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487929 InSolution™ Nocodazole - CAS 31430-18-9 - Calbiochem

Inhibitor of mitosis. Has highly specific antimicrotubular activity for mammalian cells in culture.

InSolution™ Nocodazole - CAS 31430-18-9 - Calbiochem: のSDS（安全データシート）、CoA（試験成績書）およびCoQ（品質証明書）、カタログなど製品関連の技術資料を入手いただけます。

同義語: Methyl-(5-(2-thienylcarbonyl)-1H-benzimidazol-2-yl)-carbamate, Methyl-5-(thiophene-2-carbonyl)-1H-benzo[d]imidazol-2-ylcarbamate, R17934

Primary Target: Microtubules
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487929
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概要

主要スペック表

CAS #Empirical Formula
31430-18-9C₁₄H₁₁N₃O₃S

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487929-10MGCN
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      		 ｶﾞﾗｽﾋﾞﾝ 10 mg
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      Description
      OverviewInhibitor of mitosis. Has highly specific antimicrotubular activity for mammalian cells in culture. Promotes tubulin depolymerization. Also acts as a high-affinity ligand for the cancer-related kinases ABL, c-KIT, BRAF, and MEK (Kd < 2 µM). The solid form of this compound (Cat. No. 487928) is also available.
      Catalogue Number487929
      Brand Family Calbiochem®
      SynonymsMethyl-(5-(2-thienylcarbonyl)-1H-benzimidazol-2-yl)-carbamate, Methyl-5-(thiophene-2-carbonyl)-1H-benzo[d]imidazol-2-ylcarbamate, R17934
      References
      ReferencesPark, H., et al. 2012. Chem. Med. Chem. 7, 53.
      Bunz, F., et al. 1998. Science 282, 1497.
      Fleischman, L.F., et al. 1993. Oncogene 8, 771. Pomies, P., and Block, M.R. 1992. Biochem. Biophys. Res. Commun. 189, 1429.
      Rennison, M.E., et al. 1992. J. Cell Sci. 102, 239.
      Thyberg, J., and Moskalewski, S. 1992. J. Cell Sci. 103, 1167.
      Product Information
      CAS number31430-18-9
      FormLiquid
      FormulationA 50 mM (10 mg/664 µL) solution of Nocodazole (Cat. No. 487928) in DMSO.
      Hill FormulaC₁₄H₁₁N₃O₃S
      Hygroscopic Hygroscopic
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Biological Information
      Primary TargetMicrotubules
      Secondary targetCertain kinases
      Purity≥97% by HPLC
      Physicochemical Information
      Cell permeableY
      Safety Information
      R PhraseR: 36/38

      Irritating to eyes and skin.
      S PhraseS: 26-36-45

      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Wear suitable protective clothing.
      In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
      Storage and Shipping Information
      Ship Code Dry Ice Only
      Toxicity Irritant
      Storage ≤ -70°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Avoid freeze/thaw Avoid freeze/thaw
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C). Aliquots are stable for up to 1 year at -70°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      カタログ番号 GTIN
      487929-10MGCN 04055977200393