数量	カタログ番号	注文内容	Qty/Pk	価格
			96-Well Plate

数量	カタログ番号	注文内容	Qty/Pk	価格
	48-602MAG	Buffer Detection Kit for Magnetic Beads	1 Kit

496000 Sigma-AldrichInSolution™ OM99-2 - CAS 314266-76-7 - Calbiochem

An eight residue peptidomimetic, tight binding transition-state analog inhibitor of human brain memapsin 2.

InSolution™ OM99-2 - CAS 314266-76-7 - Calbiochem: のSDS（安全データシート）、CoA（試験成績書）およびCoQ（品質証明書）、カタログなど製品関連の技術資料を入手いただけます。

(M)SDS
試験成績書（CoA）
参考資料
Data Sheet

同義語: EVNLΨAAEF

Primary Target: human brain memapsin 2

View This Product on Sigma-Aldrich

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概要

Replacement Information

主要スペック表

CAS #	Empirical Formula
314266-76-7	C₄₁H₆₄N₈O₁₄

価格＆在庫状況

カタログ番号	在庫状況	包装	Qty/Pk	価格	数量
496000-250UGCN	在庫状況検索中… — 現在国内在庫なし現在国内在庫有り販売中止在庫僅少現在国内在庫あり在庫を照会するにはログインしてください現在国内在庫有り現在国内在庫なし現在国内在庫有り Remaining : Will advise Remaining : Will advise 注文対象外お問合せください Contact Customer Service お問合せくださいお問合せください	樹脂ｱﾝﾌﾟﾙ	250 μg	価格を検索中… 価格が見つかりません Minimum Quantity needs to be mulitiple of Maximum Quantity is 弊社照会詳細を表示　値引 () — 弊社照会納入価格を閲覧するにはログインしてください	在庫状況を照会 —	お気に入り/ショッピングリストに追加お気に入り/ショッピングリストに追加お気に入りに追加されました

Description
Overview	An eight residue peptidomimetic, tight binding transition-state analog inhibitor of human brain memapsin 2 (K_i = 1.6 nM, recombinant memapsin 2; K_i = 9.58 nM, recombinant pro-memapsin 2). Also inhibits cathepsin D (K_i = 48 nM). This aspartyl protease inhibitor is designed from the template of the β-secretase site of Swedish β-amyloid precursor protein (APP) with Asp to Ala replacement; also includes a nonhydrolyzable hydroxyethylene isostere between Leu and Ala.
Catalogue Number	496000
Brand Family	Calbiochem®
Synonyms	EVNLΨAAEF

References
References	Ghosh, A.K., et al. 2001. J. Med. Chem. 44, 2865. Turner III, R.T., et al. 2001. Biochemistry 40, 10001. Ghosh, A.K., et al. 2000. J. Am. Chem. Soc. 122, 3522. Hong, L., et al. 2000. Science 290,150.

Product Information
CAS number	314266-76-7
ATP Competitive	N
Form	Liquid
Formulation	A 1 mM (250µg in 280 µl) solution in DMSO. Supplied as a trifluoroacetate salt.
Hill Formula	C₄₁H₆₄N₈O₁₄
Chemical formula	C₄₁H₆₄N₈O₁₄
Reversible	N
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Primary Target	human brain memapsin 2
Primary Target K<sub>i</sub>	1.6 nM against recombinant memapsin 2; 9.58 nM against recombinant pro-memapsin 2; 48 nM against cathepsin D
Purity	≥90% by HPLC

Physicochemical Information
Cell permeable	N
Peptide Sequence	Glu-Val-Asn-Leu-Ψ-Ala-Ala-Glu-Phe [Ψ denotes replacement of CONH by (S)-CH(OH)CH₂]

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Standard Handling
Storage	-20°C
Protect from Light	Protect from light
Protect from Moisture	Protect from moisture
Do not freeze	Ok to freeze
Special Instructions	Following initial thaw, aliquot and freeze (-20°C). Avoid freeze/thaw cycles of solutions.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
カタログ番号	GTIN
496000-250UGCN	04055977199826

Documentation

InSolution™ OM99-2 - CAS 314266-76-7 - Calbiochem (M)SDS

タイトル
英語版製品安全データシート（(M)SDS）

InSolution™ OM99-2 - CAS 314266-76-7 - Calbiochem 試験成績書（CoA）

タイトル	ロット番号
496000	ロット番号を入力

参考資料

参考資料の概要
Ghosh, A.K., et al. 2001. J. Med. Chem. 44, 2865. Turner III, R.T., et al. 2001. Biochemistry 40, 10001. Ghosh, A.K., et al. 2000. J. Am. Chem. Soc. 122, 3522. Hong, L., et al. 2000. Science 290,150.

データシート

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	13-August-2008 RFH
Synonyms	EVNLΨAAEF
Description	A peptidomimetic, highly potent, tight-binding transition-state analog inhibitor of human brain β-secretase (K_i = 1.6 nM, recombinant memapsin-2; K_i = 9.58 nM, recombinant pro-memapsin 2). Designed from the template of the β-secretase site of Swedish β-amyloid precursor protein (APP) with Asp to Ala replacement. Includes a nonhydrolyzable hydroxyethylene isostere between Leu and Ala. Also reported to inhibit cathepsin D at higher levels (K_i = 48 nM).
Form	Liquid
Formulation	A 1 mM (250µg in 280 µl) solution in DMSO. Supplied as a trifluoroacetate salt.
Intert gas (Yes/No)	Packaged under inert gas
CAS number	314266-76-7
Chemical formula	C₄₁H₆₄N₈O₁₄
Peptide Sequence	Glu-Val-Asn-Leu-Ψ-Ala-Ala-Glu-Phe [Ψ denotes replacement of CONH by (S)-CH(OH)CH₂]
Structure formula
Purity	≥90% by HPLC
Storage	Protect from moisture Protect from light -20°C
Do Not Freeze	Ok to freeze
Special Instructions	Following initial thaw, aliquot and freeze (-20°C). Avoid freeze/thaw cycles of solutions.
Toxicity	Standard Handling
References	Ghosh, A.K., et al. 2001. J. Med. Chem. 44, 2865. Turner III, R.T., et al. 2001. Biochemistry 40, 10001. Ghosh, A.K., et al. 2000. J. Am. Chem. Soc. 122, 3522. Hong, L., et al. 2000. Science 290,150.

カテゴリー

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Neurobiology / Neurodegeneration > Secretase Inhibitors

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