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444249 MMP-2/MMP-9 Inhibitor II - CAS 193807-60-2 - Calbiochem

The MMP-2/MMP-9 Inhibitor II, also referenced under CAS 193807-60-2, controls the biological activity of MMP-2/MMP-9. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

MMP-2/MMP-9 Inhibitor II - CAS 193807-60-2 - Calbiochem: のSDS（安全データシート）、CoA（試験成績書）およびCoQ（品質証明書）、カタログなど製品関連の技術資料を入手いただけます。

同義語: (2R)-[(4-Biphenylylsulfonyl)amino]-N-hydroxy-3-phenylpropionamide, BiPS, BiPS

Primary Target: MMP-2
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444249
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概要

Replacement Information

主要スペック表

CAS #Empirical Formula
193807-60-2C₂₁H₂₀N₂O₄S

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      Description
      OverviewA potent inhibitor of MMP-2 (IC50 = 17 nM) and MMP-9 (IC50 = 30 nM). Also shown to potently induce and rapidly activate HIF. Reported to inhibit Lewis lung carcinoma-induced lung colonization in a murine model.
      Catalogue Number444249
      Brand Family Calbiochem®
      Synonyms(2R)-[(4-Biphenylylsulfonyl)amino]-N-hydroxy-3-phenylpropionamide, BiPS, BiPS
      References
      ReferencesLauzier, M.C., et al. 2008. Mol. Pharmacol. In press.
      Mifune, M., et al. 2005. J. Biol. Chem. 280, 26592.
      Zhang, H., et al. 2004. Circ. Res. 95, 989.
      Tamura, Y., et al. 1998. J. Med. Chem. 41, 640.
      Product Information
      CAS number193807-60-2
      ATP CompetitiveN
      FormOff-white solid
      Hill FormulaC₂₁H₂₀N₂O₄S
      Chemical formulaC₂₁H₂₀N₂O₄S
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetMMP-2
      Primary Target IC<sub>50</sub>17 nM, 30 nM against MMP-2, and MMP-9, respectively
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      カタログ番号 GTIN
      444249-1MGCN 04055977186499

      Documentation

      MMP-2/MMP-9 Inhibitor II - CAS 193807-60-2 - Calbiochem (M)SDS

      タイトル

      英語版製品安全データシート（(M)SDS） 

      MMP-2/MMP-9 Inhibitor II - CAS 193807-60-2 - Calbiochem 試験成績書（CoA）

      タイトルロット番号
      444249

      参考資料

      参考資料の概要
      Lauzier, M.C., et al. 2008. Mol. Pharmacol. In press.
      Mifune, M., et al. 2005. J. Biol. Chem. 280, 26592.
      Zhang, H., et al. 2004. Circ. Res. 95, 989.
      Tamura, Y., et al. 1998. J. Med. Chem. 41, 640.
      データシート

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision01-April-2011 RFH
      Synonyms(2R)-[(4-Biphenylylsulfonyl)amino]-N-hydroxy-3-phenylpropionamide, BiPS, BiPS
      DescriptionA potent inhibitor of type IV collagenases, MMP-2 (IC50 = 17 nM) and MMP-9 (IC50 = 30 nM). Also shown to potently induce and rapidly activate HIF. Has been shown in vivo to inhibit Lewis lung carcinoma-induced lung colonization in a murine model.
      FormOff-white solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number193807-60-2
      Chemical formulaC₂₁H₂₀N₂O₄S
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (100 mg/ml) or Methanol (25 mg/ml)
      Storage -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesLauzier, M.C., et al. 2008. Mol. Pharmacol. In press.
      Mifune, M., et al. 2005. J. Biol. Chem. 280, 26592.
      Zhang, H., et al. 2004. Circ. Res. 95, 989.
      Tamura, Y., et al. 1998. J. Med. Chem. 41, 640.