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616387 Nα-Tosyl-Phe Chloromethyl Ketone

Irreversible inhibitor of chymotrypsin.

Nα-Tosyl-Phe Chloromethyl Ketone: のSDS（安全データシート）、CoA（試験成績書）およびCoQ（品質証明書）、カタログなど製品関連の技術資料を入手いただけます。

同義語: TPCK

Primary Target: chymotrypsin activity in preparations
View This Product on Sigma-Aldrich
616387
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概要

Replacement Information

主要スペック表

CAS #Empirical Formula
402-71-1C₁₇H₁₈ClNO₃S

価格＆在庫状況

カタログ番号 在庫状況包装 Qty/Pk 価格 数量
616387-250MGCN
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      		 樹脂ｱﾝﾌﾟﾙ 250 mg
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      Description
      Overview

      This product has been discontinued.





      Irreversible inhibitor of chymotrypsin. Useful for inhibiting chymotrypsin activity in trypsin preparations. Inhibits apoptosis in thymocytes. Blocks the induction of nitric oxide synthase by γ-interferon and lipopolysaccharides (EC50 = 20 µM).
      Catalogue Number616387
      Brand Family Calbiochem®
      SynonymsTPCK
      References
      ReferencesFearnhead, H.O., et al. 1995. FEBS Lett. 357, 242.
      Griscavage, J.M., et al. 1995. Biochem. Biophys. Res. Commun. 215, 721.
      Weaver, V.M., et al. 1993. Biochem. Cell Biol. 71, 488.
      Murakami, T., et al. 1991. Biochim. Biophys. Acta 1079, 279.
      Nierodzik, M.L., et al. 1991. J. Clin. Invest. 87, 229.
      Wilson, W.E., et al. 1989. J. Biol. Chem. 264, 17777.
      Product Information
      CAS number402-71-1
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₁₇H₁₈ClNO₃S
      Chemical formulaC₁₇H₁₈ClNO₃S
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary Targetchymotrypsin activity in preparations
      Primary Target IC<sub>50</sub>EC50 = 20 µM in blocking the induction of nitric oxide synthase by γ-interferon and lipopolysaccharides.
      Purity≥98% by TLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSXT5613500
      Safety Information
      R PhraseR: 41

      Risk of serious damage to eyes.
      S PhraseS: 26-36

      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Wear suitable protective clothing.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Irritant
      Storage +2°C to +8°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 4 months at 4°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      カタログ番号 GTIN
      616387-250MGCN 04055977186314

      Documentation

      Nα-Tosyl-Phe Chloromethyl Ketone (M)SDS

      タイトル

      英語版製品安全データシート（(M)SDS） 

      Nα-Tosyl-Phe Chloromethyl Ketone 試験成績書（CoA）

      タイトルロット番号
      616387

      参考資料

      参考資料の概要
      Fearnhead, H.O., et al. 1995. FEBS Lett. 357, 242.
      Griscavage, J.M., et al. 1995. Biochem. Biophys. Res. Commun. 215, 721.
      Weaver, V.M., et al. 1993. Biochem. Cell Biol. 71, 488.
      Murakami, T., et al. 1991. Biochim. Biophys. Acta 1079, 279.
      Nierodzik, M.L., et al. 1991. J. Clin. Invest. 87, 229.
      Wilson, W.E., et al. 1989. J. Biol. Chem. 264, 17777.

      引用

      Title
    • Ok Hee Ryu, et al. (2005) Proteolysis of MIP-1α isoforms LD78β and LD78α by neutrophil-derived serine proteases. Journal of Biological Chemistry 280, 17415-17421.
      		•
      データシート

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision13-September-2008 RFH
      SynonymsTPCK
      DescriptionIrreversible inhibitor of chymotrypsin. Useful for inhibiting chymotrypsin activity in trypsin preparations. Inhibits apoptosis in thymocytes. Blocks the induction of nitric oxide synthase by γ-interferon and lipopolysaccharide (EC50 = 20 µM). Suggested working concentration is 10-100 µM.
      FormWhite solid
      CAS number402-71-1
      RTECSXT5613500
      Chemical formulaC₁₇H₁₈ClNO₃S
      Structure formulaStructure formula
      Purity≥98% by TLC
      SolubilityEthanol (5 mg/ml) or Methanol (5 mg/ml)
      Storage +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 4 months at 4°C.
      Toxicity Irritant
      ReferencesFearnhead, H.O., et al. 1995. FEBS Lett. 357, 242.
      Griscavage, J.M., et al. 1995. Biochem. Biophys. Res. Commun. 215, 721.
      Weaver, V.M., et al. 1993. Biochem. Cell Biol. 71, 488.
      Murakami, T., et al. 1991. Biochim. Biophys. Acta 1079, 279.
      Nierodzik, M.L., et al. 1991. J. Clin. Invest. 87, 229.
      Wilson, W.E., et al. 1989. J. Biol. Chem. 264, 17777.
      Citation
    • Ok Hee Ryu, et al. (2005) Proteolysis of MIP-1α isoforms LD78β and LD78α by neutrophil-derived serine proteases. Journal of Biological Chemistry 280, 17415-17421.
      		•