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476300 Myriocin, Mycelia sterilia - CAS 35891-70-4 - Calbiochem

A potent immunosuppressant.

Myriocin, Mycelia sterilia - CAS 35891-70-4 - Calbiochem: のSDS（安全データシート）、CoA（試験成績書）およびCoQ（品質証明書）、カタログなど製品関連の技術資料を入手いただけます。

同義語: ISP-1, Thermozymocidin, [2S,3R,4R]-(E)-2-Amino-3,4-dihydroxy-2-[hydroxymethyl]-14-oxo-6-eicosenoic Acid

Primary Target: Serine palmitoyltransferase
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476300
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概要

Replacement Information

主要スペック表

CAS #Empirical Formula
35891-70-4C₂₁H₃₉NO₆

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      Description
      OverviewA potent immunosuppressant. Displays 10- to 100-fold more potent immunosuppressant activity than cyclosporin A. Potently inhibits serine palmitoyltransferase (SPT; Ki = 280 pM) thereby blocking the synthesis of ceramide. Disrupts substratum adhesion of melanoma cells. Inhibits cell proliferation and induces apoptosis in IL-2 dependent murine cytotoxic T lymphocyte cell line CTLL-2.
      Catalogue Number476300
      Brand Family Calbiochem®
      SynonymsISP-1, Thermozymocidin, [2S,3R,4R]-(E)-2-Amino-3,4-dihydroxy-2-[hydroxymethyl]-14-oxo-6-eicosenoic Acid
      References
      ReferencesHanada, K., et al. 2000. Biochem. Pharmacol. 59, 1211.
      Chen, J.K., et al. 1999. Chem. Biol. 6, 221.
      Hidari, K.I.P.J., et al. 1996. J. Biol. Chem. 271, 14636.
      Nakamura, S., et al. 1996. J. Biol. Chem. 271, 1255.
      Mikaye, Y., et al. 1995. Biochem. Biophys. Res. Commun. 211, 396.
      Fujita, T., et al. 1994. J. Antibiot. 47, 208.
      Product Information
      CAS number35891-70-4
      ATP CompetitiveN
      FormWhite to off-white solid
      Hill FormulaC₂₁H₃₉NO₆
      Chemical formulaC₂₁H₃₉NO₆
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetSerine palmitoyltransferase
      Primary Target K<sub>i</sub>280 pM against serine palmitoyltransferase
      Purity≥95% by TLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSJX3890000
      Safety Information
      R PhraseR: 22

      Harmful if swallowed.
      S PhraseS: 36

      Wear suitable protective clothing.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Harmful
      Storage -20°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      カタログ番号 GTIN
      476300-5MGCN 04055977183801

      Documentation

      Myriocin, Mycelia sterilia - CAS 35891-70-4 - Calbiochem (M)SDS

      タイトル

      英語版製品安全データシート（(M)SDS） 

      Myriocin, Mycelia sterilia - CAS 35891-70-4 - Calbiochem 試験成績書（CoA）

      タイトルロット番号
      476300

      参考資料

      参考資料の概要
      Hanada, K., et al. 2000. Biochem. Pharmacol. 59, 1211.
      Chen, J.K., et al. 1999. Chem. Biol. 6, 221.
      Hidari, K.I.P.J., et al. 1996. J. Biol. Chem. 271, 14636.
      Nakamura, S., et al. 1996. J. Biol. Chem. 271, 1255.
      Mikaye, Y., et al. 1995. Biochem. Biophys. Res. Commun. 211, 396.
      Fujita, T., et al. 1994. J. Antibiot. 47, 208.
      データシート

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision20-September-2019 JSW
      SynonymsISP-1, Thermozymocidin, [2S,3R,4R]-(E)-2-Amino-3,4-dihydroxy-2-[hydroxymethyl]-14-oxo-6-eicosenoic Acid
      DescriptionA potent immunosuppressant. Displays 10- to 100-fold more potent immunosuppressant activity than cyclosporin A. Potently inhibits serine palmitoyltransferase (SPT; Ki = 280 pM) thereby blocking the synthesis of ceramide. Disrupts substratum adhesion of melanoma cells. Inhibits cell proliferation and induces apoptosis in IL-2 dependent murine cytotoxic T lymphocyte cell line CTLL-2.
      FormWhite to off-white solid
      CAS number35891-70-4
      RTECSJX3890000
      Chemical formulaC₂₁H₃₉NO₆
      Structure formulaStructure formula
      Purity≥95% by TLC
      SolubilityDMSO (25 mg/ml)
      Storage -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Harmful
      ReferencesHanada, K., et al. 2000. Biochem. Pharmacol. 59, 1211.
      Chen, J.K., et al. 1999. Chem. Biol. 6, 221.
      Hidari, K.I.P.J., et al. 1996. J. Biol. Chem. 271, 14636.
      Nakamura, S., et al. 1996. J. Biol. Chem. 271, 1255.
      Mikaye, Y., et al. 1995. Biochem. Biophys. Res. Commun. 211, 396.
      Fujita, T., et al. 1994. J. Antibiot. 47, 208.