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420600 Ketoconazole - CAS 65277-42-1 - Calbiochem

An inhibitor of cytochrome P-450 in steroid biosynthesis. An antifungal agent that displays potent anti-metastatic, anti-neoplastic, and anti-psoriatic activities.

Ketoconazole - CAS 65277-42-1 - Calbiochem: のSDS（安全データシート）、CoA（試験成績書）およびCoQ（品質証明書）、カタログなど製品関連の技術資料を入手いただけます。

同義語: cis-1-Acetyl-4-[4-[[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazine, R-41400, CYP17A1 Inhibitor I

Primary Target: 5-LO
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420600
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概要

Replacement Information

主要スペック表

CAS #Empirical Formula
65277-42-1C₂₆H₂₈Cl₂N₄O₄

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420600-50MGCN
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      		 ｶﾞﾗｽﾋﾞﾝ 50 mg
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      Description
      OverviewAn inhibitor of cytochrome P-450 in steroid biosynthesis. An antifungal agent that displays potent anti-metastatic, anti-neoplastic, and anti-psoriatic activities. Also acts as an inhibitor of 5-lipoxygenase (5-LO; IC50 = 26 µM) and thromboxane synthase activities.
      Catalogue Number420600
      Brand Family Calbiochem®
      Synonymscis-1-Acetyl-4-[4-[[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazine, R-41400, CYP17A1 Inhibitor I
      References
      Referencesvan Wauwe, J.P., and Janssen, P.A.J. 1989. J. Med. Chem. 32, 2231.
      Beetens, J.R., et al. 1986. Biochem. Pharmacol. 35, 883.
      Lambert, A., et al. 1986. Biochem. Pharmacol. 35, 3999.
      Tucker, W.F.G., and MacNeil, S. 1986. Br. Med. J. 293, 882.
      Lelcuk, S., et al. 1984. J. Trauma 24, 393.
      Product Information
      CAS number65277-42-1
      FormOff-white solid
      Hill FormulaC₂₆H₂₈Cl₂N₄O₄
      Chemical formulaC₂₆H₂₈Cl₂N₄O₄
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary Target5-LO
      Primary Target IC<sub>50</sub>26 µM
      Purity≥98% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSTK7912300
      Safety Information
      R PhraseR: 25-40-63-36/37/38

      Toxic if swallowed.
      Limited evidence of a carcinogenic effect.
      Possible risk of harm to the unborn child.
      Irritating to eyes, respiratory system and skin.
      S PhraseS: 22-26-36

      Do not breathe dust.
      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Wear suitable protective clothing.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Toxic & Carcinogenic / Teratogenic
      Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
      Storage +2°C to +8°C
      Do not freeze Ok to freeze
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      カタログ番号 GTIN
      420600-50MGCN 04055977187618

      Documentation

      Ketoconazole - CAS 65277-42-1 - Calbiochem (M)SDS

      タイトル

      英語版製品安全データシート（(M)SDS） 

      Ketoconazole - CAS 65277-42-1 - Calbiochem 試験成績書（CoA）

      タイトルロット番号
      420600

      参考資料

      参考資料の概要
      van Wauwe, J.P., and Janssen, P.A.J. 1989. J. Med. Chem. 32, 2231.
      Beetens, J.R., et al. 1986. Biochem. Pharmacol. 35, 883.
      Lambert, A., et al. 1986. Biochem. Pharmacol. 35, 3999.
      Tucker, W.F.G., and MacNeil, S. 1986. Br. Med. J. 293, 882.
      Lelcuk, S., et al. 1984. J. Trauma 24, 393.
      データシート

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision13-May-2008 RFH
      Synonymscis-1-Acetyl-4-[4-[[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazine, R-41400, CYP17A1 Inhibitor I
      DescriptionAn inhibitor of cytochrome P-450 in steroid biosynthesis. An anti-fungal agent that displays potent anti-metastatic, anti-neoplastic, and anti-psoriatic activities. Also acts as an inhibitor of 5-lipoxygenase (5-LO; IC50 = 26 µM) and thromboxane synthase activities.
      FormOff-white solid
      CAS number65277-42-1
      RTECSTK7912300
      Chemical formulaC₂₆H₂₈Cl₂N₄O₄
      Structure formulaStructure formula
      Purity≥98% by HPLC
      Storage +2°C to +8°C
      Do Not Freeze Ok to freeze
      Toxicity Toxic & Carcinogenic / Teratogenic
      Merck USA index14, 5302
      Referencesvan Wauwe, J.P., and Janssen, P.A.J. 1989. J. Med. Chem. 32, 2231.
      Beetens, J.R., et al. 1986. Biochem. Pharmacol. 35, 883.
      Lambert, A., et al. 1986. Biochem. Pharmacol. 35, 3999.
      Tucker, W.F.G., and MacNeil, S. 1986. Br. Med. J. 293, 882.
      Lelcuk, S., et al. 1984. J. Trauma 24, 393.