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CC077 Human Collagen Type V

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CC077
100 µg  
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      概要

      Replacement Information

      主要スペック表

      Key Applications
      CULT
      Description
      Catalogue NumberCC077
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionHuman Collagen Type V
      OverviewPROPERTIES:

      Molecular composition: [alpha1(V)]2 alpha2(V), native triple helix.

      Purity and retention of native helical structure was monitored by SDS-PAGE, ORD measurement, and by reaction with anti-collagen type-specific monoclonal antibodies.
      References
      Product Information
      PresentationLiquid, in 0.1M acetic acid, pH 3.0. No preservatives added.
      Quality LevelMQ100
      Applications
      Key Applications
      • Cell Culture
      Biological Information
      Concentration1 mg/ml
      Purity95% by SDS-PAGE

      Contaminants: <2% collagen type I, <1% collagen type III, <2% collagen type IV and <0.5% non-collagen proteins.

      PURIFICATION:

      Purified by serial salt precipitations of a pepsin extraction of human fetal membranes and chromatography on DEAE-cellulose.
      SourceHuman placenta, negative for HBsAG and HIV antibodies.
      Entrez Gene Number
      Entrez Gene SummaryThis gene encodes an alpha chain for one of the low abundance fibrillar collagens. Fibrillar collagen molecules are trimers that can be composed of one or more types of alpha chains. Type V collagen is found in tissues containing type I collagen and appears to regulate the assembly of heterotypic fibers composed of both type I and type V collagen. This gene product is closely related to type XI collagen and it is possible that the collagen chains of types V and XI constitute a single collagen type with tissue-specific chain combinations. Mutations in this gene are associated with Ehlers-Danlos syndrome, types I and II.
      Gene Symbol
      • COL5A1
      • OTTHUMP00000064637
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P20908 # Type V collagen is a member of group I collagen (fibrillar forming collagen). It is a minor connective tissue component of nearly ubiquitous distribution. Type V collagen binds to DNA, heparan sulfate, thrombospondin, heparin, and insulin.
      SIZE: 1838 amino acids; 183560 Da
      SUBUNIT: Trimers of two alpha 1(V) and one alpha 2(V) chains in most tissues and trimers of one alpha 1(V), one alpha 2(V), and one alpha 3(V) chains in placenta. Interacts with CSPG4.
      SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix (By similarity).
      PTM: Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains. & Sulfated on 40% of tyrosines.
      DISEASE: SwissProt: P20908 # Defects in COL5A1 are a cause of Ehlers-Danlos syndrome type I (EDS-I) [MIM:130000]; also known as Ehlers-Danlos syndrome gravis. EDS-I is a connective-tissue disorder characterized by loose-jointedness and fragile, velvety, stretchable, bruisable skin that heals with peculiar 'cigarette-paper' scars. Inheritance is autosomal dominant. & Defects in COL5A1 are a cause of Ehlers-Danlos syndrome type II (EDS-II) [MIM:130010]; also known as Ehlers-Danlos syndrome mitis. Inheritance is autosomal dominant.
      SIMILARITY: SwissProt: P20908 ## Belongs to the fibrillar collagen family. & Contains 1 laminin G-like domain. & Contains 1 TSP N-terminal (TSPN) domain.
      Stem Cell Type
      • Human Embryonic Stem Cells
      • Mesenchymal Stem Cells
      • Neural Stem Cells
      • Hematopoietic Stem Cells
      • Epithelial Cells
      • Pancreatic Stem Cells
      • Induced Pluripotent Stem Cells
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain at -20°C in undiluted aliquots for up to 12 months. Do not thaw and refreeze.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      カタログ番号 GTIN
      CC077 04053252327070

      Documentation

      Human Collagen Type V (M)SDS

      タイトル

      英語版製品安全データシート((M)SDS) 

      Human Collagen Type V 試験成績書(CoA)

      タイトルロット番号
      PURIFIED HUMAN COLLAGEN TYPE V 3162492
      PURIFIED HUMAN COLLAGEN TYPE V 2929352
      PURIFIED HUMAN COLLAGEN TYPE V 2458996
      PURIFIED HUMAN COLLAGEN TYPE V - 2344718 2344718
      PURIFIED HUMAN COLLAGEN TYPE V - 1999442 1999442
      PURIFIED HUMAN COLLAGEN TYPE V - 2020833 2020833
      PURIFIED HUMAN COLLAGEN TYPE V - 2054786 2054786
      PURIFIED HUMAN COLLAGEN TYPE V - 2279505 2279505
      PURIFIED HUMAN COLLAGEN TYPE V - 3050807 3050807
      PURIFIED HUMAN COLLAGEN TYPE V - 3162488 3162488

      参考資料

      参考資料の概要Pub Med ID
      The effects of tissue pretreatment and pepsin levels on the isolation of collagens from human placenta.
      Klasson, S C, et al.
      Coll. Relat. Res., 6: 397-408 (1986)  1986

      概要を表示する
      3102159 3102159
      Characterization of a novel collagen chain in human placenta and its relation to AB collagen.
      Sage, H and Bornstein, P
      Biochemistry, 18: 3815-22 (1979)  1979

      概要を表示する
      224919 224919
      Isolation and characterization of a native placental basement-membrane collagen and its component alpha chains.
      Glanville, R W, et al.
      Eur. J. Biochem., 95: 383-9 (1979)  1979

      概要を表示する
      456357 456357

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      Life Science Research > タンパク質と酵素 > ECM Proteins for Plate Coating