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553211 InSolution™ Rapamycin - Calbiochem

This product can no longer be ordered through emdmillipore.com. Please refer to (Cat. No. 553211) on sigmaaldrich.com.

InSolution™ Rapamycin - Calbiochem: のSDS（安全データシート）、CoA（試験成績書）およびCoQ（品質証明書）、カタログなど製品関連の技術資料を入手いただけます。

同義語: mTOR Inhibitor I

Primary Target: Mammalian target of rapamycin (mTOR)
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553211
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概要

Replacement Information

主要スペック表

Empirical Formula
C₅₁H₇₉NO₁₃

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カタログ番号 在庫状況包装 Qty/Pk 価格 数量
553211-1MGCN
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      		 樹脂ｱﾝﾌﾟﾙ 1 mg
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      553211-500UGCN
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          		 樹脂ｱﾝﾌﾟﾙ 500 μg
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          Description
          Catalogue Number553211
          Brand Family Calbiochem®
          SynonymsmTOR Inhibitor I
          References
          Product Information
          ATP CompetitiveN
          FormLiquid
          FormulationA 5 mM (500 µg/109 µl) solution of Rapamycin (Cat. No. 553210) in DMSO.
          Hill FormulaC₅₁H₇₉NO₁₃
          Chemical formulaC₅₁H₇₉NO₁₃
          Hygroscopic Hygroscopic
          ReversibleN
          Structure formula ImageStructure formula Image
          Quality LevelMQ100
          Applications
          Biological Information
          Primary TargetMammalian target of rapamycin (mTOR)
          Primary Target IC<sub>50</sub>50 pM inhibiting the mammalian target of rapamycin (mTOR) and blocking the subsequent activation of p70 S6 kinase
          Purity≥98% by TLC
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped with Blue Ice or with Dry Ice
          Toxicity Irritant
          Storage -20°C
          Protect from Light Protect from light
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing initial use, aliquot and freeze (-20°C).
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications
          Global Trade Item Number
          カタログ番号 GTIN
          553211-1MGCN 04055977193541
          553211-500UGCN 04055977193558

          Documentation

          InSolution™ Rapamycin - Calbiochem (M)SDS

          タイトル

          英語版製品安全データシート（(M)SDS） 

          InSolution™ Rapamycin - Calbiochem 試験成績書（CoA）

          タイトルロット番号
          553211

          引用

          Title
        • Yung-Luen Yu, et al. (2005) MAP kinase-mediated phosphorylation of GATA-1 promotes Bcl-XL expression and cell survival. Journal of Biological Chemistry 280, 29533-29542.
        • Rick B. Vega, et al. (2004) Protein Kinases C and D Mediate Agonist-Dependent Cardiac Hypertrophy through Nuclear Export of Histone Deacetylase 5. Molecular and Cellular Biology 24, 8374-8385.
        • Xinbo Liao, et al. (2003) Androgen stimulates matrix metalloproteinase-2 expression in human prostate cancer. Endocrinology 144, 1656-1663.
          		•
          データシート

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision09-September-2008 RFH
          SynonymsmTOR Inhibitor I
          DescriptionSelectively inhibits the phosphorylation and activation of p70 S6 kinase (IC50 = 50 pM). Prevents the translational activation of IGF-II. Also prevents resting T-cells from entering the cell cycle, but does not directly arrest cell cycle progression. Shown to inhibit later signaling events, such as p110Rb phosphorylation, p34cdc2 kinase activation, and cyclin A synthesis. Exhibits strong binding to FK-506 binding proteins. Also reported to induce apoptosis in a murine B-cell line, to inhibit lymphokine-induced cell proliferation at the G1 phase, and to irreversibly arrest Saccharomyces cerevisiae cells in the G1 phase.
          FormLiquid
          FormulationA 5 mM (500 µg/109 µl) solution of Rapamycin (Cat. No. 553210) in DMSO.
          Intert gas (Yes/No) Packaged under inert gas
          Chemical formulaC₅₁H₇₉NO₁₃
          Structure formulaStructure formula
          Purity≥98% by TLC
          Storage Protect from light
          -20°C
          Hygroscopic
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing initial use, aliquot and freeze (-20°C).
          Toxicity Irritant
          Citation
        • Yung-Luen Yu, et al. (2005) MAP kinase-mediated phosphorylation of GATA-1 promotes Bcl-XL expression and cell survival. Journal of Biological Chemistry 280, 29533-29542.
        • Rick B. Vega, et al. (2004) Protein Kinases C and D Mediate Agonist-Dependent Cardiac Hypertrophy through Nuclear Export of Histone Deacetylase 5. Molecular and Cellular Biology 24, 8374-8385.
        • Xinbo Liao, et al. (2003) Androgen stimulates matrix metalloproteinase-2 expression in human prostate cancer. Endocrinology 144, 1656-1663.
          		•