474788 Sigma-AldrichInSolution™ MG-132 in EtOH, ≥95% by HPLC - Calbiochem
Potent, reversible, and cell-permeable proteasome inhibitor. Reduces the degradation of ubiquitin-conjugated proteins in mammalian cells and permeable stains of yeast by the 26S complex.
More>> Potent, reversible, and cell-permeable proteasome inhibitor. Reduces the degradation of ubiquitin-conjugated proteins in mammalian cells and permeable stains of yeast by the 26S complex. Less<<InSolution™ MG-132 in EtOH, ≥95% by HPLC - Calbiochem: のSDS（安全データシート）、CoA（試験成績書）およびCoQ（品質証明書）、カタログなど製品関連の技術資料を入手いただけます。
同義語: Proteasome Inhibitor XI
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概要
| Replacement Information |
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主要スペック表
| Empirical Formula |
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| C₂₆H₄₁N₃O₅ |
価格＆在庫状況
| カタログ番号 | 在庫状況 | 包装 | Qty/Pk | 価格 | 数量 | |
|---|---|---|---|---|---|---|
| 474788-10MGCN |
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ｶﾞﾗｽﾋﾞﾝ | 10 mg |
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| Description | |
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| Overview | Potent, reversible, and cell-permeable proteasome inhibitor (Ki = 4 nM). Reduces the degradation of ubiquitin-conjugated proteins in mammalian cells and permeable stains of yeast by the 26S complex without affecting its ATPase or isopeptidase activities. Activates c-Jun N-terminal kinase (JNK1) which initiates apoptosis. Inhibits NF-κB activation (IC50 = 3 µM). This material is ≥95% pure by HPLC. A material with ≥98% purity by HPLC (Cat. No. 474791) and the solid form of this compound (Cat. No. 474787) are also available. |
| Catalogue Number | 474788 |
| Brand Family | Calbiochem® |
| Synonyms | Proteasome Inhibitor XI |
| Application Data |  |
| Product Information | |
|---|---|
| Form | Liquid |
| Formulation | A 20 mM (10 mg/1.05 ml) solution of MG-132, ≥95% by HPLC (Cat. No. 474787) in EtOH. |
| Hill Formula | C₂₆H₄₁N₃O₅ |
| Chemical formula | C₂₆H₄₁N₃O₅ |
| Reversible | Y |
| Quality Level | MQ100 |
| Applications |
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| Biological Information | |
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| Primary Target K<sub>i</sub> | Ki = 4 nM for proteasomal inhibition |
| Secondary target | IKK |
| Purity | ≥95% by HPLC |
| Physicochemical Information | |
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| Cell permeable | Y |
| Peptide Sequence | Z-Leu-Leu-Leu-CHO |
| Dimensions |
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| Materials Information |
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| Toxicological Information |
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| Safety Information according to GHS |
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| Safety Information | |
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| R Phrase | R: 11-22 Highly flammable. Harmful if swallowed. |
| S Phrase | S: 16-7 Keep away from sources of ignition - No Smoking. Keep container tightly closed. |
| Product Usage Statements |
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| Packaging Information | |
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| Packaged under inert gas | Packaged under inert gas |
| Transport Information |
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| Supplemental Information |
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| Specifications |
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| Global Trade Item Number | |
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| カタログ番号 | GTIN |
| 474788-10MGCN | 04055977185461 |
Documentation
InSolution™ MG-132 in EtOH, ≥95% by HPLC - Calbiochem (M)SDS
| タイトル |
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InSolution™ MG-132 in EtOH, ≥95% by HPLC - Calbiochem 試験成績書（CoA）
| タイトル | ロット番号 |
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| 474788 |
参考資料
| 参考資料の概要 |
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| Steinhilb, M.L., et al. 2001. J. Biol. Chem. 276, 4476. Meriin, A.B., et al. 1998. J. Biol. Chem. 273, 6373. Adams, J., and Stein, R. 1996. Ann. Rep. Med. Chem. 31, 279. Klafki, H.W., et al. 1996. J. Biol. Chem. 271, 2865. Lee, D.H., and Goldberg, A.L., 1996. J. Biol. Chem. 271, 27280. Wiertz, E.J., et al. 1996. Cell 84, 769. Jensen, T.J., et al. 1995. Cell 83, 129. Read, M.A., et al. 1995. Immunity 2, 493. Rock, K.L., et al. 1994. Cell 78, 761. |
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Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
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