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124015 InSolution™ Akt Inhibitor IV - Calbiochem

The InSolution™ Akt Inhibitor IV controls the biological activity of Akt. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

InSolution™ Akt Inhibitor IV - Calbiochem: のSDS（安全データシート）、CoA（試験成績書）およびCoQ（品質証明書）、カタログなど製品関連の技術資料を入手いただけます。
Primary Target: Akt
View This Product on Sigma-Aldrich
124015
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概要

Replacement Information

主要スペック表

Empirical Formula
C₃₁H₂₇IN₄S

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      Description
      Catalogue Number124015
      Brand Family Calbiochem®
      References
      ReferencesKau, T.R., et al. 2003. Cancer Cell 4, 463.



      Selected Citations
      Lee, J., et al. 2009. Cell Stem Cell 5, 76.
      Product Information
      ATP CompetitiveN
      FormLiquid
      FormulationA 10 mM (1 mg/163 µl) solution of Akt Inhibitor IV (Cat. No. 124011) in DMSO.
      Hill FormulaC₃₁H₂₇IN₄S
      Chemical formulaC₃₁H₂₇IN₄S
      Hygroscopic Hygroscopic
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetAkt
      Primary Target IC<sub>50</sub>625 nM and <1.25 µM in blocking Akt-mediated FOXO1a nuclear export and cell proliferation, respectively, in 786-O cells
      Purity≥98% by HPLC
      Concentration Label Please refer to vial label for lot-specific concentration
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped with Blue Ice or with Dry Ice
      Toxicity Irritant
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial use, aliquot and refrigerate (4°C).
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      カタログ番号 GTIN
      124015-1MGCN 07790788047986

      Documentation

      InSolution™ Akt Inhibitor IV - Calbiochem (M)SDS

      タイトル

      英語版製品安全データシート（(M)SDS） 

      InSolution™ Akt Inhibitor IV - Calbiochem 試験成績書（CoA）

      タイトルロット番号
      124015

      参考資料

      参考資料の概要
      Kau, T.R., et al. 2003. Cancer Cell 4, 463.



      Selected Citations
      Lee, J., et al. 2009. Cell Stem Cell 5, 76.

      カタログ

      タイトル
      Akt
      Biologics 31.1
      データシート

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision09-April-2008 RFH
      DescriptionA cell-permeable benzimidazole compound that inhibits Akt phosphorylation/activation presumably by targeting the ATP binding site of a kinase upstream of Akt, but downstream of PI3K. Shown to block Akt-mediated FOXO1a nuclear export (IC50 = 625 nM) and cell proliferation (IC50 < 1.25 µM) in 786-O cells. Unlike phosphatidylinositol analog-based Akt inhibitors (Cat. Nos. 124005, 124008, 124009), this inhibitor does not affect PI3K.
      FormLiquid
      FormulationA 10 mM (1 mg/163 µl) solution of Akt Inhibitor IV (Cat. No. 124011) in DMSO.
      Intert gas (Yes/No) Packaged under inert gas
      Concentration Label Please refer to vial label for lot-specific concentration
      Chemical formulaC₃₁H₂₇IN₄S
      Structure formulaStructure formula
      Purity≥98% by HPLC
      Storage Protect from light
      +2°C to +8°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing initial use, aliquot and refrigerate (4°C).
      Toxicity Irritant
      ReferencesKau, T.R., et al. 2003. Cancer Cell 4, 463.



      Selected Citations
      Lee, J., et al. 2009. Cell Stem Cell 5, 76.