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402088 Indirubin-3ʹ-monoxime-5-sulphonic Acid - CAS 331467-05-1 - Calbiochem

A potent, reversible, and selective inhibitor of Cdk1 (IC₅₀ = 5 nM) and Cdk5 (IC₅₀ = 7 nM) and glycogen synthase kinase-3β (GSK-3β; IC₅₀ = 80 nM).

Indirubin-3ʹ-monoxime-5-sulphonic Acid - CAS 331467-05-1 - Calbiochem: のSDS（安全データシート）、CoA（試験成績書）およびCoQ（品質証明書）、カタログなど製品関連の技術資料を入手いただけます。
Primary Target: CDK1
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402088
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概要

Replacement Information

主要スペック表

CAS #Empirical Formula
331467-05-1C₁₆H₁₁N₃O₅S

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402088-1MGCN
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      Description
      OverviewA potent, reversible, and selective inhibitor of Cdk1 (IC50 = 5 nM) and Cdk5 (IC50 = 7 nM) and glycogen synthase kinase-3β (GSK-3β; IC50 = 80 nM). The inhibition is competitive with respect to ATP.
      Catalogue Number402088
      Brand Family Calbiochem®
      References
      ReferencesLeclerc, S., et al. 2001. J. Biol. Chem. 276, 251.
      Product Information
      CAS number331467-05-1
      ATP CompetitiveY
      FormDark red solid
      Hill FormulaC₁₆H₁₁N₃O₅S
      Chemical formulaC₁₆H₁₁N₃O₅S
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetCDK1
      Primary Target IC<sub>50</sub>5 nM, 7 nM, 80 nM, against Cdk1, Cdk5, and glycogen synthase kinase-3β (GSK-3β), respectively
      Purity≥97% by HPLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 4 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      カタログ番号 GTIN
      402088-1MGCN 04055977211801

      Documentation

      Indirubin-3ʹ-monoxime-5-sulphonic Acid - CAS 331467-05-1 - Calbiochem (M)SDS

      タイトル

      英語版製品安全データシート（(M)SDS） 

      Indirubin-3ʹ-monoxime-5-sulphonic Acid - CAS 331467-05-1 - Calbiochem 試験成績書（CoA）

      タイトルロット番号
      402088

      参考資料

      参考資料の概要
      Leclerc, S., et al. 2001. J. Biol. Chem. 276, 251.

      カタログ

      タイトル
      Alzheimer's Disease Brochure & Technical Guide
      データシート

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision13-April-2011 RFH
      DescriptionA highly potent, reversible, and selective inhibitor of cyclin-dependent kinases 1 and 5 (IC50 = 5 nM for CDK1; IC50 = 7 nM for CDK5). Reported to act by competing with ATP for binding to the catalytic site of the kinase. Also acts as a potent inhibitor of glycogen synthase kinase-3β (GSK-3β; IC50 = 80 nM).
      FormDark red solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number331467-05-1
      Chemical formulaC₁₆H₁₁N₃O₅S
      Structure formulaStructure formula
      Purity≥97% by HPLC
      SolubilityDMSO (50 mg/ml)
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 4 months at -20°C.
      Toxicity Standard Handling
      ReferencesLeclerc, S., et al. 2001. J. Biol. Chem. 276, 251.