数量	カタログ番号	注文内容	Qty/Pk	価格
			96-Well Plate

数量	カタログ番号	注文内容	Qty/Pk	価格
	48-602MAG	Buffer Detection Kit for Magnetic Beads	1 Kit

435300 Sigma-AldrichLFM-A13 - CAS 62004-35-7 - Calbiochem

A potent, cell-permeable, reversible, substrate competitive, and specific inhibitor of Bruton's Tyrosine Kinase (BTK; IC₅₀ = 17.2 µM for human BTK in vitro and IC₅₀ = 2.5 µM for recombinant BTK).

LFM-A13 - CAS 62004-35-7 - Calbiochem: のSDS（安全データシート）、CoA（試験成績書）およびCoQ（品質証明書）、カタログなど製品関連の技術資料を入手いただけます。

(M)SDS
試験成績書（CoA）
参考資料
Data Sheet
Citations

同義語: α-Cyano-β-hydroxy-β-methyl-N-(2,5-dibromophenyl)propenamide, BTK Inhibitor I, Bruton's Tyrosine Kinase Inhibitor I

Primary Target: Human Bruton's Tyrosine Kinase (BTK)

View This Product on Sigma-Aldrich

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概要

Replacement Information

主要スペック表

CAS #	Empirical Formula
62004-35-7	C₁₁H₈Br₂N₂O₂

価格＆在庫状況

カタログ番号	在庫状況	包装	Qty/Pk	価格	数量
435300-5MGCN	在庫状況検索中… — 現在国内在庫なし現在国内在庫有り販売中止在庫僅少現在国内在庫あり在庫を照会するにはログインしてください現在国内在庫有り現在国内在庫なし現在国内在庫有り Remaining : Will advise Remaining : Will advise 注文対象外お問合せください Contact Customer Service お問合せくださいお問合せください	樹脂ｱﾝﾌﾟﾙ	5 mg	価格を検索中… 価格が見つかりません Minimum Quantity needs to be mulitiple of Maximum Quantity is 弊社照会詳細を表示　値引 () — 弊社照会納入価格を閲覧するにはログインしてください	在庫状況を照会 —	お気に入り/ショッピングリストに追加お気に入り/ショッピングリストに追加お気に入りに追加されました

Description
Overview	A potent, cell-permeable, reversible, substrate competitive, and specific inhibitor of Bruton’s Tyrosine Kinase (BTK; IC₅₀ = 17.2 µM for human BTK in vitro and IC₅₀ = 2.5 µM for recombinant BTK). Also inhibits Polo-like kinase in an ATP-competitive manner (IC₅₀ = 10 µM and 61 µM for Plx1 and Plk3, respectively), and displays antitumor properties. Does not affect the enzymatic activity of other protein tyrosine kinases, including EGFR, HCK, IRK JAK1, and JAK3 even at concentrations of 278 µM. Enhances the chemosensitivity of BTK-positive B-lineage leukemia cells to ceramide- and vincristine-induced apoptosis.
Catalogue Number	435300
Brand Family	Calbiochem®
Synonyms	α-Cyano-β-hydroxy-β-methyl-N-(2,5-dibromophenyl)propenamide, BTK Inhibitor I, Bruton's Tyrosine Kinase Inhibitor I

References
References	Uckun, F.M., et al. 2006. Bioorg. Med. Chem. In press. Mahajan, S., et al. 1999. J. Biol. Chem. 274, 9587. Vassilev, A., et al. 1999. J. Biol. Chem. 274, 1646.

Product Information
CAS number	62004-35-7
ATP Competitive	Y
Form	Light brown solid
Hill Formula	C₁₁H₈Br₂N₂O₂
Chemical formula	C₁₁H₈Br₂N₂O₂
Reversible	Y
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Primary Target	Human Bruton's Tyrosine Kinase (BTK)
Primary Target IC<sub>50</sub>	17.2 µM for human BTK in vitro and 2.5 µM for recombinant BTK
Purity	≥97% by HPLC

Physicochemical Information
Cell permeable	Y

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Standard Handling
Storage	+2°C to +8°C
Protect from Light	Protect from light
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
カタログ番号	GTIN
435300-5MGCN	04055977210293

Documentation

LFM-A13 - CAS 62004-35-7 - Calbiochem (M)SDS

タイトル
英語版製品安全データシート（(M)SDS）

LFM-A13 - CAS 62004-35-7 - Calbiochem 試験成績書（CoA）

タイトル	ロット番号
435300	ロット番号を入力

参考資料

参考資料の概要
Uckun, F.M., et al. 2006. Bioorg. Med. Chem. In press. Mahajan, S., et al. 1999. J. Biol. Chem. 274, 9587. Vassilev, A., et al. 1999. J. Biol. Chem. 274, 1646.

引用

Title

Sarah L Doyle, Caroline A Jefferies and Luke A O'Neill. (2005) Bruton's tyrosine kinase is involved in p65-mediated transactivation and phosphorylation of p65 on serine 536 during NF-B activation by LPS. Journal of Biological Chemistry 280, 23496-23501.

データシート

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	12-January-2010 RFH
Synonyms	α-Cyano-β-hydroxy-β-methyl-N-(2,5-dibromophenyl)propenamide, BTK Inhibitor I, Bruton's Tyrosine Kinase Inhibitor I
Description	A potent, cell-permeable, reversible, substrate competitive, and specific inhibitor of Bruton's tyrosine kinase (BTK; IC₅₀ = 17.2 µM for human BTK in vitro and IC₅₀ = 2.5 µM for recombinant BTK). Also inhibits Polo-like kinase in an ATP-competitive manner (IC₅₀ = 10 µM and 61 µM for Plx1 and Plk3, respectively), and displays antitumor properties. Does not affect the enzymatic activity of other protein tyrosine kinases, including EGFR, HCK, IRK JAK1, and JAK3 even at concentrations of 278 µM. Enhances the chemosensitivity of BTK-positive B-lineage leukemia cells to ceramide- and vincristine-induced apoptosis.
Form	Light brown solid
Intert gas (Yes/No)	Packaged under inert gas
CAS number	62004-35-7
Chemical formula	C₁₁H₈Br₂N₂O₂
Structure formula
Purity	≥97% by HPLC
Solubility	DMSO (200 mg/ml)
Storage	Protect from light +2°C to +8°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity	Standard Handling
References	Uckun, F.M., et al. 2006. Bioorg. Med. Chem. In press. Mahajan, S., et al. 1999. J. Biol. Chem. 274, 9587. Vassilev, A., et al. 1999. J. Biol. Chem. 274, 1646.
Citation	Sarah L Doyle, Caroline A Jefferies and Luke A O'Neill. (2005) Bruton's tyrosine kinase is involved in p65-mediated transactivation and phosphorylation of p65 on serine 536 during NF-B activation by LPS. Journal of Biological Chemistry 280, 23496-23501.

カテゴリー

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > Protein Tyrosine Kinase (PTK) Inhibitors

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