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171261 InSolution™ AMPK Inhibitor, Compound C - CAS 866405-64-3 - Calbiochem

InSolution™ AMPK Inhibitor, Compound C, CAS 866405-64-3, is a 10 mM (1 mg/250 µl) solution of AMPK Inhibitor, Compound C (Cat. No. 171260) in DMSO.

InSolution™ AMPK Inhibitor, Compound C - CAS 866405-64-3 - Calbiochem: のSDS（安全データシート）、CoA（試験成績書）およびCoQ（品質証明書）、カタログなど製品関連の技術資料を入手いただけます。

同義語: Dorsomorphin, BMP Inhibitor I, AMPK Inhibitor I

Primary Target: AMPK
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171261
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概要

主要スペック表

CAS #Empirical Formula
866405-64-3C₂₄H₂₅N₅O

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      Description
      OverviewA cell-permeable pyrrazolopyrimidine compound that inhibits against KDR/VEGFR2, ALK2/BMPR-I, AMPK kinase activity (IC50 = 25.1, 148, and 234.6 nM, respectively), while exhibiting much reduced or little effect toward ALK5/TGFβR-I, ZAPK, Syk, PKCθ, PKA, or JAK3. Shown to block both BMP pathway-dependent dorsoventral development (EC100 = 2.5 µM) and VEGF signaling-dependent intersomitic vessel formation (EC50 = 5 µM) in zebrafish embryo in vivo. Commonly used in combination with AMPK activators AICAR (Cat. No. 123040) and/or Metformin (Cat. No. 317240) for studying AMPK-dependent cellular events in vitro and physiological responses in animals in vivo.
      Catalogue Number171261
      Brand Family Calbiochem®
      SynonymsDorsomorphin, BMP Inhibitor I, AMPK Inhibitor I
      References
      ReferencesHao, J., et al. 2010. ACS Chem.Biol. 5, 245.
      Kim, E.K., et al. 2004. J. Biol. Chem. 279, 19970.
      Lee, M., et al. 2003. J. Biol. Chem. 278, 39653.
      Inoki, K., et al. 2003. Cell 115, 577.
      Fryer, L.G., 2002. FEBS Lett. 531, 189.
      Zhou, G., et al. 2001. J. Clin. Invest. 108, 1167.
      Product Information
      CAS number866405-64-3
      ATP CompetitiveY
      FormLiquid
      FormulationSupplied as a 10 mM (1 mg/250 µl) solution of AMPK Inhibitor, Compound C (Cat. No. 171260) in DMSO.
      Hill FormulaC₂₄H₂₅N₅O
      Chemical formulaC₂₄H₂₅N₅O
      Hygroscopic Hygroscopic
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Biological Information
      Primary TargetAMPK
      Primary Target IC<sub>50</sub>25.1, 148, and 234.6 nM, against KDR/VEGFR2, ALK2/BMPR-I, AMPK kinase activity, respectively
      Primary Target K<sub>i</sub>EC100 = 2.5 µM against BMP pathway-dependent dorsoventral development; EC50 = 5 µM against VEGF signaling-dependent intersomitic vessel formation in zebrafish embryo in vivo
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Storage and Shipping Information
      Ship Code Shipped with Blue Ice or with Dry Ice
      Toxicity Irritant
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial use, aliquot and freeze (-20°C). Once opened, stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      カタログ番号 GTIN
      171261-1MGCN 04055977207170