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420128 InSolution™ JNK Inhibitor II - Calbiochem

The InSolution™ JNK Inhibitor II, also referenced under CAS 129-56-6, controls the biological activity of JNK. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

InSolution™ JNK Inhibitor II - Calbiochem: のSDS（安全データシート）、CoA（試験成績書）およびCoQ（品質証明書）、カタログなど製品関連の技術資料を入手いただけます。
Primary Target: JNK 1, JNK 2, JNK 3
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420128
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概要

Replacement Information

主要スペック表

Empirical Formula
C₁₄H₈N₂O

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420128-5MGCN
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      		 樹脂ｱﾝﾌﾟﾙ 5 mg
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      Description
      Catalogue Number420128
      Brand Family Calbiochem®
      References
      ReferencesBennett, B.L., et al. 2001. Proc. Natl. Acad. Sci. USA 98, 13681.
      Han, Z., et al. 2001. J. Clin. Invest. 108, 73.
      Product Information
      ATP CompetitiveY
      FormYellowish brown liquid
      FormulationA 50 mM (5 mg/454 µl) solution of JNK Inhibitor II (Cat. No. 420119) in DMSO.
      Hill FormulaC₁₄H₈N₂O
      Chemical formulaC₁₄H₈N₂O
      Hygroscopic Hygroscopic
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetJNK 1, JNK 2, JNK 3
      Primary Target IC<sub>50</sub>40 nM for JNK-1 and JNK-2 and 90 nM for JNK-3
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Blue Ice Only
      Toxicity Irritant
      Storage -20°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial use, aliquot and refrigerate (4°C) for short-term storage or freeze (-20°C) for long-term storage.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      カタログ番号 GTIN
      420128-5MGCN 04055977188066

      Documentation

      InSolution™ JNK Inhibitor II - Calbiochem (M)SDS

      タイトル

      英語版製品安全データシート（(M)SDS） 

      InSolution™ JNK Inhibitor II - Calbiochem 試験成績書（CoA）

      タイトルロット番号
      420128

      参考資料

      参考資料の概要
      Bennett, B.L., et al. 2001. Proc. Natl. Acad. Sci. USA 98, 13681.
      Han, Z., et al. 2001. J. Clin. Invest. 108, 73.
      データシート

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision24-July-2008 RFH
      DescriptionA potent, cell-permeable, selective, and reversible inhibitor of c-Jun N-terminal kinase (JNK) (IC50 = 40 nM for JNK-1 and JNK-2 and 90 nM for JNK-3). The inhibition is competitive with respect to ATP. Exhibits over 300-fold greater selectivity for JNK as compared to ERK1 and p38-2 MAP kinases. Inhibits the phosphorylation of c-Jun and blocks the expression of IL-2, IFN-γ, TNF-α, and COX-2 in cells. Blocks IL-1-induced accumulation of phospho-Jun and induction of c-Jun transcription.
      FormYellowish brown liquid
      FormulationA 50 mM (5 mg/454 µl) solution of JNK Inhibitor II (Cat. No. 420119) in DMSO.
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₁₄H₈N₂O
      Structure formulaStructure formula
      Purity≥98% by HPLC
      Storage Protect from light
      -20°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing initial use, aliquot and refrigerate (4°C) for short-term storage or freeze (-20°C) for long-term storage.
      Toxicity Irritant
      ReferencesBennett, B.L., et al. 2001. Proc. Natl. Acad. Sci. USA 98, 13681.
      Han, Z., et al. 2001. J. Clin. Invest. 108, 73.