Millipore Sigma Vibrant Logo

475838 Mifepristone - CAS 84371-65-3 - Calbiochem

A cell-permeable synthetic steroid that acts as a potent antagonist of progesterone and glucocorticoid receptors.

Mifepristone - CAS 84371-65-3 - Calbiochem: のSDS（安全データシート）、CoA（試験成績書）およびCoQ（品質証明書）、カタログなど製品関連の技術資料を入手いただけます。

同義語: (11β,17β)-11-(4-(Dimethylamino)phenyl)-17-hydroxy-17-(1-propynyl)estra-4,9-dien-3-one, RU-486

Primary Target: Progesterone and glucocorticoid receptors
View This Product on Sigma-Aldrich
475838
価格＆在庫状況を照会

概要

Replacement Information

主要スペック表

CAS #Empirical Formula
84371-65-3C₂₉H₃₅NO₂

価格＆在庫状況

カタログ番号 在庫状況包装 Qty/Pk 価格 数量
475838-50MGCN
在庫状況検索中…
—
現在国内在庫なし 現在国内在庫なし
現在国内在庫有り 
販売中止
在庫僅少
現在国内在庫あり
    Remaining : Will advise
      Remaining : Will advise
      注文対象外
      お問合せください
      Contact Customer Service

      		 樹脂ｱﾝﾌﾟﾙ 50 mg
      価格を検索中…
      価格が見つかりません
      Minimum Quantity needs to be mulitiple of
      Maximum Quantity is
      弊社照会 詳細を表示　
      値引
      ()
       
      —
      弊社照会
      		 —
      Description
      OverviewA cell-permeable synthetic steroid that acts as a potent antagonist of progesterone and glucocorticoid receptors. Inhibits P-glycoprotein (P-gp) function and down-modulates P-gp mediated drug resistance. Displays anti-angiogenic effects and suppresses vascular endothelial growth factor (VEGF) production. Regulates the expression of Fas and FasL in mouse endometrium and TRAIL in prostate cancer cells. As an antioxidant, it offers neuroprotection against controlled cortical impact (CCI) in CA1 pyramidal cells, as well as Aβ-, H2O2-, and glutamate-induced injury to mouse hippocampal HT22 cells.
      Catalogue Number475838
      Brand Family Calbiochem®
      Synonyms(11β,17β)-11-(4-(Dimethylamino)phenyl)-17-hydroxy-17-(1-propynyl)estra-4,9-dien-3-one, RU-486
      References
      ReferencesMcCullers, D.L., et al. 2002. Neuroscience 109, 219.
      Sidell, N., et al. 2002. Ann. N. Y. Acad. Sci. 955, 159.
      Gao, F., et al. 2001. Acta Pharmacol. Sin. 22, 524.
      Hyder, S.M., et al. 2001. Int. J. Cancer 92, 469.
      Lam, F.C., et al. 2001. J. Neurochem. 76, 1121.
      Sridhar, S., et al. 2001. Cancer Res. 61, 7179.
      Behl, C., et al. 1997. Eur. J. Neurosci. 9, 912.
      Greb, R.R., et al. 1997. Hum. Reprod. 12, 1280.
      Gruol, D.J., et al. 1994. Cancer Res. 54, 3088.
      Product Information
      CAS number84371-65-3
      ATP CompetitiveN
      FormYellow solid
      Hill FormulaC₂₉H₃₅NO₂
      Chemical formulaC₂₉H₃₅NO₂
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetProgesterone and glucocorticoid receptors
      Purity≥99% by titration
      Physicochemical Information
      Cell permeableY
      ContaminantsSteroid substances: ≤0.1%
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSKG2955000
      Safety Information
      R PhraseR: 60-61

      May impair fertility.
      May cause harm to the unborn child.
      S PhraseS: 22-36/37/39-45

      Do not breathe dust.
      Wear suitable protective clothing, gloves and eye/face protection.
      In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Carcinogenic / Teratogenic
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      カタログ番号 GTIN
      475838-50MGCN 04055977184976

      Documentation

      Mifepristone - CAS 84371-65-3 - Calbiochem (M)SDS

      タイトル

      英語版製品安全データシート（(M)SDS） 

      Mifepristone - CAS 84371-65-3 - Calbiochem 試験成績書（CoA）

      タイトルロット番号
      475838

      参考資料

      参考資料の概要
      McCullers, D.L., et al. 2002. Neuroscience 109, 219.
      Sidell, N., et al. 2002. Ann. N. Y. Acad. Sci. 955, 159.
      Gao, F., et al. 2001. Acta Pharmacol. Sin. 22, 524.
      Hyder, S.M., et al. 2001. Int. J. Cancer 92, 469.
      Lam, F.C., et al. 2001. J. Neurochem. 76, 1121.
      Sridhar, S., et al. 2001. Cancer Res. 61, 7179.
      Behl, C., et al. 1997. Eur. J. Neurosci. 9, 912.
      Greb, R.R., et al. 1997. Hum. Reprod. 12, 1280.
      Gruol, D.J., et al. 1994. Cancer Res. 54, 3088.

      カタログ

      タイトル
      Alzheimer's Disease Brochure & Technical Guide
      データシート

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision28-April-2009 RFH
      Synonyms(11β,17β)-11-(4-(Dimethylamino)phenyl)-17-hydroxy-17-(1-propynyl)estra-4,9-dien-3-one, RU-486
      DescriptionA cell-permeable, synthetic steroid that acts as a potent antagonist of progesterone and glucocorticoid receptors. Reported to inhibit P-glycoprotein (P-gp) function and down-modulate P-gp mediated drug resistance. Also displays anti-angiogenic effects and suppresses vascular endothelial growth factor (VEGF) production. Shown to regulate the expression of Fas and FasL in mouse endometrium and of TRAIL in prostate cancer cells. As an antioxidant, it is reported to offer neuroprotection against controlled cortical impact (CCI) in CA1 pyramidal cells, as well as Aβ-, H2O2-, and glutamate-induced injury to mouse hippocampal HT22 cells.
      FormYellow solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number84371-65-3
      RTECSKG2955000
      Chemical formulaC₂₉H₃₅NO₂
      Structure formulaStructure formula
      Purity≥99% by titration
      ContaminantsSteroid substances: ≤0.1%
      SolubilityEthanol (10 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Carcinogenic / Teratogenic
      Merck USA index14, 6186
      ReferencesMcCullers, D.L., et al. 2002. Neuroscience 109, 219.
      Sidell, N., et al. 2002. Ann. N. Y. Acad. Sci. 955, 159.
      Gao, F., et al. 2001. Acta Pharmacol. Sin. 22, 524.
      Hyder, S.M., et al. 2001. Int. J. Cancer 92, 469.
      Lam, F.C., et al. 2001. J. Neurochem. 76, 1121.
      Sridhar, S., et al. 2001. Cancer Res. 61, 7179.
      Behl, C., et al. 1997. Eur. J. Neurosci. 9, 912.
      Greb, R.R., et al. 1997. Hum. Reprod. 12, 1280.
      Gruol, D.J., et al. 1994. Cancer Res. 54, 3088.