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474780 MG-115 - CAS 133407-86-0 - Calbiochem

Potent reversible proteasome inhibitor (Ki = 21 nM and 35 nM for 20S and 26S proteasome, respectively).

MG-115 - CAS 133407-86-0 - Calbiochem: のSDS（安全データシート）、CoA（試験成績書）およびCoQ（品質証明書）、カタログなど製品関連の技術資料を入手いただけます。

同義語: Carbobenzoxy-L-leucyl-L-leucyl-L-norvalinal, Z-LL-Nva-CHO, Proteasome Inhibitor XII

Primary Target: 20S proteasome
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474780
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概要

Replacement Information

主要スペック表

CAS #Empirical Formula
133407-86-0C₂₅H₃₉N₃O₅

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      Description
      OverviewPotent reversible proteasome inhibitor (Ki = 21 nM and 35 nM for 20S and 26S proteasome, respectively). Specifically inhibits the chymotrypsin-like activity of the proteasome and induces apoptosis in Rat-1 and PC12 cells.
      Catalogue Number474780
      Brand Family Calbiochem®
      SynonymsCarbobenzoxy-L-leucyl-L-leucyl-L-norvalinal, Z-LL-Nva-CHO, Proteasome Inhibitor XII
      References
      ReferencesLopes, U.G., et al. 1997. J. Biol. Chem. 272, 12893.
      Lee, D.H., and Goldberg, A.L. 1996. J. Biol. Chem. 271, 27280.
      Palombella, V.J., et al. 1994. Cell 78, 773. Rock, K.L., et al. 1994. Cell 78, 761.
      Vinitsky, A., et al. 1992. Biochemistry 31, 9421.
      Product Information
      CAS number133407-86-0
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₂₅H₃₉N₃O₅
      Chemical formulaC₂₅H₃₉N₃O₅
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary Target20S proteasome
      Primary Target K<sub>i</sub>21 nM and 35 nM for 20S and 26S proteasome, respectively
      Purity≥90% by HPLC
      Physicochemical Information
      Cell permeableN
      Peptide SequenceZ-Leu-Leu-Nva-CHO
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      カタログ番号 GTIN
      474780-5MGCN 04055977185447

      Documentation

      MG-115 - CAS 133407-86-0 - Calbiochem (M)SDS

      タイトル

      英語版製品安全データシート（(M)SDS） 

      MG-115 - CAS 133407-86-0 - Calbiochem 試験成績書（CoA）

      タイトルロット番号
      474780

      参考資料

      参考資料の概要
      Lopes, U.G., et al. 1997. J. Biol. Chem. 272, 12893.
      Lee, D.H., and Goldberg, A.L. 1996. J. Biol. Chem. 271, 27280.
      Palombella, V.J., et al. 1994. Cell 78, 773. Rock, K.L., et al. 1994. Cell 78, 761.
      Vinitsky, A., et al. 1992. Biochemistry 31, 9421.

      カタログ

      タイトル
      Caspases and other Apoptosis Related Tools Brochure
      Proteasomes Technical Bulletin
      データシート

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision01-April-2011 RFH
      SynonymsCarbobenzoxy-L-leucyl-L-leucyl-L-norvalinal, Z-LL-Nva-CHO, Proteasome Inhibitor XII
      DescriptionPotent reversible proteasome inhibitor (Ki = 21 nM and 35 nM for 20S and 26S proteasome, respectively).
      FormWhite solid
      CAS number133407-86-0
      Chemical formulaC₂₅H₃₉N₃O₅
      Peptide SequenceZ-Leu-Leu-Nva-CHO
      Structure formulaStructure formula
      Purity≥90% by HPLC
      SolubilityDMSO (50 mg/ml)
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesLopes, U.G., et al. 1997. J. Biol. Chem. 272, 12893.
      Lee, D.H., and Goldberg, A.L. 1996. J. Biol. Chem. 271, 27280.
      Palombella, V.J., et al. 1994. Cell 78, 773. Rock, K.L., et al. 1994. Cell 78, 761.
      Vinitsky, A., et al. 1992. Biochemistry 31, 9421.