数量	カタログ番号	注文内容	Qty/Pk	価格
			96-Well Plate

数量	カタログ番号	注文内容	Qty/Pk	価格
	48-602MAG	Buffer Detection Kit for Magnetic Beads	1 Kit

438187 Sigma-AldrichInSolution™ Lovastatin, Sodium Salt - Calbiochem

Carboxylate form of Lovastatin that is active in whole cells and cell-free assays.

InSolution™ Lovastatin, Sodium Salt - Calbiochem: のSDS（安全データシート）、CoA（試験成績書）およびCoQ（品質証明書）、カタログなど製品関連の技術資料を入手いただけます。

(M)SDS
試験成績書（CoA）
参考資料
Data Sheet

お勧めの製品

概要

Replacement Information

主要スペック表

Empirical Formula
C₂₄H₃₇O₆ • Na

価格＆在庫状況

カタログ番号	在庫状況	包装	Qty/Pk	価格	数量
438187-5MGCN	在庫状況検索中… — 現在国内在庫なし現在国内在庫有り販売中止在庫僅少現在国内在庫あり在庫を照会するにはログインしてください現在国内在庫有り現在国内在庫なし現在国内在庫有り Remaining : Will advise Remaining : Will advise 注文対象外お問合せください Contact Customer Service お問合せくださいお問合せください	ｶﾞﾗｽﾋﾞﾝ	5 mg	価格を検索中… 価格が見つかりません Minimum Quantity needs to be mulitiple of Maximum Quantity is 弊社照会詳細を表示　値引 () — 弊社照会納入価格を閲覧するにはログインしてください	在庫状況を照会 —	お気に入り/ショッピングリストに追加お気に入り/ショッピングリストに追加お気に入りに追加されました

Description
Overview	Carboxylate form of Lovastatin (Cat. No. 438185) that is active in whole cells and cell-free assays. Lovastatin is reported to be an anti-hypercholesterolemic agent that acts as a reversible competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase and blocks a series of biological events including activation of p21^ras by insulin in 3T3-L1 fibroblasts and 3T3-L1 adipocytes, farnesylation of p21^ras, which decreases the pool of intracellular Ras available for subsequent activation by growth factors (including insulin), and N-ras-induced neuronal differentiation. Causes cell cycle arrest in the late G1 phase. Shown to inhibit the stimulation of MAP kinase by insulin in HIRcB cells and block the transcription of the type-I SCR gene in THP-1-derived macrophages. Also blocks PDGF receptor tyrosine phosphorylation and MAP kinase activation by PDGF.
Catalogue Number	438187
Brand Family	Calbiochem®

References
References	Rao, S., et al. 1999. Proc. Natl. Acad. Sci. USA 96, 7197. Carel, K., et al. 1996. J. Biol. Chem. 271, 30625. McGuire, T.F., et al. 1996. J. Biol. Chem. 271, 27402. Umetani, N., et al. 1996. Biochim. Biophys. Acta 1303, 199. Xu, X.Q., et al. 1996. Arch. Biochem. Biophys. 326, 233. Reusch, J.E.-B., et al. 1995. J. Biol. Chem. 270, 2036.

Product Information
Form	Liquid
Formulation	A 10 mM (5 mg/1.13 ml) solution of Lovastatin, Sodium Salt (Cat. No. 438186) in H₂O.
Hill Formula	C₂₄H₃₇O₆ • Na
Chemical formula	C₂₄H₃₇O₆ • Na
Reversible	Y
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Primary Target	HMG-CoA reductase
Purity	≥95% by HPLC

Physicochemical Information
Cell permeable	Y

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information
S Phrase	S: 24/25 Avoid contact with skin and eyes.

Product Usage Statements

Storage and Shipping Information
Ship Code	Dry Ice Only
Toxicity	Harmful
Storage	≤ -70°C
Protect from Light	Protect from light
Avoid freeze/thaw	Avoid freeze/thaw
Do not freeze	Ok to freeze
Special Instructions	Following initial thaw, aliquot and freeze (-70°C). Aliquots are stable for up to 6 months at -70°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
カタログ番号	GTIN
438187-5MGCN	04055977186994

Documentation

InSolution™ Lovastatin, Sodium Salt - Calbiochem (M)SDS

タイトル
英語版製品安全データシート（(M)SDS）

InSolution™ Lovastatin, Sodium Salt - Calbiochem 試験成績書（CoA）

タイトル	ロット番号
438187	ロット番号を入力

参考資料

参考資料の概要
Rao, S., et al. 1999. Proc. Natl. Acad. Sci. USA 96, 7197. Carel, K., et al. 1996. J. Biol. Chem. 271, 30625. McGuire, T.F., et al. 1996. J. Biol. Chem. 271, 27402. Umetani, N., et al. 1996. Biochim. Biophys. Acta 1303, 199. Xu, X.Q., et al. 1996. Arch. Biochem. Biophys. 326, 233. Reusch, J.E.-B., et al. 1995. J. Biol. Chem. 270, 2036.

データシート

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	11-January-2013 JSW
Description	Carboxylate form of Lovastatin (Cat. No. 438185) that is active in whole cells and cell-free assays. Lovastatin is reported to be an anti-hypercholesterolemic agent that acts as a reversible competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase and blocks a series of biological events including activation of p21^ras by insulin in 3T3-L1 fibroblasts and 3T3-L1 adipocytes, farnesylation of p21^ras, which decreases the pool of intracellular Ras available for subsequent activation by growth factors (including insulin), and N-ras-induced neuronal differentiation. Causes cell cycle arrest in the late G1 phase. Shown to inhibit the stimulation of MAP kinase by insulin in HIRcB cells and block the transcription of the type-I SCR gene in THP-1-derived macrophages. Also blocks PDGF receptor tyrosine phosphorylation and MAP kinase activation by PDGF.
Form	Liquid
Formulation	A 10 mM (5 mg/1.13 ml) solution of Lovastatin, Sodium Salt (Cat. No. 438186) in H₂O.
Intert gas (Yes/No)	Packaged under inert gas
Chemical formula	C₂₄H₃₇O₆ • Na
Structure formula
Purity	≥95% by HPLC
Storage	Protect from light Avoid freeze/thaw ≤ -70°C
Do Not Freeze	Ok to freeze
Special Instructions	Following initial thaw, aliquot and freeze (-70°C). Aliquots are stable for up to 6 months at -70°C.
Toxicity	Harmful
References	Rao, S., et al. 1999. Proc. Natl. Acad. Sci. USA 96, 7197. Carel, K., et al. 1996. J. Biol. Chem. 271, 30625. McGuire, T.F., et al. 1996. J. Biol. Chem. 271, 27402. Umetani, N., et al. 1996. Biochim. Biophys. Acta 1303, 199. Xu, X.Q., et al. 1996. Arch. Biochem. Biophys. 326, 233. Reusch, J.E.-B., et al. 1995. J. Biol. Chem. 270, 2036.

カテゴリー

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Lipid Signaling Inhibitors > HMG-CoA (3-Hydroxy-3-Methylglutaryl Coenzyme A) Reductase Inhibitors

製品がカートに追加されました