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400083 HIF-1 Inhibitor - CAS 934593-90-5 - Calbiochem

The HIF-1 Inhibitor, also referenced under CAS 934593-90-5, controls the biological activity of HIF-1.

HIF-1 Inhibitor - CAS 934593-90-5 - Calbiochem: のSDS（安全データシート）、CoA（試験成績書）およびCoQ（品質証明書）、カタログなど製品関連の技術資料を入手いただけます。

同義語: CAY10585, 3-(2-(4-Adamantan-1-yl-phenoxy)-acetylamino)-4-hydroxybenzoic acid methyl ester, Hypoxia-Inducible Factor-1 Inhibitor, LW6

400083
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概要

Replacement Information

主要スペック表

CAS #Empirical Formula
934593-90-5C₂₆H₂₉NO₅

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400083-10MGCN
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      		 ｶﾞﾗｽﾋﾞﾝ 10 mg
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      Description
      OverviewA cell-permeable amidophenolic compound that inhibits hypoxia-induced HIF-1 transcription activity (IC50 = 0.7 and 2.6 µM using AGS and Hep3B cells, respectively, in a reporter assay) by selectively blocking the hypoxia-induced accumulation of cellular HIF-1α protein, while exhibiting no apparent effect on the cellular level of HIF-1α mRNA or that of HIF-1β protein. Shown to inhibit malate dehydrogenase 2 (MDH2) activity and suppress mitochondrial respiration. Also available as a 25 mM solution in DMSO (Cat. No. 400092).
      Catalogue Number400083
      Brand Family Calbiochem®
      SynonymsCAY10585, 3-(2-(4-Adamantan-1-yl-phenoxy)-acetylamino)-4-hydroxybenzoic acid methyl ester, Hypoxia-Inducible Factor-1 Inhibitor, LW6
      References
      ReferencesLee, K., et al., 2013. Angew. Chem. Int. Ed. 52, In press.
      Lee, K. et. al. 2010. Biochem. Pharmacol. 80, 982.
      Lee, K., et al. 2007. J. Med. Chem. 50, 1675.
      Product Information
      CAS number934593-90-5
      FormLight beige powder
      Hill FormulaC₂₆H₂₉NO₅
      Chemical formulaC₂₆H₂₉NO₅
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥98% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      カタログ番号 GTIN
      400083-10MGCN 07790788049980

      Documentation

      HIF-1 Inhibitor - CAS 934593-90-5 - Calbiochem 試験成績書（CoA）

      タイトルロット番号
      400083

      参考資料

      参考資料の概要
      Lee, K., et al., 2013. Angew. Chem. Int. Ed. 52, In press.
      Lee, K. et. al. 2010. Biochem. Pharmacol. 80, 982.
      Lee, K., et al. 2007. J. Med. Chem. 50, 1675.
      データシート

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision11-December-2013 JSW
      SynonymsCAY10585, 3-(2-(4-Adamantan-1-yl-phenoxy)-acetylamino)-4-hydroxybenzoic acid methyl ester, Hypoxia-Inducible Factor-1 Inhibitor, LW6
      DescriptionA cell-permeable amidophenolic compound that inhibits hypoxia-induced HIF-1 transcription activity (IC50 = 0.7 and 2.6 µM using AGS and Hep3B cells, respectively, in a reporter assay) by selectively blocking the hypoxia-induced accumulation of cellular HIF-1α protein, while exhibiting no apparent effect on the cellular level of HIF-1α mRNA or that of HIF-1β protein.
      FormLight beige powder
      Intert gas (Yes/No) Packaged under inert gas
      CAS number934593-90-5
      Chemical formulaC₂₆H₂₉NO₅
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (10 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesLee, K., et al., 2013. Angew. Chem. Int. Ed. 52, In press.
      Lee, K. et. al. 2010. Biochem. Pharmacol. 80, 982.
      Lee, K., et al. 2007. J. Med. Chem. 50, 1675.