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Merck

HNDG4MAG-36K

MILLIPLEX® Human Neurodegenerative Disease Panel

Configurable Human Neurodegenerative Disease 5-Plex Panel 4

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この商品について

UNSPSC Code:
12161503
NACRES:
NA.84
eCl@ss:
32161000


製品名

MILLIPLEX® Human Neurodegenerative Disease Panel,

Quality Segment

description

Configurable Human Neurodegenerative Disease 5-Plex Panel 4

species reactivity

human

packaging

pkg of 1 ea

manufacturer/tradename

Milliplex®

assay range

accuracy: 84-108%, standard curve range: 14-10,000 pg/mL
(S100B), standard curve range: 21-15,000 pg/mL
(sRAGE), standard curve range: 27-20,000 pg/mL
(Amyloid β42), standard curve range: 3-2,500 pg/mL
(Amyloid β40), standard curve range: 7-5,000 pg/mL
(GDNF)

technique(s)

multiplexing: suitable

input

cerebrospinal fluid(s) (CSF)

detection method

fluorometric (Luminex® xMAP® technology)

shipped in

wet ice

storage temp.

2-8°C

General description

Alzheimer′s pathology is shaped by a dynamic interplay between toxic aggregates and protective responses. Amyloid-beta peptides 40 and 42 form the core of senile plaques. S100B, a calcium-binding protein, interacts with these aggregates and activates RAGE signaling, amplifying neuroinflammation. sRAGE, in contrast, acts as a decoy receptor, potentially limiting amyloid transport across the blood-brain barrier. GDNF supports neuronal survival, offering a counterbalance to degenerative forces.

Application

MILLIPLEX® Qualified assays undergo rigorous assay development, verification, and Quality Control testing to achieve optimal performance. Simultaneously analyze up to 5 analytes in human cerebrospinal fluid (CSF).

Analytes included: S100B, Amyloid β40 (Aβ40), Amyloid β42 (Aβ42), sRAGE, GDNF.

Note: Serum and plasma are not verified sample types for this assay.

Assay Characteristics: Refer to kit protocol for assay cross-reactivity, sensitivity, precision, and accuracy.

Features and Benefits

  • Comprehensive Alzheimer′s Pathway Coverage: Simultaneously quantify amyloid-beta peptides, S100B neuroinflammation marker, sRAGE receptor, and GDNF neuroprotective factor, providing complete insight into key Alzheimer′s disease mechanisms in one assay.

  • CSF-Optimized Excellence: Specifically verified for cerebrospinal fluid analysis with exceptional spike recovery (84-108%), ensuring accurate quantification of these critical brain-derived biomarkers in precious CSF samples.

  • Streamlined Neuroscience Discovery: Eliminate the complexity of five separate assays with our integrated multiplex format, accelerating your Alzheimer′s research while maximizing the utility of limited CSF samples for comprehensive biomarker profiling.

  • Target Discovery Power: Leverage biomarkers spanning amyloid aggregation, neuroinflammation, and neuroprotection pathways to identify therapeutic interventions targets.

  • Precision-Engineered Reliability: Trust in < 10% intra-assay precision across all analytes and < 15% inter-assay variability, delivering the data consistency essential for breakthrough neurodegenerative research.

Legal Information

Luminex is a registered trademark of Luminex Corp
MILLIPLEX is a registered trademark of Merck KGaA, Darmstadt, Germany
xMAP is a registered trademark of Luminex Corp

Disclaimer

For research use only. Not for use in diagnostic procedures.

Label License/Sticker for Assay Product:

By opening the packaging containing this Assay Product (which contains fluorescently labeled microsphere beads authorized by Luminex Corporation) or using this Assay Product in any manner, you are consenting and agreeing to be bound by the End User Terms and Conditions and the End User License Agreement available at http://support.diasorin.com/end-user-terms-and-conditions/. If you do not agree to all of the terms and conditions, you must promptly return this Assay Product for a full refund prior to using it in any manner.


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Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 2 - Skin Sens. 1

保管分類

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3


適用法令

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