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444966 MEK1/2 Inhibitor III - CAS 391210-10-9 - Calbiochem

MEK1/2 Inhibitor III, CAS 391210-10-9, is a cell-permeable, non-competitive, highly potent MEK/MAPKK/MKK inhibitor that blocks cellular Erk1/2 phosphorylation (IC50 = 25 in serum starved HeLa cells).

MEK1/2 Inhibitor III - CAS 391210-10-9 - Calbiochem: のSDS（安全データシート）、CoA（試験成績書）およびCoQ（品質証明書）、カタログなど製品関連の技術資料を入手いただけます。

同義語: PD325901, PD0325901, N-((2R)-2,3-Dihyroxypropoxy)-3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)-benzamide, PD 0325901, MEK Inhibitor III

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444966
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概要

Replacement Information

主要スペック表

CAS #Empirical Formula
391210-10-9C₁₆H₁₄F₃IN₂O₄

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      Description
      OverviewA cell-permeable benzamide compound that acts as a non-competitive, highly potent, selective MEK/MAPKK/MKK inhibitor and effectively blocks cellular Erk1/2 phosphorylation (by >90% in serum-starved HeLa after serum-stimulation and 50% in C26 with 25 and 0.33 nM inhibitor, respectively), while exhibiting little or no effect against the activity of Erk1/2 or a panel of 66 other kinases even at concentrations as high as 10 µM in cell-free kinase assays. Shown to be orally available in mice and suppress both the growth of and Erk phosphorylation in BRAF(V600E)-expressing SKMEL28 cell-derived tumor in vivo. Also available in InSolution™ format (Cat. No. 444968).
      Catalogue Number444966
      Brand Family Calbiochem®
      SynonymsPD325901, PD0325901, N-((2R)-2,3-Dihyroxypropoxy)-3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)-benzamide, PD 0325901, MEK Inhibitor III
      References
      ReferencesBarrett, S.D., et al. 2008. Bioorg. Med. Chem. Lett. 18, 6501.
      Leyton, J., et al. 2008. Mol. Cancer Ther. 7, 3112.
      Silva, J., et al. 2008. PLoS Biol. 6, 2237.
      Ying, Q.L., et al. 2008. Nature 453, 519.
      Bain, J., et al. 2007. Biochem. J. 408, 297.
      Solit, D.B., et al. 2006. Nature 439, 358.
      Product Information
      CAS number391210-10-9
      FormWhite to off-white solid
      Hill FormulaC₁₆H₁₄F₃IN₂O₄
      Chemical formulaC₁₆H₁₄F₃IN₂O₄
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      ApplicationMEK1/2 Inhibitor III, CAS 391210-10-9, is a cell-permeable, non-competitive, highly potent MEK/MAPKK/MKK inhibitor that blocks cellular Erk1/2 phosphorylation (IC50 = 25 in serum starved HeLa cells).
      Biological Information
      Purity≥95% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      カタログ番号 GTIN
      444966-5MGCN 04055977204520

      Documentation

      MEK1/2 Inhibitor III - CAS 391210-10-9 - Calbiochem (M)SDS

      タイトル

      英語版製品安全データシート（(M)SDS） 

      MEK1/2 Inhibitor III - CAS 391210-10-9 - Calbiochem 試験成績書（CoA）

      タイトルロット番号
      444966

      参考資料

      参考資料の概要
      Barrett, S.D., et al. 2008. Bioorg. Med. Chem. Lett. 18, 6501.
      Leyton, J., et al. 2008. Mol. Cancer Ther. 7, 3112.
      Silva, J., et al. 2008. PLoS Biol. 6, 2237.
      Ying, Q.L., et al. 2008. Nature 453, 519.
      Bain, J., et al. 2007. Biochem. J. 408, 297.
      Solit, D.B., et al. 2006. Nature 439, 358.

      カタログ

      タイトル
      メルクミリポアが自信をもってお届けする ES/iPS 細胞関連製品＆がん幹細胞関連新製品

      データシート

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      Reprogramming Cell Fate and Function Novel Strategies for iPSC Generation, Characterization, and Differentiation
      データシート

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision07-May-2018 JSW
      SynonymsPD325901, PD0325901, N-((2R)-2,3-Dihyroxypropoxy)-3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)-benzamide, PD 0325901, MEK Inhibitor III
      DescriptionA cell-permeable benzamide compound that acts as a non-competitive, highly potent, selective MEK/MAPKK/MKK inhibitor and effectively blocks cellular Erk1/2 phosphorylation (by >90% in serum-starved HeLa after serum-stimulation and 50% in C26 with 25 and 0.33 nM inhibitor, respectively), while exhibiting little or no effect against the activity of Erk1/2 or a panel of 66 other kinases even at concentrations as high as 10 µM in cell-free kinase assays. Shown to be orally available in mice and suppress both the growth of and Erk phosphorylation in BRAF(V600E)-expressing SKMEL28 cell-derived tumor in vivo.
      FormWhite to off-white solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number391210-10-9
      Chemical formulaC₁₆H₁₄F₃IN₂O₄
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (20 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesBarrett, S.D., et al. 2008. Bioorg. Med. Chem. Lett. 18, 6501.
      Leyton, J., et al. 2008. Mol. Cancer Ther. 7, 3112.
      Silva, J., et al. 2008. PLoS Biol. 6, 2237.
      Ying, Q.L., et al. 2008. Nature 453, 519.
      Bain, J., et al. 2007. Biochem. J. 408, 297.
      Solit, D.B., et al. 2006. Nature 439, 358.