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481407 InSolution™ NF-κB Activation Inhibitor - Calbiochem

The InSolution™ NF-κB Activation Inhibitor controls the biological activity of NF-κB. This small molecule/inhibitor is primarily used for Inflammation/Immunology applications.

InSolution™ NF-κB Activation Inhibitor - Calbiochem: のSDS（安全データシート）、CoA（試験成績書）およびCoQ（品質証明書）、カタログなど製品関連の技術資料を入手いただけます。
Primary Target: NF-κB transcriptional activation
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481407
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概要

Replacement Information

主要スペック表

Empirical Formula
C₂₂H₂₀N₄O

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481407-1MGCN
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      Description
      Catalogue Number481407
      Brand Family Calbiochem®
      References
      ReferencesTobe, M., et al. 2003. Bioorg. Med. Chem. 11, 383.
      Product Information
      ATP CompetitiveN
      FormLiquid
      FormulationA 10 mM (1 mg/281 µl) solution of NF-κB Activation Inhibitor (Cat. No. 481406) in DMSO.
      Hill FormulaC₂₂H₂₀N₄O
      Chemical formulaC₂₂H₂₀N₄O
      Hygroscopic Hygroscopic
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetNF-κB transcriptional activation
      Primary Target IC<sub>50</sub>11 nM against NF-κB transcriptional activation in Jurkat cells; 7 nM against LPS-induced TNF-α production in murine splenocytes
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped with Blue Ice or with Dry Ice
      Toxicity Toxic
      Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial use, aliquot and refrigerate (4°C).
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      カタログ番号 GTIN
      481407-1MGCN 04055977201512

      Documentation

      InSolution™ NF-κB Activation Inhibitor - Calbiochem (M)SDS

      タイトル

      英語版製品安全データシート（(M)SDS） 

      InSolution™ NF-κB Activation Inhibitor - Calbiochem 試験成績書（CoA）

      タイトルロット番号
      481407

      参考資料

      参考資料の概要
      Tobe, M., et al. 2003. Bioorg. Med. Chem. 11, 383.
      データシート

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision11-August-2008 RFH
      DescriptionA cell-permeable quinazoline compound that acts as a potent inhibitor of NF-κB transcriptional activation (IC50 = 11 nM in Jurkat cells) and LPS-induced TNF-α production (IC50 = 7 nM in murine splenocytes). Does not exhibit cellular cytotoxicity even at concentrations as high as 10 µM. Reported to exhibit anti-inflammatory effects on carregeenin-induced paw edema in rats.
      FormLiquid
      FormulationA 10 mM (1 mg/281 µl) solution of NF-κB Activation Inhibitor (Cat. No. 481406) in DMSO.
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₂₂H₂₀N₄O
      Structure formulaStructure formula
      Purity≥98% by HPLC
      Storage Protect from light
      +2°C to +8°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing initial use, aliquot and refrigerate (4°C).
      Toxicity Toxic
      ReferencesTobe, M., et al. 2003. Bioorg. Med. Chem. 11, 383.