-WASP and Arp2/3.
      Catalogue Number681660
      Brand Family Calbiochem®
      Synonymscyclo(LKDFDPDFLFDPLQ)₂
      References
      ReferencesPeterson, J.R., et al. 2001. Proc. Natl. Acad. Sci. USA 98, 10624.
      Suetsugu, S., et al. 2001. J. Biol. Chem. 276, 33175.
      Product Information
      CAS number380488-27-7
      ATP CompetitiveN
      FormWhite lyophilized solid
      FormulationSupplied as a trifluoroacetate salt.
      Hill FormulaC₉₆H₁₂₂N₁₈O₁₆
      Chemical formulaC₉₆H₁₂₂N₁₈O₁₆
      Hygroscopic Hygroscopic
      ReversibleN
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetNeural Wiskott Aldrich syndrome protein (N-WASP)
      Primary Target IC<sub>50</sub>~ 2 µM blocking phosphatidylinositol 4,5-bisphosphate (PIP2)-induced actin assembly in Xenopus egg cytoplasmic extract
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableN
      Peptide Sequencecyclo(LLys-DPhe-DPro-DPhe-LPhe-DPro-LGln)₂
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      カタログ番号 GTIN
      681660-1MGCN 04055977260212

      Documentation

      N-WASP-Inhibitor, 187-1 - CAS 380488-27-7 - Calbiochem (M)SDS

      タイトル

      英語版製品安全データシート（(M)SDS） 

      N-WASP-Inhibitor, 187-1 - CAS 380488-27-7 - Calbiochem 試験成績書（CoA）

      タイトルロット番号
      681660

      参考資料

      参考資料の概要
      Peterson, J.R., et al. 2001. Proc. Natl. Acad. Sci. USA 98, 10624.
      Suetsugu, S., et al. 2001. J. Biol. Chem. 276, 33175.
      データシート

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision16-September-2008 RFH
      Synonymscyclo(LKDFDPDFLFDPLQ)₂
      DescriptionA 14-amino acid cyclic peptide that potently blocks phosphatidylinositol 4,5-bisphosphate (PIP2)-induced actin assembly in Xenopus egg cytoplasmic extract (IC50 ~2 µM). Shown to directly bind to neural Wiskott Aldrich syndrome protein (N-WASP) with high-affinity, and allosterically stabilize the autoinhibited conformation of N-WASP. It prevents the activation of actin-related protein 2/3 (Arp2/3) complex by blocking the interaction between N-WASP and Arp2/3.
      FormWhite lyophilized solid
      FormulationSupplied as a trifluoroacetate salt.
      Intert gas (Yes/No) Packaged under inert gas
      CAS number380488-27-7
      Chemical formulaC₉₆H₁₂₂N₁₈O₁₆
      Peptide Sequencecyclo(LLys-DPhe-DPro-DPhe-LPhe-DPro-LGln)₂
      Purity≥95% by HPLC
      SolubilityDMSO (1 mg/ml) or Acetic Acid (5%)
      Storage -20°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
      Toxicity Standard Handling
      ReferencesPeterson, J.R., et al. 2001. Proc. Natl. Acad. Sci. USA 98, 10624.
      Suetsugu, S., et al. 2001. J. Biol. Chem. 276, 33175.