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382111 Histone Acetyltransferase Inhibitor IV, CPTH2 - CAS 357649-93-5 - Calbiochem

Histone Acetyltransferase Inhibitor IV, CPTH2 - CAS 357649-93-5 - Calbiochem: のSDS（安全データシート）、CoA（試験成績書）およびCoQ（品質証明書）、カタログなど製品関連の技術資料を入手いただけます。

同義語: HAT Inhibitor IV, Cyclopentylidene-(4-(4ʹ-chlorophenyl)thiazol-2-yl)hydrazone, GCN5 Inhibitor II, N-acetyltransferase 10 Inhibitor I, NAT10 Inhibitor I

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382111
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概要

Replacement Information

主要スペック表

CAS #Empirical Formula
357649-93-5C₁₄H₁₄ClN₃S

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382111-10MGCN
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      		 10 mg
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      Description
      OverviewA cell-permeable thiazolyl-hydrazone compound that inhibits the acetylation of histone H3 by recombinant human Gcn5 in a substrate-competive manner, while exhibiting little activity against rhGcn5 autoacetylation. Although functional knockout of Gcn5 in Saccharomyces cerevisiae by genetic deletion or by CPTH2 treatment is not detrimental to the survival of the budding yeast, CPTH2 treatment is shown to inhibit the growth of yeast strain genetically deleted of Gcn5, but not strains deleted of Elp3 or Sas2.
      Catalogue Number382111
      Brand Family Calbiochem®
      SynonymsHAT Inhibitor IV, Cyclopentylidene-(4-(4ʹ-chlorophenyl)thiazol-2-yl)hydrazone, GCN5 Inhibitor II, N-acetyltransferase 10 Inhibitor I, NAT10 Inhibitor I
      References
      ReferencesLarrieu, D., et al. 2014. Science, 344, 527.
      Chimenti, F., et al. 2009. J. Med. Chem. 52, 530.
      Product Information
      CAS number357649-93-5
      FormBrown solid
      Hill FormulaC₁₄H₁₄ClN₃S
      Chemical formulaC₁₄H₁₄ClN₃S
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥95% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      カタログ番号 GTIN
      382111-10MGCN 04055977213102

      Documentation

      Histone Acetyltransferase Inhibitor IV, CPTH2 - CAS 357649-93-5 - Calbiochem (M)SDS

      タイトル

      英語版製品安全データシート（(M)SDS） 

      Histone Acetyltransferase Inhibitor IV, CPTH2 - CAS 357649-93-5 - Calbiochem 試験成績書（CoA）

      タイトルロット番号
      382111

      参考資料

      参考資料の概要
      Larrieu, D., et al. 2014. Science, 344, 527.
      Chimenti, F., et al. 2009. J. Med. Chem. 52, 530.

      技術情報

      タイトル
      White Paper - The Message in the Marks: Deciphering Cancer Epigenetics
      データシート

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision08-February-2011 RFH
      SynonymsHAT Inhibitor IV, Cyclopentylidene-(4-(4ʹ-chlorophenyl)thiazol-2-yl)hydrazone, GCN5 Inhibitor II, N-acetyltransferase 10 Inhibitor I, NAT10 Inhibitor I
      DescriptionA cell-permeable thiazolyl-hydrazone compound that inhibits the acetylation of histone H3 by recombinant human Gcn5 in a substrate-competive manner, while exhibiting little activity against rhGcn5 autoacetylation. Although functional knockout of Gcn5 in Saccharomyces cerevisiae by genetic deletion or by CPTH2 treatment is not detrimental to the survival of the budding yeast, CPTH2 treatment is shown to inhibit the growth of yeast strain genetically deleted of Gcn5, but not strains deleted of Elp3 or Sas2.
      FormBrown solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number357649-93-5
      Chemical formulaC₁₄H₁₄ClN₃S
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (50 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesLarrieu, D., et al. 2014. Science, 344, 527.
      Chimenti, F., et al. 2009. J. Med. Chem. 52, 530.