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475984 MyoVin-1 - CAS 1259177-59-7 - Calbiochem

A pyrazolopyrimidine compound that blocks ADP release from the actomyosin complex and acts as a potent, reversible and uncompetitive inhibitor of actin-stimulated ATPase activity of myosin V.

MyoVin-1 - CAS 1259177-59-7 - Calbiochem: のSDS（安全データシート）、CoA（試験成績書）およびCoQ（品質証明書）、カタログなど製品関連の技術資料を入手いただけます。

同義語: Myosin V Inhibitor 1

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475984
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      		 ｶﾞﾗｽﾋﾞﾝ 5 mg
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      Description
      OverviewA pyrazolopyrimidine compound that blocks ADP release from the actomyosin complex and acts as a potent, reversible and uncompetitive inhibitor of actin-stimulated ATPase activity of myosin V (Ki = 6.3 and 5.5 µM by single- and double-headed myosin V). Displays excellent selectivity over myosin II and myosin IV (< 10 % inhibition at 50 µM) and only minimally inhibits the kinase activity of Cdk1/B, CHK1, Plk1, Abl, ERK2, CKII and Aurora-B (< 10 % inhibition at 100 µM).
      Catalogue Number475984
      Brand Family Calbiochem®
      SynonymsMyosin V Inhibitor 1
      References
      ReferencesIslam, K., et al. 2010. Angew. Chem. Int. Ed. 49, 8484.
      Product Information
      CAS number1259177-59-7
      FormPale yellow powder
      Hill FormulaC₂₉H₂₆N₆O₃S
      Chemical formulaC₂₉H₂₆N₆O₃S
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥95% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      カタログ番号 GTIN
      475984-5MGCN 04055977184372

      Documentation

      MyoVin-1 - CAS 1259177-59-7 - Calbiochem (M)SDS

      タイトル

      英語版製品安全データシート（(M)SDS） 

      MyoVin-1 - CAS 1259177-59-7 - Calbiochem 試験成績書（CoA）

      タイトルロット番号
      475984

      参考資料

      参考資料の概要
      Islam, K., et al. 2010. Angew. Chem. Int. Ed. 49, 8484.
      データシート

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision30-November-2012 JSW
      SynonymsMyosin V Inhibitor 1
      DescriptionA pyrazolopyrimidine compound that blocks ADP release from the actomyosin complex and acts as a potent, reversible and uncompetitive inhibitor of actin-stimulated ATPase activity of myosin V (Ki = 6.3 and 5.5 µM by single- and double-headed myosin V). Displays excellent selectivity over myosin II and myosin IV (< 10 % inhibition at 50 µM) and only minimally inhibits the kinase activity of Cdk1/B, CHK1, Plk1, Abl, ERK2, CKII and Aurora-B (< 10 % inhibition at 100 µM).
      FormPale yellow powder
      Intert gas (Yes/No) Packaged under inert gas
      CAS number1259177-59-7
      Chemical formulaC₂₉H₂₆N₆O₃S
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (50 mg/ml)
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesIslam, K., et al. 2010. Angew. Chem. Int. Ed. 49, 8484.