数量	カタログ番号	注文内容	Qty/Pk	価格
			96-Well Plate

数量	カタログ番号	注文内容	Qty/Pk	価格
	48-602MAG	Buffer Detection Kit for Magnetic Beads	1 Kit

422175 Sigma-AldrichL-165,041 - CAS 79558-09-1 - Calbiochem

A cell-permeable phenoxyacetic acid derivative that acts as a potent and selective peroxisome proliferator activator receptor δ (PPARδ) agonist (K_i = 6 nM for hPPARδ and 730 nM for hPPARγ).

L-165,041 - CAS 79558-09-1 - Calbiochem: のSDS（安全データシート）、CoA（試験成績書）およびCoQ（品質証明書）、カタログなど製品関連の技術資料を入手いただけます。

(M)SDS
試験成績書（CoA）
参考資料
Data Sheet

同義語: Compound P, L165041, 4-[3-(2-Propyl-3-hydroxy-4-acetyl)phenoxy]propyloxyphenoxy-acetic acid, PPAR Agonist VIII, PPARα Agonist III, PPARγ Agonist VII

Primary Target: Peroxisome proliferator activator receptor δ (PPAR@delta;)

View This Product on Sigma-Aldrich

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概要

Replacement Information

主要スペック表

CAS #	Empirical Formula
79558-09-1	C₂₂H₂₆O₇

価格＆在庫状況

カタログ番号	在庫状況	包装	Qty/Pk	価格	数量
422175-5MGCN	在庫状況検索中… — 現在国内在庫なし現在国内在庫有り販売中止在庫僅少現在国内在庫あり在庫を照会するにはログインしてください現在国内在庫有り現在国内在庫なし現在国内在庫有り Remaining : Will advise Remaining : Will advise 注文対象外お問合せください Contact Customer Service お問合せくださいお問合せください	樹脂ｱﾝﾌﾟﾙ	5 mg	価格を検索中… 価格が見つかりません Minimum Quantity needs to be mulitiple of Maximum Quantity is 弊社照会詳細を表示　値引 () — 弊社照会納入価格を閲覧するにはログインしてください	在庫状況を照会 —	お気に入り/ショッピングリストに追加お気に入り/ショッピングリストに追加お気に入りに追加されました

Description
Overview	A cell-permeable phenoxyacetic acid derivative that acts as a potent and selective peroxisome proliferator activator receptor δ (PPARδ) agonist (K_i = 6 nM for hPPARδ and 730 nM for hPPARγ). Potently induces adipocyte differentiation in NIH-PPARδ cells at 500 nM and raises total cholesterol in insulin resistant db/db mice without altering glucose or triglycerides levels. Increases UCP3 (uncoupling protein 3) gene expression in L6 myotubes. Inhibits cytokine-induced expression of VCAM-1 (vascular cell adhesion molecule-1) and the secretion of MCP-1 (monocyte chemotactic protein-1) in EAhy926 cells.
Catalogue Number	422175
Brand Family	Calbiochem®
Synonyms	Compound P, L165041, 4-[3-(2-Propyl-3-hydroxy-4-acetyl)phenoxy]propyloxyphenoxy-acetic acid, PPAR Agonist VIII, PPARα Agonist III, PPARγ Agonist VII

References
References	Rival, Y., et al. 2002. Eur. J. Pharmacol. 435, 143. Castrillo, A., et al. 2001. J. Biol. Chem. 276, 34082. Hansen, J.B., et al. 2001. J. Biol. Chem. 276, 3175. Son, C., et al. 2001. Endocrinology 142, 4189. Wilkie, N., et al. 2001. J. Neurochem. 78, 1135. Leibowitz, M.D., et al. 2000. FEBS Lett. 473, 333. Berger, J., et al. 1999. J. Biol. Chem. 274, 6718. Lim, H., et al. 1999. Genes Dev. 13, 1561.

References

Rival, Y., et al. 2002. Eur. J. Pharmacol. 435, 143.
Castrillo, A., et al. 2001. J. Biol. Chem. 276, 34082.
Hansen, J.B., et al. 2001. J. Biol. Chem. 276, 3175.
Son, C., et al. 2001. Endocrinology 142, 4189.
Wilkie, N., et al. 2001. J. Neurochem. 78, 1135.
Leibowitz, M.D., et al. 2000. FEBS Lett. 473, 333.
Berger, J., et al. 1999. J. Biol. Chem. 274, 6718.
Lim, H., et al. 1999. Genes Dev. 13, 1561.

Product Information
CAS number	79558-09-1
ATP Competitive	N
Form	White solid
Hill Formula	C₂₂H₂₆O₇
Chemical formula	C₂₂H₂₆O₇
Reversible	N
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Primary Target	Peroxisome proliferator activator receptor δ (PPAR@delta;)
Primary Target K<sub>i</sub>	6 nM for hPPARδ and 730 nM for hPPARγ
Purity	≥98% by HPLC

Physicochemical Information
Cell permeable	Y

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Irritant
Storage	+2°C to +8°C
Protect from Light	Protect from light
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
カタログ番号	GTIN
422175-5MGCN	04055977187144

Documentation

L-165,041 - CAS 79558-09-1 - Calbiochem (M)SDS

タイトル
英語版製品安全データシート（(M)SDS）

L-165,041 - CAS 79558-09-1 - Calbiochem 試験成績書（CoA）

タイトル	ロット番号
422175	ロット番号を入力

参考資料

参考資料の概要
Rival, Y., et al. 2002. Eur. J. Pharmacol. 435, 143. Castrillo, A., et al. 2001. J. Biol. Chem. 276, 34082. Hansen, J.B., et al. 2001. J. Biol. Chem. 276, 3175. Son, C., et al. 2001. Endocrinology 142, 4189. Wilkie, N., et al. 2001. J. Neurochem. 78, 1135. Leibowitz, M.D., et al. 2000. FEBS Lett. 473, 333. Berger, J., et al. 1999. J. Biol. Chem. 274, 6718. Lim, H., et al. 1999. Genes Dev. 13, 1561.

参考資料の概要

データシート

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	05-August-2008 RFH
Synonyms	Compound P, L165041, 4-[3-(2-Propyl-3-hydroxy-4-acetyl)phenoxy]propyloxyphenoxy-acetic acid, PPAR Agonist VIII, PPARα Agonist III, PPARγ Agonist VII
Description	A cell-permeable phenoxyacetic acid derivative that acts as a potent and selective peroxisome proliferator activator receptor δ (PPARδ) agonist (K_i = 6 nM for hPPAR δ and 730 nM for hPPARγ). Induces adipocyte differentiation in NIH-PPARδ cells at 500 nM. Also reported to raise total cholesterol in insulin-resistant db/db mice without altering glucose or triglyceride levels. Shown to increase uncoupling protein 3 (UCP3) gene expression in L6 myotubes. Also shown to inhibit cytokine-induced expression of vascular cell adhesion molecule-1 (VCAM-1) and the secretion of monocyte chemotactic protein-1 (MCP-1) in Eahy926 cells.
Form	White solid
Intert gas (Yes/No)	Packaged under inert gas
CAS number	79558-09-1
Chemical formula	C₂₂H₂₆O₇
Structure formula
Purity	≥98% by HPLC
Solubility	DMSO (5 mg/ml) or 1 N NaOH (40 mg/ml)
Storage	Protect from light +2°C to +8°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity	Irritant
References	Rival, Y., et al. 2002. Eur. J. Pharmacol. 435, 143. Castrillo, A., et al. 2001. J. Biol. Chem. 276, 34082. Hansen, J.B., et al. 2001. J. Biol. Chem. 276, 3175. Son, C., et al. 2001. Endocrinology 142, 4189. Wilkie, N., et al. 2001. J. Neurochem. 78, 1135. Leibowitz, M.D., et al. 2000. FEBS Lett. 473, 333. Berger, J., et al. 1999. J. Biol. Chem. 274, 6718. Lim, H., et al. 1999. Genes Dev. 13, 1561.

カテゴリー

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Activators > Peroxisome Proliferator Activated Receptor (PPAR) Agonists

製品がカートに追加されました

422175 Sigma-AldrichL-165,041 - CAS 79558-09-1 - Calbiochem

A cell-permeable phenoxyacetic acid derivative that acts as a potent and selective peroxisome proliferator activator receptor δ (PPARδ) agonist (K_i = 6 nM for hPPARδ and 730 nM for hPPARγ).

同義語: Compound P, L165041, 4-[3-(2-Propyl-3-hydroxy-4-acetyl)phenoxy]propyloxyphenoxy-acetic acid, PPAR Agonist VIII, PPARα Agonist III, PPARγ Agonist VII

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概要

主要スペック表

価格＆在庫状況

Documentation

L-165,041 - CAS 79558-09-1 - Calbiochem (M)SDS

L-165,041 - CAS 79558-09-1 - Calbiochem 試験成績書（CoA）

参考資料

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A cell-permeable phenoxyacetic acid derivative that acts as a potent and selective peroxisome proliferator activator receptor δ (PPARδ) agonist (Ki = 6 nM for hPPARδ and 730 nM for hPPARγ).

同義語: Compound P, L165041, 4-[3-(2-Propyl-3-hydroxy-4-acetyl)phenoxy]propyloxyphenoxy-acetic acid, PPAR Agonist VIII, PPARα Agonist III, PPARγ Agonist VII

お勧めの製品

主要スペック表

価格＆在庫状況

L-165,041 - CAS 79558-09-1 - Calbiochem (M)SDS

L-165,041 - CAS 79558-09-1 - Calbiochem 試験成績書（CoA）

参考資料

カテゴリー

最近の閲覧履歴

A cell-permeable phenoxyacetic acid derivative that acts as a potent and selective peroxisome proliferator activator receptor δ (PPARδ) agonist (K_i = 6 nM for hPPARδ and 730 nM for hPPARγ).