数量	カタログ番号	注文内容	Qty/Pk	価格
			96-Well Plate

数量	カタログ番号	注文内容	Qty/Pk	価格
	48-602MAG	Buffer Detection Kit for Magnetic Beads	1 Kit

565771 Sigma-AldrichInSolution™ γ-Secretase Inhibitor X - Calbiochem

InSolution™ γ-Secretase Inhibitor X is a 1 mM solution in DMSO. A highly potent inhibitor of g-secretase (IC₅₀ = 17, 48, 67 nM for Aβtotal, Aβ40 & Aβ42 in SHSY5Y cells overexpressing spβA4CTF).

InSolution™ γ-Secretase Inhibitor X - Calbiochem: のSDS（安全データシート）、CoA（試験成績書）およびCoQ（品質証明書）、カタログなど製品関連の技術資料を入手いただけます。

(M)SDS
試験成績書（CoA）
参考資料
Data Sheet

同義語: L-685,458, {1S-Benzyl-4R-[1-(1S-carbamoyl-2-phenethylcarbamoyl)-1S-3-methylbutylcarbamoyl]-2R-hydroxy-5-phenylpentyl}carbamic Acid tert-butyl Ester

Primary Target: Aβ_total

View This Product on Sigma-Aldrich

お勧めの製品

概要

Replacement Information

主要スペック表

Empirical Formula
C₃₉H₅₂N₄O₆

価格＆在庫状況

カタログ番号	在庫状況	包装	Qty/Pk	価格	数量
565771-250UGCN	在庫状況検索中… — 現在国内在庫なし現在国内在庫有り販売中止在庫僅少現在国内在庫あり在庫を照会するにはログインしてください現在国内在庫有り現在国内在庫なし現在国内在庫有り Remaining : Will advise Remaining : Will advise 注文対象外お問合せください Contact Customer Service お問合せくださいお問合せください	樹脂ｱﾝﾌﾟﾙ	250 μg	価格を検索中… 価格が見つかりません Minimum Quantity needs to be mulitiple of Maximum Quantity is 弊社照会詳細を表示　値引 () — 弊社照会納入価格を閲覧するにはログインしてください	在庫状況を照会 —	お気に入り/ショッピングリストに追加お気に入り/ショッピングリストに追加お気に入りに追加されました
565771-500UGCN	在庫状況検索中… — 現在国内在庫なし現在国内在庫有り販売中止在庫僅少現在国内在庫あり在庫を照会するにはログインしてください現在国内在庫有り現在国内在庫なし現在国内在庫有り Remaining : Will advise Remaining : Will advise 注文対象外お問合せください Contact Customer Service お問合せくださいお問合せください	樹脂ｱﾝﾌﾟﾙ	500 μg	価格を検索中… 価格が見つかりません Minimum Quantity needs to be mulitiple of Maximum Quantity is 弊社照会詳細を表示　値引 () — 弊社照会納入価格を閲覧するにはログインしてください	在庫状況を照会 —	お気に入り/ショッピングリストに追加お気に入り/ショッピングリストに追加お気に入りに追加されました

Description
Overview	A cell-permeable hydroxyethylene dipeptide isostere that acts as a highly specific and a potent inhibitor of γ-secretase (Aβ_total IC₅₀ = 17 nM, Aβ₄₀ IC₅₀ = 48 nM, and Aβ₄₂ IC₅₀ = 67 nM in SHSY5Y cells overexpressing spβA4CTF). Binds to presenilin and blocks Notch intracellular domain production. Functions as a transition state analog mimic at the catalytic site of an aspartyl protease, however, it exhibits over 100-fold greater selectivity for γ-secretase than for cathepsin D.
Catalogue Number	565771
Brand Family	Calbiochem®
Synonyms	L-685,458, {1S-Benzyl-4R-[1-(1S-carbamoyl-2-phenethylcarbamoyl)-1S-3-methylbutylcarbamoyl]-2R-hydroxy-5-phenylpentyl}carbamic Acid tert-butyl Ester

References
References	Weidemann, A., et al. 2002. Biochemistry 41, 2825. Doerfler, P., et al. 2001. Proc. Natl. Acad. Sci. USA 98, 9312. Li, Y.M., et al. 2000. Proc. Natl. Acad. Sci. USA 97, 6138. Shearman, M.S., et al. 2000. Biochemistry 39, 8698.

Product Information
ATP Competitive	N
Form	Liquid
Formulation	A 1 mM (250 µg in 372 µl or 500 µg in 744 µl) solution in DMSO.
Hill Formula	C₃₉H₅₂N₄O₆
Chemical formula	C₃₉H₅₂N₄O₆
Reversible	N
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Primary Target	Aβ_total
Primary Target IC<sub>50</sub>	Aβtotal 17 nM, Aβ40 48 nM, and Aβ42 67 nM in SHSY5Y cells overexpressing spβA4CTF
Purity	≥90% by HPLC

Physicochemical Information
Cell permeable	Y

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Standard Handling
Storage	-20°C
Protect from Light	Protect from light
Protect from Moisture	Protect from moisture
Do not freeze	Ok to freeze
Special Instructions	Following initial thaw, aliquot and freeze (-20°C).

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
カタログ番号	GTIN
565771-250UGCN	04055977267839
565771-500UGCN	04055977267846

Documentation

InSolution™ γ-Secretase Inhibitor X - Calbiochem (M)SDS

タイトル
英語版製品安全データシート（(M)SDS）

InSolution™ γ-Secretase Inhibitor X - Calbiochem 試験成績書（CoA）

タイトル	ロット番号
565771	ロット番号を入力

参考資料

参考資料の概要
Weidemann, A., et al. 2002. Biochemistry 41, 2825. Doerfler, P., et al. 2001. Proc. Natl. Acad. Sci. USA 98, 9312. Li, Y.M., et al. 2000. Proc. Natl. Acad. Sci. USA 97, 6138. Shearman, M.S., et al. 2000. Biochemistry 39, 8698.

データシート

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	10-September-2008 RFH
Synonyms	L-685,458, {1S-Benzyl-4R-[1-(1S-carbamoyl-2-phenethylcarbamoyl)-1S-3-methylbutylcarbamoyl]-2R-hydroxy-5-phenylpentyl}carbamic Acid tert-butyl Ester
Description	A cell-permeable hydroxyethylene dipeptide isostere that acts as a potent and highly specific inhibitor of γ-secretase (Aβ total IC₅₀ = 17 nM; Aβ₄₀ IC₅₀ = 48 nM; and Aβ₄₂ IC₅₀ = 67 nM in SH-SY5Y cells overexpressing spβA4CTF). Binds to presenilin and blocks Notch intracellular domain production. Also reported to block the formation of εCTF, resulting in the accumulation of α- and βCTF. Functions as a transition state analog mimic at the catalytic site of an aspartyl protease, however, it exhibits over 100-fold greater selectivity for γ-secretase than for cathepsin D.
Form	Liquid
Formulation	A 1 mM (250 µg in 372 µl or 500 µg in 744 µl) solution in DMSO.
Intert gas (Yes/No)	Packaged under inert gas
Chemical formula	C₃₉H₅₂N₄O₆
Structure formula
Purity	≥90% by HPLC
Storage	Protect from moisture Protect from light -20°C
Do Not Freeze	Ok to freeze
Special Instructions	Following initial thaw, aliquot and freeze (-20°C).
Toxicity	Standard Handling
References	Weidemann, A., et al. 2002. Biochemistry 41, 2825. Doerfler, P., et al. 2001. Proc. Natl. Acad. Sci. USA 98, 9312. Li, Y.M., et al. 2000. Proc. Natl. Acad. Sci. USA 97, 6138. Shearman, M.S., et al. 2000. Biochemistry 39, 8698.

カテゴリー

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Neurobiology / Neurodegeneration > Secretase Inhibitors

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