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376816 Hexokinase II VDAC Binding Domain Peptide, Cell-Permeable - Calbiochem

A cell-permeable peptide analog of Hexokinase II VDAC binding domain peptide.

Hexokinase II VDAC Binding Domain Peptide, Cell-Permeable - Calbiochem: のSDS（安全データシート）、CoA（試験成績書）およびCoQ（品質証明書）、カタログなど製品関連の技術資料を入手いただけます。

同義語: HXK2VBD-cpm, H-RQIKIWFQNRRMKWKK-MIASHLLAYFFTELN-NH₂

Primary Target: Detach and translocate HXK2 from mitochondria to the cytosol
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376816
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概要

Replacement Information

主要スペック表

Empirical Formula
C₁₈₈H₂₉₁N₅₃O₄₀S₂

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376816-1MGCN
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      Description
      OverviewA cell-permeable peptide analog of Hexokinase II VDAC binding domain peptide (Cat. No. 376815). The internalization domain of the Antennapedia homeoprotein is fused to the methionine amino terminal. Shown to completely detach and translocate HXK2 from mitochondria to the cytosol in HeLa cells at 100 µM. Does not induce Bax translocation or cytochrome c release when used alone. However, it markedly sensitizes cells to cytochrome c release and to the induction of apoptosis when used in combination with a Bax-dependent apoptosis inducer, Indomethacin (Cat. No. 405268).
      Catalogue Number376816
      Brand Family Calbiochem®
      SynonymsHXK2VBD-cpm, H-RQIKIWFQNRRMKWKK-MIASHLLAYFFTELN-NH₂
      References
      ReferencesPastorino, J.G., et al. 2002. J. Biol. Chem. 277, 7610.
      Holinger, E.P., et al. 1999. J. Biol. Chem. 274, 13298.
      Sui, D., and Wilson, J.E. 1997. Arch. Biochem. Biophys. 345, 111.
      Product Information
      ATP CompetitiveN
      FormWhite lyophilized solid
      FormulationSupplied as a trifluoroacetate salt.
      Hill FormulaC₁₈₈H₂₉₁N₅₃O₄₀S₂
      Chemical formulaC₁₈₈H₂₉₁N₅₃O₄₀S₂
      Hygroscopic Hygroscopic
      ReversibleN
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetDetach and translocate HXK2 from mitochondria to the cytosol
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Peptide SequenceH-Arg-Gln-Ile-Lys-Ile-Trp-Phe-Gln-Asn-Arg-Arg-Met-Lys-Trp-Lys-Lys-Met-Ile-Ala-Ser-His-Leu-Leu-Ala-Tyr-Phe-Phe-Thr-Glu-Leu-Asn-NH₂
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Blue Ice Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      カタログ番号 GTIN
      376816-1MGCN 04055977212976

      Documentation

      Hexokinase II VDAC Binding Domain Peptide, Cell-Permeable - Calbiochem (M)SDS

      タイトル

      英語版製品安全データシート（(M)SDS） 

      Hexokinase II VDAC Binding Domain Peptide, Cell-Permeable - Calbiochem 試験成績書（CoA）

      タイトルロット番号
      376816

      参考資料

      参考資料の概要
      Pastorino, J.G., et al. 2002. J. Biol. Chem. 277, 7610.
      Holinger, E.P., et al. 1999. J. Biol. Chem. 274, 13298.
      Sui, D., and Wilson, J.E. 1997. Arch. Biochem. Biophys. 345, 111.
      データシート

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision09-July-2008 RFH
      SynonymsHXK2VBD-cpm, H-RQIKIWFQNRRMKWKK-MIASHLLAYFFTELN-NH₂
      DescriptionA cell-permeable peptide analog of Hexokinase II VDAC binding domain (HXK2VBD) peptide (Cat. No. 376815). The internalization sequence of the Antennapedia homeoprotein is fused to the N-terminal methionine of the HXK2VBD peptide. Has been shown to cause the complete release of hexokinase II (HXK2) from the mitochondria and subsequent translocation to the cytosol in HeLa cells (100% release at 100 µM). Does not induce Bax translocation or cytochrome c release. Also shown to markedly sensitize cells to Bax-induced cytochrome c release. Also increases the sensitivity of cells to apoptosis in combination with the Bax-dependent apoptosis inducer, Indomethicin (Cat. No. 405268).
      FormWhite lyophilized solid
      FormulationSupplied as a trifluoroacetate salt.
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₁₈₈H₂₉₁N₅₃O₄₀S₂
      Peptide SequenceH-Arg-Gln-Ile-Lys-Ile-Trp-Phe-Gln-Asn-Arg-Arg-Met-Lys-Trp-Lys-Lys-Met-Ile-Ala-Ser-His-Leu-Leu-Ala-Tyr-Phe-Phe-Thr-Glu-Leu-Asn-NH₂
      Purity≥95% by HPLC
      SolubilityH₂O (1 mg/ml)
      Storage Protect from light
      -20°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesPastorino, J.G., et al. 2002. J. Biol. Chem. 277, 7610.
      Holinger, E.P., et al. 1999. J. Biol. Chem. 274, 13298.
      Sui, D., and Wilson, J.E. 1997. Arch. Biochem. Biophys. 345, 111.