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217721 InSolution™ Cdk1 Inhibitor IV, RO-3306 - Calbiochem

The InSolution™ Cdk1 Inhibitor IV, RO-3306 controls the biological activity of Cdk1. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

InSolution™ Cdk1 Inhibitor IV, RO-3306 - Calbiochem: のSDS（安全データシート）、CoA（試験成績書）およびCoQ（品質証明書）、カタログなど製品関連の技術資料を入手いただけます。

同義語: 5-(Quinolin-6-ylmethylene)-2-(thiophen-2-ylmethylamino)thiazol-4(5H)-one, 5-(6-Quinolinylmethylene)-2-((2-thienylmethyl)amino)-4(5H)-thiazolone

Primary Target: Cdk1/B1 and Cdk1/A
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217721
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概要

Replacement Information

主要スペック表

Empirical Formula
C₁₈H₁₃N₃OS₂

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217721-2MGCN
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      		 ｶﾞﾗｽﾋﾞﾝ 2 mg
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      Description
      OverviewA cell-permeable quinolinyl thiazolinone compound that acts as a potent and ATP-competitive inhibitor of Cdk1 (Ki = 35 nM and 110 nM for Cdk1/B1 and Cdk1/A, respectively). It affects Cdk2/E, PKCδ, and SGK only at much higher concentrations (Ki = 340, 318, and 497 nM, respectively), and shows little effect against Cdk4/D and six other commonly studied kinases (Ki =2 µM). Short-term treatment for up to 20 hrs results in fully reversible G2/M cell cycle arrest, while prolonged treament (>48 hrs) results in apoptotic cell death in proliferating cancer cells, but not in nontumorigenic epithelial cell lines. The solid form of this compound (Cat. No. 217699) is also available.
      Catalogue Number217721
      Brand Family Calbiochem®
      Synonyms5-(Quinolin-6-ylmethylene)-2-(thiophen-2-ylmethylamino)thiazol-4(5H)-one, 5-(6-Quinolinylmethylene)-2-((2-thienylmethyl)amino)-4(5H)-thiazolone
      References
      ReferencesVassilev, L.T., et al. 2006. Proc. Natl. Acad. Sci. USA 103, 10660.
      Product Information
      FormLiquid
      FormulationA 10 mM (2 mg/569 µL) solution of Cdk1 Inhibitor IV, RO-3306 (Cat. No. 217699) in DMSO.
      Hill FormulaC₁₈H₁₃N₃OS₂
      Hygroscopic Hygroscopic
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetCdk1/B1 and Cdk1/A
      Primary Target K<sub>i</sub>35 nM and 110 nM for Cdk1/B1 and Cdk1/A,
      Secondary targetCdk2/E, PKCδ, and SGK
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 36/38

      Irritating to eyes and skin.
      S PhraseS: 26-36

      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Wear suitable protective clothing.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Dry Ice Only
      Toxicity Irritant
      Storage ≤ -70°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Avoid freeze/thaw Avoid freeze/thaw
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C). Aliquots are stable for up to 6 months at -70°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      カタログ番号 GTIN
      217721-2MGCN 04055977202410

      Documentation

      InSolution™ Cdk1 Inhibitor IV, RO-3306 - Calbiochem (M)SDS

      タイトル

      英語版製品安全データシート（(M)SDS） 

      InSolution™ Cdk1 Inhibitor IV, RO-3306 - Calbiochem 試験成績書（CoA）

      タイトルロット番号
      217721

      参考資料

      参考資料の概要
      Vassilev, L.T., et al. 2006. Proc. Natl. Acad. Sci. USA 103, 10660.
      データシート

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision14-December-2012 JSW
      Synonyms5-(Quinolin-6-ylmethylene)-2-(thiophen-2-ylmethylamino)thiazol-4(5H)-one, 5-(6-Quinolinylmethylene)-2-((2-thienylmethyl)amino)-4(5H)-thiazolone
      DescriptionA cell-permeable quinolinyl thiazolinone compound that acts as a potent and ATP-competitive inhibitor of Cdk1 (Ki = 35 nM and 110 nM for Cdk1/B1 and Cdk1/A, respectively). It affects Cdk2/E, PKCδ, and SGK only at much higher concentrations (Ki = 340, 318, and 497 nM, respectively), and shows little effect against Cdk4/D and six other commonly studied kinases (Ki =2 µM). Short-term treatment for up to 20 hrs results in fully reversible G2/M cell cycle arrest, while prolonged treament (>48 hrs) results in apoptotic cell death in proliferating cancer cells, but not in nontumorigenic epithelial cell lines. The solid form of this compound (Cat. No. 217699) is also available.
      FormLiquid
      FormulationA 10 mM (2 mg/569 µL) solution of Cdk1 Inhibitor IV, RO-3306 (Cat. No. 217699) in DMSO.
      Intert gas (Yes/No) Packaged under inert gas
      Structure formulaStructure formula
      Purity≥95% by HPLC
      Storage Protect from light
      Avoid freeze/thaw
      ≤ -70°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C). Aliquots are stable for up to 6 months at -70°C.
      Toxicity Irritant
      ReferencesVassilev, L.T., et al. 2006. Proc. Natl. Acad. Sci. USA 103, 10660.