数量	カタログ番号	注文内容	Qty/Pk	価格
			96-Well Plate

数量	カタログ番号	注文内容	Qty/Pk	価格
	48-602MAG	Buffer Detection Kit for Magnetic Beads	1 Kit

401485 Sigma-AldrichInSolution™ IKK-2 Inhibitor, SC-514 - Calbiochem

The InSolution™ IKK-2 Inhibitor, SC-514 controls the biological activity of IKK-2. This small molecule/inhibitor is primarily used for Inflammation/Immunology applications.

InSolution™ IKK-2 Inhibitor, SC-514 - Calbiochem: のSDS（安全データシート）、CoA（試験成績書）およびCoQ（品質証明書）、カタログなど製品関連の技術資料を入手いただけます。

(M)SDS
試験成績書（CoA）
参考資料
Data Sheet

Primary Target: IKK-2

お勧めの製品

概要

Replacement Information

主要スペック表

Empirical Formula
C₉H₈N₂OS₂

価格＆在庫状況

カタログ番号	在庫状況	包装	Qty/Pk	価格	数量
401485-1MGCN	在庫状況検索中… — 現在国内在庫なし現在国内在庫有り販売中止在庫僅少現在国内在庫あり在庫を照会するにはログインしてください現在国内在庫有り現在国内在庫なし現在国内在庫有り Remaining : Will advise Remaining : Will advise 注文対象外お問合せください Contact Customer Service お問合せくださいお問合せください	樹脂ｱﾝﾌﾟﾙ	1 mg	価格を検索中… 価格が見つかりません Minimum Quantity needs to be mulitiple of Maximum Quantity is 弊社照会詳細を表示　値引 () — 弊社照会納入価格を閲覧するにはログインしてください	在庫状況を照会 —	お気に入り/ショッピングリストに追加お気に入り/ショッピングリストに追加お気に入りに追加されました

Description
Catalogue Number	401485
Brand Family	Calbiochem®

References
References	Baxter, A., et al. 2004 Bioorg. Med. Chem. Lett. 14, 2817. Kishore, N., et al. 2003. J. Biol. Chem. 278, 32861.

Product Information
ATP Competitive	Y
Form	Clear to pale yellow Liquid
Formulation	A 25 mM (1 mg/178 µl) solution of IKK-2 Inhibitor, SC-514 (Cat. No. 401479) in DMSO.
Hill Formula	C₉H₈N₂OS₂
Chemical formula	C₉H₈N₂OS₂
Hygroscopic	Hygroscopic
Reversible	Y
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Primary Target	IKK-2
Primary Target IC<sub>50</sub>	~ 3-12 µM for IKK-2 homodimer, IKK-1/IKK-2 heterodimer, and IKK-2
Purity	≥95% by HPLC

Physicochemical Information
Cell permeable	Y

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Shipped with Blue Ice or with Dry Ice
Toxicity	Irritant
Storage	+2°C to +8°C
Protect from Light	Protect from light
Hygroscopic	Hygroscopic
Do not freeze	Ok to freeze
Special Instructions	Following initial use, aliquot and refrigerate (4°C).

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
カタログ番号	GTIN
401485-1MGCN	04055977212006

Documentation

InSolution™ IKK-2 Inhibitor, SC-514 - Calbiochem (M)SDS

タイトル
英語版製品安全データシート（(M)SDS）

InSolution™ IKK-2 Inhibitor, SC-514 - Calbiochem 試験成績書（CoA）

タイトル	ロット番号
401485	ロット番号を入力

参考資料

参考資料の概要
Baxter, A., et al. 2004 Bioorg. Med. Chem. Lett. 14, 2817. Kishore, N., et al. 2003. J. Biol. Chem. 278, 32861.

データシート

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	14-July-2008 RFH
Description	A cell-permeable, potent, reversible, ATP-competitive and highly selective inhibitor of IKK-2 (IC₅₀ ~3-12 µM for IKK-2 homodimer, IKK-1/IKK-2 heterodimer, and IKK-2) that also displays anti-inflammatory properties. Specificity has been reported using a panel of 31 additional kinases, including IKK isoforms IKK-1, IKK-i, and TBK-1 (IC₅₀ >200 µM). Shown to specifically block NF-κB-dependent gene expression, but not MAP kinase pathways, in stimulated RASF synovial fibroblast cells. Does not inhibit the phosphorylation and activation of the IKK complex.
Form	Clear to pale yellow Liquid
Formulation	A 25 mM (1 mg/178 µl) solution of IKK-2 Inhibitor, SC-514 (Cat. No. 401479) in DMSO.
Intert gas (Yes/No)	Packaged under inert gas
Chemical formula	C₉H₈N₂OS₂
Structure formula
Purity	≥95% by HPLC
Storage	Protect from light +2°C to +8°C Hygroscopic
Do Not Freeze	Ok to freeze
Special Instructions	Following initial use, aliquot and refrigerate (4°C).
Toxicity	Irritant
References	Baxter, A., et al. 2004 Bioorg. Med. Chem. Lett. 14, 2817. Kishore, N., et al. 2003. J. Biol. Chem. 278, 32861.

カテゴリー

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > NF-κB Activation

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