420136 Sigma-AldrichJNK Inhibitor IX - CAS 312917-14-9 - Calbiochem
The JNK Inhibitor IX, also referenced under CAS 312917-14-9, controls the biological activity of JNK. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applic
More>> The JNK Inhibitor IX, also referenced under CAS 312917-14-9, controls the biological activity of JNK. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Less<<同義語: N-(3-Cyano-4,5,6,7-tetrahydro-1-benzothien-2-yl)-1-naphthamide
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概要
主要スペック表
CAS # | Empirical Formula |
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312917-14-9 | C₂₀H₁₆N₂OS • H₂O |
価格&在庫状況
カタログ番号 | 在庫状況 | 包装 | Qty/Pk | 価格 | 数量 | |
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420136-5MGCN |
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樹脂アンプル | 5 mg |
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Description | |
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Overview | A thienylnaphthamide compound that acts as a potent and ATP binding site-targeting inhibitor of JNK2 and JNK3 (pIC50 = 6.5 and 6.7, respectively) with little or no activity against JNK1, p38α, and a panel of more than 30 other kinases (pIC50 <5.0). In contrast, SP600125 (Cat. Nos. 420119 and 420128) offers little selectivity between JNK1 and JNK3 (pIC50 = 6.4 and 5.9, respectively) under the same assay conditions. |
Catalogue Number | 420136 |
Brand Family | Calbiochem® |
Synonyms | N-(3-Cyano-4,5,6,7-tetrahydro-1-benzothien-2-yl)-1-naphthamide |
References | |
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References | Angell, R.M., et al. 2007. Bioorg. Med. Chem. Lett. 17, 1296. |
Product Information | |
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CAS number | 312917-14-9 |
ATP Competitive | Y |
Form | Tan solid |
Hill Formula | C₂₀H₁₆N₂OS • H₂O |
Chemical formula | C₂₀H₁₆N₂OS • H₂O |
Reversible | N |
Structure formula Image | |
Quality Level | MQ100 |
Biological Information | |
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Primary Target | JNK2 and JNK3 |
Primary Target IC<sub>50</sub> | pIC50 = 6.5 and 6.7, against JNK2 and JNK3, respectively |
Purity | ≥95% by HPLC |
Physicochemical Information | |
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Cell permeable | N |
Packaging Information | |
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Packaged under inert gas | Packaged under inert gas |
Global Trade Item Number | |
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カタログ番号 | GTIN |
420136-5MGCN | 04055977187663 |