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1.09333

LiChrosorb® RP-18 (5 µm) HPLC Columns

HPLC sorbent

別名:

TM=["LiChrosorb"] C18 sorbent for HPLC

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この商品について

UNSPSC Code:
41115709
NACRES:
SB.52
Particle size:
10 μm
Matrix active group:
C18 (RP18), C18 bonding phase
Pore size:
100 Å pore size
Matrix:
fully porous particle
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製品名

LiChrosorb® RP-18 (5 µm),

material

stainless steel column

agency

suitable for USP L1

product line

LiChrosorb®

feature

endcapped: no

parameter

60 °C max. temp.

technique(s)

HPLC: suitable, mass spectrometry (MS): suitable (Low)

matrix

fully porous particle

matrix active group

C18 (RP18), C18 bonding phase

particle size

10 μm

pore size

100 Å pore size

operating pH range

2-7.5

bulk density

200‑400 kg/m3

separation technique

reversed phase

storage temp.

no temp limit

General description

LiChrosorb® RP-18 is a reliable irregular shaped silica gel carriers with reversed phase properties. It is well suited for the separation of neutral, acidic and weak basic compounds.

Application


  • Determination of berberine in human serum by reversed-phase high performance liquid chromatography.: This study outlines a method for detecting berberine in human serum using reversed-phase HPLC, utilizing the LiChrosorb RP-18 column for its reliability in separating chemical compounds in biological samples (Sun Y et al., 1997).

  • Kinetics of hydrolysis of 4-methoxy-2-[2-hydroxy-3(4-phenyl-1-piperazinyl)]propyl-2,3-dihydro-6-methyl-1,3-dioxo-1H-pyrrolo[3,4-c]pyridine in aqueous solutions.: This research employs RP-18 to study the stability and hydrolysis kinetics of a complex organic compound, highlighting its application in pharmaceutical analysis (Muszalska I et al., 2004).

  • A validated spectrophotometric and liquid chromatography method for determination and purity evaluation of 4-methoxy-2-[2-hydroxy-3(4-phenyl-1-piperazinyl)]propyl-2,3-dihydro-6-methyl-1,3-dioxo-1H-pyrrolo[3,4-c]pyridine.: This paper details the use of RP-18 in validating a method for assessing the purity of pharmaceutical compounds, demonstrating its essential role in quality control (Muszalska I et al., 2003).

  • High-performance liquid chromatographic determination of the antifungal drug fluconazole in plasma and saliva of human immunodeficiency virus-infected patients.: This study utilizes RP-18 to monitor fluconazole in clinical samples, providing insights into the pharmacokinetics and therapeutic monitoring of antifungal treatment in HIV patients (Beijnen JH et al., 1995).

  • Ion-pair solid-phase extraction of cimetidine from plasma and subsequent analysis by high-performance liquid chromatography.: Describes a method using RP-18 for the extraction and analysis of cimetidine, a drug used to treat heartburn and peptic ulcers, from plasma samples, illustrating its versatility in drug analysis (Russel FG et al., 1994).


Analysis Note

Theoretical Plates (N/m) (Toluene): ≥ 60000
stability testing (performance): passes test
separation factor (Acetophenone/Phenol, selectivity test): 1.8 - 2.2
separation factor (Acetophenone/Cinnamic acid, selectivity test): 1.1 - 1.4
separation factor (1-Naphtol/Phenol, selectivity test): 3.9 - 4.7
capacity factor (Toluene): 16.0 - 21.0
Particle Size (d10): 3.8 - 4.3 µm
Particle Size (d50): 6.7 - 7.7 µm
Particle Size (d90): 12.0 - 14.0 µm

Legal Information

LiChrosorb is a registered trademark of Merck KGaA, Darmstadt, Germany

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保管分類

11 - Combustible Solids

wgk

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable

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グローバルトレードアイテム番号

カタログ番号GTIN
1.09333.001004022536113562