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370677 Guanosine 3ʹ,5ʹ-cyclic Monophosphorothioate, 8-(4-Chlorophenylthio)-, Rp-Isomer, Triethylammonium Salt - Calbiochem

A potent, cell-permeable, and metabolically-stable inhibitor of protein kinase G Iα, Iβ, and type II.

Guanosine 3ʹ,5ʹ-cyclic Monophosphorothioate, 8-(4-Chlorophenylthio)-, Rp-Isomer, Triethylammonium Salt - Calbiochem: のSDS（安全データシート）、CoA（試験成績書）およびCoQ（品質証明書）、カタログなど製品関連の技術資料を入手いただけます。

同義語: Rp-8-pCPT-cGMPS, TEA, PKG Inhibitor III

Primary Target: PKG1α
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370677
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概要

Replacement Information

主要スペック表

Empirical Formula
C₁₆H₁₅ClN₅O₆PS₂ · C₆H₁₅N

価格＆在庫状況

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370677-1UMOLCN
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      		 樹脂ｱﾝﾌﾟﾙ 1 umol
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      Description
      OverviewA potent, cell-permeable, and metabolically-stable inhibitor of protein kinase G Iα, Iβ, and type II. Significantly more lipophilic and membrane-permeable than Rp-cGMPS or Rp-8-Br-cGMPS (Cat. No. 370674). Note: 1 µmol = 0.61 mg.
      Catalogue Number370677
      Brand Family Calbiochem®
      SynonymsRp-8-pCPT-cGMPS, TEA, PKG Inhibitor III
      References
      ReferencesAbd Alla, S., et al. 1996. Eur. J. Biochem. 241, 498.
      Lee, S.J., et al. 1996. Dev. Biol. 180, 324.
      Van Uffelen, B.E., et al. 1996. J. Leukoc. Biol. 60, 94.
      Willmott, N., et al. 1996. J. Biol. Chem. 271, 3699.
      Butt, E., et al. 1994. Eur. J. Pharmacol. 269, 265.
      Product Information
      ATP CompetitiveN
      DeclarationSold under license of U.S. Patent 5,625,056, Patents DE 3,802,865.4, and DE 4,217,679 issued to BIOLOG LSI.
      FormLyophilized
      Hill FormulaC₁₆H₁₅ClN₅O₆PS₂ · C₆H₁₅N
      Chemical formulaC₁₆H₁₅ClN₅O₆PS₂ · C₆H₁₅N
      Hygroscopic Hygroscopic
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetPKG1α
      Purity≥99% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      カタログ番号 GTIN
      370677-1UMOLCN 04055977191707

      Documentation

      Guanosine 3ʹ,5ʹ-cyclic Monophosphorothioate, 8-(4-Chlorophenylthio)-, Rp-Isomer, Triethylammonium Salt - Calbiochem (M)SDS

      タイトル

      英語版製品安全データシート（(M)SDS） 

      Guanosine 3ʹ,5ʹ-cyclic Monophosphorothioate, 8-(4-Chlorophenylthio)-, Rp-Isomer, Triethylammonium Salt - Calbiochem 試験成績書（CoA）

      タイトルロット番号
      370677

      参考資料

      参考資料の概要
      Abd Alla, S., et al. 1996. Eur. J. Biochem. 241, 498.
      Lee, S.J., et al. 1996. Dev. Biol. 180, 324.
      Van Uffelen, B.E., et al. 1996. J. Leukoc. Biol. 60, 94.
      Willmott, N., et al. 1996. J. Biol. Chem. 271, 3699.
      Butt, E., et al. 1994. Eur. J. Pharmacol. 269, 265.
      データシート

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision07-July-2008 RFH
      SynonymsRp-8-pCPT-cGMPS, TEA, PKG Inhibitor III
      DescriptionA potent, cell-permeable inhibitor of protein kinase G Iα, Iβ, and type II. A combination of the protein kinase inhibitor Rp-cGMPS and the widely used cGMP analog, 8-pCPT-cGMP. Significantly more lipophilic and membrane-permeant than Rp-cGMPS and Rp-8-Br-cGMPS. Resistant to hydrolysis by mammalian cyclic nucleotide dependent phosphodiesterases. Note: 1 µmol = 0.61 mg.
      FormLyophilized
      Chemical formulaC₁₆H₁₅ClN₅O₆PS₂ · C₆H₁₅N
      Structure formulaStructure formula
      Purity≥99% by HPLC
      SolubilityDMSO or H₂O (0.5 mg/ml)
      Storage -20°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesAbd Alla, S., et al. 1996. Eur. J. Biochem. 241, 498.
      Lee, S.J., et al. 1996. Dev. Biol. 180, 324.
      Van Uffelen, B.E., et al. 1996. J. Leukoc. Biol. 60, 94.
      Willmott, N., et al. 1996. J. Biol. Chem. 271, 3699.
      Butt, E., et al. 1994. Eur. J. Pharmacol. 269, 265.