数量	カタログ番号	注文内容	Qty/Pk	価格
			96-Well Plate

数量	カタログ番号	注文内容	Qty/Pk	価格
	48-602MAG	Buffer Detection Kit for Magnetic Beads	1 Kit

438186 Sigma-AldrichLovastatin, Sodium Salt - Calbiochem

Carboxylate form of Lovastatin that is active in whole cells and cell-free assays.

Lovastatin, Sodium Salt - Calbiochem: のSDS（安全データシート）、CoA（試験成績書）およびCoQ（品質証明書）、カタログなど製品関連の技術資料を入手いただけます。

(M)SDS
試験成績書（CoA）
参考資料
Data Sheet

同義語: L-Type Calcium Channel Blocker IV

Primary Target: 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase

View This Product on Sigma-Aldrich

お勧めの製品

概要

Replacement Information

主要スペック表

Empirical Formula
C₂₄H₃₇O₆ • Na

価格＆在庫状況

カタログ番号	在庫状況	包装	Qty/Pk	価格	数量
438186-5MGCN	在庫状況検索中… — 現在国内在庫なし現在国内在庫有り販売中止在庫僅少現在国内在庫あり在庫を照会するにはログインしてください現在国内在庫有り現在国内在庫なし現在国内在庫有り Remaining : Will advise Remaining : Will advise 注文対象外お問合せください Contact Customer Service お問合せくださいお問合せください	樹脂ｱﾝﾌﾟﾙ	5 mg	価格を検索中… 価格が見つかりません Minimum Quantity needs to be mulitiple of Maximum Quantity is 弊社照会詳細を表示　値引 () — 弊社照会納入価格を閲覧するにはログインしてください	在庫状況を照会 —	お気に入り/ショッピングリストに追加お気に入り/ショッピングリストに追加お気に入りに追加されました

Description
Overview	Carboxylate form of Lovastatin (Cat. No. 438185) that is active in whole cells and cell-free assays.
Catalogue Number	438186
Brand Family	Calbiochem®
Synonyms	L-Type Calcium Channel Blocker IV

References
References	Rao, S., et al. 1999. Proc. Natl. Acad. Sci. USA 96, 7197. Carel, K., et al. 1996. J. Biol. Chem. 271, 30625. McGuire, T.F., et al. 1996. J. Biol. Chem. 271, 27402. Umetani, N., et al. 1996. Biochim. Biophys. Acta 1303, 199. Xu, X.Q., et al. 1996. Arch. Biochem. Biophys. 326, 233. Reusch, J.E.-B., et al. 1995. J. Biol. Chem. 270, 2036.

Product Information
ATP Competitive	N
Form	Off-white solid
Hill Formula	C₂₄H₃₇O₆ • Na
Chemical formula	C₂₄H₃₇O₆ • Na
Hygroscopic	Hygroscopic
Reversible	N
Structure formula Image
Quality Level	MQ200

Applications

Biological Information
Primary Target	3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase
Purity	≥95% by HPLC

Physicochemical Information
Cell permeable	Y

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Carcinogenic / Teratogenic
Storage	-20°C
Hygroscopic	Hygroscopic
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot, flush with an inert gas, and freeze (-20°C). Stock solutions in high quality ethanol are stable for up to 1 month at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
カタログ番号	GTIN
438186-5MGCN	07790788050276

Documentation

Lovastatin, Sodium Salt - Calbiochem (M)SDS

タイトル
英語版製品安全データシート（(M)SDS）

Lovastatin, Sodium Salt - Calbiochem 試験成績書（CoA）

タイトル	ロット番号
438186	ロット番号を入力

参考資料

参考資料の概要
Rao, S., et al. 1999. Proc. Natl. Acad. Sci. USA 96, 7197. Carel, K., et al. 1996. J. Biol. Chem. 271, 30625. McGuire, T.F., et al. 1996. J. Biol. Chem. 271, 27402. Umetani, N., et al. 1996. Biochim. Biophys. Acta 1303, 199. Xu, X.Q., et al. 1996. Arch. Biochem. Biophys. 326, 233. Reusch, J.E.-B., et al. 1995. J. Biol. Chem. 270, 2036.

データシート

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	06-August-2008 RFH
Synonyms	L-Type Calcium Channel Blocker IV
Description	Carboxylate form of Lovastatin (Cat. No. 438185) that is active in whole cells and cell-free assays. Lovastatin is reported to be an anti-hypercholesterolemic agent that acts as an inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase and blocks a series of biological events including activation of p21^ras by insulin in 3T3-L1 fibroblasts and 3T3-L1 adipocytes, farnesylation of p21^ras, which decreases the pool of intracellular Ras available for subsequent activation by growth factors (including insulin), and N-ras-induced neuronal differentiation. Causes cell cycle arrest in the late G₁ phase. Shown to inhibit the stimulation of MAP kinase by insulin in HIRcB cells and block the transcription of the type-I SCR gene in THP-1-derived macrophages. Also blocks PDGF receptor tyrosine phosphorylation and MAP kinase activation by PDGF.
Form	Off-white solid
Intert gas (Yes/No)	Packaged under inert gas
Chemical formula	C₂₄H₃₇O₆ • Na
Structure formula
Purity	≥95% by HPLC
Solubility	DMSO (100 mg/ml) or Ethanol (50 mg/ml)
Storage	-20°C Hygroscopic
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot, flush with an inert gas, and freeze (-20°C). Stock solutions in high quality ethanol are stable for up to 1 month at -20°C.
Toxicity	Carcinogenic / Teratogenic
References	Rao, S., et al. 1999. Proc. Natl. Acad. Sci. USA 96, 7197. Carel, K., et al. 1996. J. Biol. Chem. 271, 30625. McGuire, T.F., et al. 1996. J. Biol. Chem. 271, 27402. Umetani, N., et al. 1996. Biochim. Biophys. Acta 1303, 199. Xu, X.Q., et al. 1996. Arch. Biochem. Biophys. 326, 233. Reusch, J.E.-B., et al. 1995. J. Biol. Chem. 270, 2036.

カテゴリー

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Lipid Signaling Inhibitors > HMG-CoA (3-Hydroxy-3-Methylglutaryl Coenzyme A) Reductase Inhibitors

製品がカートに追加されました