420202 Sigma-AldrichJMJD Histone Demethylase Inhibitor III - CAS 1310809-17-6 - Calbiochem
The JMJD Histone Demethylase Inhibitor III controls the biological activity of JMJD Histone Demethylase. This small molecule/inhibitor is primarily used for Cell Structure applications.
More>> The JMJD Histone Demethylase Inhibitor III controls the biological activity of JMJD Histone Demethylase. This small molecule/inhibitor is primarily used for Cell Structure applications. Less<<JMJD Histone Demethylase Inhibitor III - CAS 1310809-17-6 - Calbiochem: のSDS（安全データシート）、CoA（試験成績書）およびCoQ（品質証明書）、カタログなど製品関連の技術資料を入手いただけます。
同義語: JHDM Inhibitor III, Histone Lysine Demethylase Inhibitor X, (E)-4-(Hydroxy(4-(4-((naphthalen-1-ylcarbamoyloxy)methyl)benzylamino)butyl)amino)-4-oxobut-2-enoic acid
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概要
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主要スペック表
| CAS # | Empirical Formula |
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| 1310809-17-6 | C₂₇H₂₉N₃O₆ |
価格＆在庫状況
| カタログ番号 | 在庫状況 | 包装 | Qty/Pk | 価格 | 数量 | |
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| 420202-5MGCN |
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ｶﾞﾗｽﾋﾞﾝ | 5 mg |
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| Description | |
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| Overview | A substrate (methyl lysine) and cofactor (α-ketoglutarate) mimicking bivalent benzylamino-butylamino-N-hydroxybutenoic acid compound that acts as a selective in vitro inhibitor of Jumonji domain-containing histone demethylases (JHDMs; IC50 = 4.3, 3.4, 5.9, 10 and 43 µM for JMJD2A, JMJD2C, JMJD2E, PHF8 and JMJD3, respectively) over LSD1, asparaginyl and prolyl hydroxylases, and histone deacetylases (IC50 = 54, 83, 31, 22, 620, 680 and >800 µM for PHD1, PHD2, PHD3, FIH, LSD1 and HDACs, respectively). The cellular active JHDM Inhibitor, Methylstat is also available (Cat. No. 420203). |
| Catalogue Number | 420202 |
| Brand Family | Calbiochem® |
| Synonyms | JHDM Inhibitor III, Histone Lysine Demethylase Inhibitor X, (E)-4-(Hydroxy(4-(4-((naphthalen-1-ylcarbamoyloxy)methyl)benzylamino)butyl)amino)-4-oxobut-2-enoic acid |
| References | |
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| References | Luo, X., et al. 2011. J. Am. Chem. Soc. 133, 9451. |
| Product Information | |
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| CAS number | 1310809-17-6 |
| Form | Off-white powder |
| Hill Formula | C₂₇H₂₉N₃O₆ |
| Chemical formula | C₂₇H₂₉N₃O₆ |
| Structure formula Image | |
| Quality Level | MQ100 |
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| Biological Information | |
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| Purity | ≥95% by HPLC |
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| Packaging Information | |
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| Packaged under inert gas | Packaged under inert gas |
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| Specifications |
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| Global Trade Item Number | |
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| カタログ番号 | GTIN |
| 420202-5MGCN | 04055977210767 |
Documentation
JMJD Histone Demethylase Inhibitor III - CAS 1310809-17-6 - Calbiochem (M)SDS
| タイトル |
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JMJD Histone Demethylase Inhibitor III - CAS 1310809-17-6 - Calbiochem 試験成績書（CoA）
| タイトル | ロット番号 |
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| 420202 |
参考資料
| 参考資料の概要 |
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| Luo, X., et al. 2011. J. Am. Chem. Soc. 133, 9451. |
技術情報
| タイトル |
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| White Paper - The Message in the Marks: Deciphering Cancer Epigenetics |
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Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
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