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444251 MMP-2/MMP-9 Inhibitor III - Calbiochem

The MMP-2/MMP-9 Inhibitor III controls the biological activity of MMP-2/MMP-9. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

MMP-2/MMP-9 Inhibitor III - Calbiochem: のSDS（安全データシート）、CoA（試験成績書）およびCoQ（品質証明書）、カタログなど製品関連の技術資料を入手いただけます。
Primary Target: MMP-2, MMP-9
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444251
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概要

Replacement Information

主要スペック表

Empirical Formula
C₅₂H₇₁N₁₃O₁₄S₂

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444251-1MGCN
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      Description
      OverviewA hydrophobic cyclic peptide that acts as a potent inhibitor of MMP-2 and MMP-9 (IC50 = 10 µM). Inhibits the migration of human endothelial cells and tumor cells, and prevents tumor growth and invasion in animal models. Also, phage that display this peptide specifically targets angiogenic blood vessels in vivo.
      Catalogue Number444251
      Brand Family Calbiochem®
      References
      ReferencesMedina, O.P., et al. 2001. Cancer Res. 61, 3978.
      Koivunen, E., et al. 1999. Nat. Biotechnology 17, 768.
      Product Information
      ATP CompetitiveN
      DeclarationSold under license of U.S. Patent 6,624,144.
      FormWhite lyophilized solid
      FormulationSupplied as a trifluoroacetate salt.
      Hill FormulaC₅₂H₇₁N₁₃O₁₄S₂
      Chemical formulaC₅₂H₇₁N₁₃O₁₄S₂
      Hygroscopic Hygroscopic
      ReversibleN
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetMMP-2, MMP-9
      Primary Target IC<sub>50</sub>10 µM against MMP-2 and MMP-9
      Purity≥97% by HPLC
      Physicochemical Information
      Cell permeableN
      Peptide SequenceH-Cys¹-Thr-Thr-His-Trp-Gly-Phe-Thr-Leu-Cys¹⁰-OH (cyclic: 1→ 10)
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 2 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      カタログ番号 GTIN
      444251-1MGCN 04055977186512

      Documentation

      MMP-2/MMP-9 Inhibitor III - Calbiochem (M)SDS

      タイトル

      英語版製品安全データシート（(M)SDS） 

      MMP-2/MMP-9 Inhibitor III - Calbiochem 試験成績書（CoA）

      タイトルロット番号
      444251

      参考資料

      参考資料の概要
      Medina, O.P., et al. 2001. Cancer Res. 61, 3978.
      Koivunen, E., et al. 1999. Nat. Biotechnology 17, 768.
      データシート

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision06-August-2008 RFH
      DescriptionA cyclic peptide that acts as a potent inhibitor of MMP-2 (gelatinase A; IC50 = 10 µM) and MMP-9 (gelatinase B; IC50 = 10 µM). Inhibits the migration of human endothelial cells and tumor cells, and prevents tumor growth and invasion in animal models.
      FormWhite lyophilized solid
      FormulationSupplied as a trifluoroacetate salt.
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₅₂H₇₁N₁₃O₁₄S₂
      Peptide SequenceH-Cys¹-Thr-Thr-His-Trp-Gly-Phe-Thr-Leu-Cys¹⁰-OH (cyclic: 1→ 10)
      Purity≥97% by HPLC
      SolubilityH₂O (5 mg/ml)
      Storage -20°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 2 months at -20°C.
      Toxicity Standard Handling
      ReferencesMedina, O.P., et al. 2001. Cancer Res. 61, 3978.
      Koivunen, E., et al. 1999. Nat. Biotechnology 17, 768.