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407616 IL-1R Antagonist - CAS 566914-00-9 - Calbiochem

IL-1R Antagonist, CAS 566914-00-9, is a cell-permeable, end protected L-valyl derivative. Specifically blocks TIR domain-mediated MyD88/IL1-RI interaction without affecting TLR4/MyD88 interaction.

IL-1R Antagonist - CAS 566914-00-9 - Calbiochem: のSDS（安全データシート）、CoA（試験成績書）およびCoQ（品質証明書）、カタログなど製品関連の技術資料を入手いただけます。

同義語: BB-loop Mimic, Hydrocinnamoyl-L-valyl Pyrrolidine, TIR Domain Mimic

Primary Target: TIR domain-mediated MyD88/IL1-RI interaction
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407616
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概要

Replacement Information

主要スペック表

CAS #Empirical Formula
566914-00-9C₁₈H₂₆N₂O₂

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カタログ番号 在庫状況包装 Qty/Pk 価格 数量
407616-10MGCN
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      		 樹脂ｱﾝﾌﾟﾙ 10 mg
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      407616-25MGCN
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          		 樹脂ｱﾝﾌﾟﾙ 25 mg
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          Description
          OverviewA cell-permeable, end protected L-valyl derivative modeled on the MyD88-binding sequence of the TIR (Toll/IL-1R/resistance) domain BB-loop of IL-1RI (type I IL-1 receptor). It specifically inhibits TIR domain-mediated MyD88/IL1-RI interaction without affecting TLR4/MyD88 interaction. It was used successfully to reduce IL-1β-induced fever in mice in vivo and to attenuate IL-1β-induced, but not LPS-induced, activation of MAP kinase signaling cascades in murine lymphocytes and EL4 thymoma cells in vitro.
          Catalogue Number407616
          Brand Family Calbiochem®
          SynonymsBB-loop Mimic, Hydrocinnamoyl-L-valyl Pyrrolidine, TIR Domain Mimic
          References
          ReferencesBartfai, T., et al. 2003. Proc. Natl. Acad. Sci. USA 100, 7971.
          Product Information
          CAS number566914-00-9
          ATP CompetitiveN
          FormColorless oil
          Hill FormulaC₁₈H₂₆N₂O₂
          Chemical formulaC₁₈H₂₆N₂O₂
          ReversibleN
          Structure formula ImageStructure formula Image
          Quality LevelMQ100
          Applications
          ApplicationIL-1R Antagonist, CAS 566914-00-9, is a cell-permeable, end protected L-valyl derivative. Specifically blocks TIR domain-mediated MyD88/IL1-RI interaction without affecting TLR4/MyD88 interaction.
          Biological Information
          Primary TargetTIR domain-mediated MyD88/IL1-RI interaction
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications
          Global Trade Item Number
          カタログ番号 GTIN
          407616-10MGCN 04055977211337
          407616-25MGCN 04055977211344

          Documentation

          IL-1R Antagonist - CAS 566914-00-9 - Calbiochem (M)SDS

          タイトル

          英語版製品安全データシート（(M)SDS） 

          IL-1R Antagonist - CAS 566914-00-9 - Calbiochem 試験成績書（CoA）

          タイトルロット番号
          407616

          参考資料

          参考資料の概要
          Bartfai, T., et al. 2003. Proc. Natl. Acad. Sci. USA 100, 7971.
          データシート

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision14-July-2008 RFH
          SynonymsBB-loop Mimic, Hydrocinnamoyl-L-valyl Pyrrolidine, TIR Domain Mimic
          DescriptionA cell-permeable, end protected L-valyl derivative of the MyD88-binding sequence of the TIR (Toll/IL-1R/resistance) domain BB-loop of IL-1RI (type I IL-1 receptor). It specifically inhibits TIR domain-mediated MyD88/IL1-RI interaction without affecting TLR4/MyD88 interaction. It was used successfully to reduce IL-1β-induced fever in mice in vivo and to attenuate IL-1β-induced, but not LPS-induced, activation of MAP kinase signaling cascades in murine lymphocytes and EL4 thymoma cells in vitro.
          FormColorless oil
          Intert gas (Yes/No) Packaged under inert gas
          CAS number566914-00-9
          Chemical formulaC₁₈H₂₆N₂O₂
          Structure formulaStructure formula
          Purity≥95% by HPLC
          SolubilityDMSO (10 mg/ml) or Ethanol
          Storage +2°C to +8°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesBartfai, T., et al. 2003. Proc. Natl. Acad. Sci. USA 100, 7971.