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218708 InSolution™ Casein Kinase II Inhibitor I - Calbiochem

The InSolution™ Casein Kinase II Inhibitor I controls the biological activity of Casein Kinase II. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

InSolution™ Casein Kinase II Inhibitor I - Calbiochem: のSDS（安全データシート）、CoA（試験成績書）およびCoQ（品質証明書）、カタログなど製品関連の技術資料を入手いただけます。
Primary Target: CK2 rat liver, human recombinant
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218708
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概要

Replacement Information

主要スペック表

Empirical Formula
C₆HBr₄N₃

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218708-5MGCN
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      		 樹脂ｱﾝﾌﾟﾙ 5 mg
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      Description
      Catalogue Number218708
      Brand Family Calbiochem®
      References
      ReferencesBorowski, P., et al. 2003. Eur. J. Biochem. 270, 1645.
      Zien, P., et al. 2003. Biochem. Biophys. Res. Commun. 306, 129.
      Sarno, S., et al. 2003. Biochem. J. 374, 639.
      Sarno, S., et al. 2001. FEBS Lett. 496, 44.
      Szyszka, R., et al. 1995. Biochem. Biophys. Res. Commun. 208, 418.
      Product Information
      ATP CompetitiveY
      FormLiquid
      FormulationA 10 mM (5 mg/1.15 ml) solution of Casein Kinase II Inhibitor I (Cat. No. 218697) in DMSO.
      Hill FormulaC₆HBr₄N₃
      Chemical formulaC₆HBr₄N₃
      Hygroscopic Hygroscopic
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetCK2 rat liver, human recombinant
      Primary Target IC<sub>50</sub>900 nM and 1.6 µM, using rat liver and human recombinant CK2, respectively
      PuritySingle spot by TLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped with Blue Ice or with Dry Ice
      Toxicity Carcinogenic / Teratogenic
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial use, aliquot and refrigerate (4°C).
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      カタログ番号 GTIN
      218708-5MGCN 07790788048587

      Documentation

      InSolution™ Casein Kinase II Inhibitor I - Calbiochem (M)SDS

      タイトル

      英語版製品安全データシート（(M)SDS） 

      InSolution™ Casein Kinase II Inhibitor I - Calbiochem 試験成績書（CoA）

      タイトルロット番号
      218708

      参考資料

      参考資料の概要
      Borowski, P., et al. 2003. Eur. J. Biochem. 270, 1645.
      Zien, P., et al. 2003. Biochem. Biophys. Res. Commun. 306, 129.
      Sarno, S., et al. 2003. Biochem. J. 374, 639.
      Sarno, S., et al. 2001. FEBS Lett. 496, 44.
      Szyszka, R., et al. 1995. Biochem. Biophys. Res. Commun. 208, 418."
      データシート

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision04-June-2008 RFH
      DescriptionA cell-permeable, highly selective, ATP/GTP-competitive casein kinase II (CKII) inhibitor (IC50 = 900 nM and 1.6 µM for rat liver and human recombinant CKII, respectively) and DYRK (IC50 <1 µM for DYRK1a). Specificity for CKII has been reported following the screening of 33 kinases, including PKA, Akt, PKC, MKK1, ERK2, p38, JNK, Lck, Lyn, and Syk. Also reported to inhibit NS3-associated viral helicase activity in hepatitis C virus (HCV) (IC50 = 20 and 60 µM using DNA and RNA substrates, respectively) and West Nile virus (WNV) (IC50 = 1.7 µM and 900 nM using DNA and RNA substrates, respectively).
      FormLiquid
      FormulationA 10 mM (5 mg/1.15 ml) solution of Casein Kinase II Inhibitor I (Cat. No. 218697) in DMSO.
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₆HBr₄N₃
      Structure formulaStructure formula
      PuritySingle spot by TLC
      Storage Protect from light
      +2°C to +8°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing initial use, aliquot and refrigerate (4°C).
      Toxicity Carcinogenic / Teratogenic
      ReferencesBorowski, P., et al. 2003. Eur. J. Biochem. 270, 1645.
      Zien, P., et al. 2003. Biochem. Biophys. Res. Commun. 306, 129.
      Sarno, S., et al. 2003. Biochem. J. 374, 639.
      Sarno, S., et al. 2001. FEBS Lett. 496, 44.
      Szyszka, R., et al. 1995. Biochem. Biophys. Res. Commun. 208, 418.