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373260 Heat Shock Protein Inhibitor I - CAS 218924-25-5 - Calbiochem

Heat Shock Protein Inhibitor I, CAS 218924-25-5 blocks the induction of HSP70, HSP72, and HSP105. Blocks the development of thermotolerance in a dose-dependent manner.

Heat Shock Protein Inhibitor I - CAS 218924-25-5 - Calbiochem: のSDS（安全データシート）、CoA（試験成績書）およびCoQ（品質証明書）、カタログなど製品関連の技術資料を入手いただけます。

同義語: KNK437, N-Formyl-3,4-methylenedioxy-benzylidine-γ-butyrolactam, Hsp70 Induction Inhibitor I

Primary Target: Hsp70
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373260
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概要

Replacement Information

主要スペック表

CAS #Empirical Formula
218924-25-5C₁₃H₁₁NO₄

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      		 ｶﾞﾗｽﾋﾞﾝ 5 mg
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      Description
      OverviewA benzylidene lactam compound that blocks the induction of heat shock proteins HSP70, HSP72, and HSP105. Blocks the development of thermotolerance in a dose-dependent manner. Does not affect the thermosensitivity of nontolerant cells. Reported to be less toxic and more effective than Quercetin (Cat. No. 551600); and unlike Quercetin, it does not have an affect on the activities of PKA, PKC, or PTK.
      Catalogue Number373260
      Brand Family Calbiochem®
      SynonymsKNK437, N-Formyl-3,4-methylenedioxy-benzylidine-γ-butyrolactam, Hsp70 Induction Inhibitor I
      References
      ReferencesKoishi, M., et al. 2001. Clin. Cancer Res. 7, 215.
      Yokota, S., et al. 2000. Cancer Res. 60, 2942.
      Product Information
      CAS number218924-25-5
      ATP CompetitiveN
      FormWhite to light yellow powder
      Hill FormulaC₁₃H₁₁NO₄
      Chemical formulaC₁₃H₁₁NO₄
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetHsp70
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 20/21/22

      Harmful by inhalation, in contact with skin and if swallowed.
      S PhraseS: 36

      Wear suitable protective clothing.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Harmful
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 6 weeks at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      カタログ番号 GTIN
      373260-5MGCN 04055977191004

      Documentation

      Heat Shock Protein Inhibitor I - CAS 218924-25-5 - Calbiochem (M)SDS

      タイトル

      英語版製品安全データシート（(M)SDS） 

      Heat Shock Protein Inhibitor I - CAS 218924-25-5 - Calbiochem 試験成績書（CoA）

      タイトルロット番号
      373260

      参考資料

      参考資料の概要
      Koishi, M., et al. 2001. Clin. Cancer Res. 7, 215.
      Yokota, S., et al. 2000. Cancer Res. 60, 2942.
      データシート

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision12-April-2011 RFH
      SynonymsKNK437, N-Formyl-3,4-methylenedioxy-benzylidine-γ-butyrolactam, Hsp70 Induction Inhibitor I
      DescriptionA benzylidine lactam compound that inhibits the induction of heat shock proteins, including HSP70, HSP72, and HSP105. Blocks the development of thermotolerance in a dose-dependent manner, but does not affect the thermosensitivity of nontolerant cells. Reported to be less toxic and more effective than Quercetin (Cat. No. 551600), and, unlike quercetin, it does not affect the activities of PKA, PKC, and PTK.
      FormWhite to light yellow powder
      Intert gas (Yes/No) Packaged under inert gas
      CAS number218924-25-5
      Chemical formulaC₁₃H₁₁NO₄
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (3 mg/ml) or Olive oil
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 6 weeks at -20°C.
      Toxicity Harmful
      ReferencesKoishi, M., et al. 2001. Clin. Cancer Res. 7, 215.
      Yokota, S., et al. 2000. Cancer Res. 60, 2942.