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475879 Monastrol - CAS 254753-54-3 - Calbiochem

A potent, cell-permeable, non-tubulin-interacting mitosis inhibitor.

Monastrol - CAS 254753-54-3 - Calbiochem: のSDS（安全データシート）、CoA（試験成績書）およびCoQ（品質証明書）、カタログなど製品関連の技術資料を入手いただけます。

同義語: 4-(3-Hydroxyphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydro-4H-pyrimidin-5-carboxylic Acid Ethyl Ester, Eg5 Inhibitor I

Primary Target: Mitotic kinesin Eg5
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475879
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概要

Replacement Information

主要スペック表

CAS #Empirical Formula
254753-54-3C₁₄H₁₆N₂O₃S

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475879-1MGCN
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      		 樹脂ｱﾝﾌﾟﾙ 1 mg
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      475879-5MGCN
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          		 樹脂ｱﾝﾌﾟﾙ 5 mg
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          Description
          OverviewA potent, cell-permeable, non-tubulin-interacting mitosis inhibitor. Arrests mammalian cells in mitosis with monopolar spindles. In vitro, it specifically inhibits the motility of the mitotic kinesin Eg5, a motor protein involved in the assembly and maintenance of the mitotic spindle (IC50 = 14 µM).
          Catalogue Number475879
          Brand Family Calbiochem®
          Synonyms4-(3-Hydroxyphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydro-4H-pyrimidin-5-carboxylic Acid Ethyl Ester, Eg5 Inhibitor I
          References
          ReferencesKapoor, T.M., et al. 2000. J. Cell Biol. 150, 975.
          Mayer, T.U., et al. 1999. Science 286, 971.
          Product Information
          CAS number254753-54-3
          ATP CompetitiveN
          FormWhite solid
          Hill FormulaC₁₄H₁₆N₂O₃S
          Chemical formulaC₁₄H₁₆N₂O₃S
          ReversibleN
          Structure formula ImageStructure formula Image
          Quality LevelMQ100
          Applications
          Biological Information
          Primary TargetMitotic kinesin Eg5
          Primary Target IC<sub>50</sub>14 µM against mitotic kinesin Eg5
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications
          Global Trade Item Number
          カタログ番号 GTIN
          475879-1MGCN 04055977203479
          475879-5MGCN 04055977203486

          Documentation

          Monastrol - CAS 254753-54-3 - Calbiochem (M)SDS

          タイトル

          英語版製品安全データシート（(M)SDS） 

          Monastrol - CAS 254753-54-3 - Calbiochem 試験成績書（CoA）

          タイトルロット番号
          475879

          参考資料

          参考資料の概要
          Kapoor, T.M., et al. 2000. J. Cell Biol. 150, 975.
          Mayer, T.U., et al. 1999. Science 286, 971.
          データシート

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision07-April-2008 RFH
          Synonyms4-(3-Hydroxyphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydro-4H-pyrimidin-5-carboxylic Acid Ethyl Ester, Eg5 Inhibitor I
          DescriptionA potent, cell-permeable, nontubulin-interacting mitosis inhibitor. Arrests mammalian cells in mitosis with monopolar spindles. In vitro, it specifically inhibits the motility of the mitotic kinesin Eg5, a motor protein involved in the assembly and maintenance of the mitotic spindle (IC50 = 14 µM).
          FormWhite solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number254753-54-3
          Chemical formulaC₁₄H₁₆N₂O₃S
          Structure formulaStructure formula
          Purity≥95% by HPLC
          SolubilityDMSO (100 mg/ml)
          Storage Protect from light
          -20°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesKapoor, T.M., et al. 2000. J. Cell Biol. 150, 975.
          Mayer, T.U., et al. 1999. Science 286, 971.