数量	カタログ番号	注文内容	Qty/Pk	価格
			96-Well Plate

数量	カタログ番号	注文内容	Qty/Pk	価格
	48-602MAG	Buffer Detection Kit for Magnetic Beads	1 Kit

530030 Sigma-AldrichGlutaminase Inhibitor II, BPTES - CAS 314045-39-1 - Calbiochem

A cell-permeable, potent, selective, reversible, and uncompetitive allosteric inhibitor of kidney-type glutaminase (GLS1). Does not affect the activity of liver glutaminase.

Glutaminase Inhibitor II, BPTES - CAS 314045-39-1 - Calbiochem: のSDS（安全データシート）、CoA（試験成績書）およびCoQ（品質証明書）、カタログなど製品関連の技術資料を入手いただけます。

(M)SDS
参考資料
Data Sheet

同義語: N,Nʹ-(5,5ʹ-(2,2ʹ-Thiobis(ethane-2,1-diyl))bis(1,3,4-thiadiazole-5,2-diyl))bis(2-phenylacetamide), Kidney-Type Glutaminase Inhibitor II, GAC Inhibitor II, GLS1 Inhibitor II, KGA Inhibitor II

Primary Target: kidney-type glutaminase

View This Product on Sigma-Aldrich

お勧めの製品

概要

Replacement Information

主要スペック表

CAS #	Empirical Formula
314045-39-1	C₂₄H₂₄N₆O₂S₃

価格＆在庫状況

カタログ番号	在庫状況	包装	Qty/Pk	価格	数量
5.30030.0001	在庫状況検索中… — 現在国内在庫なし現在国内在庫有り販売中止在庫僅少現在国内在庫あり在庫を照会するにはログインしてください現在国内在庫有り現在国内在庫なし現在国内在庫有り Remaining : Will advise Remaining : Will advise 注文対象外お問合せください Contact Customer Service お問合せくださいお問合せください	ｶﾞﾗｽﾋﾞﾝ	10 mg	価格を検索中… 価格が見つかりません Minimum Quantity needs to be mulitiple of Maximum Quantity is 弊社照会詳細を表示　値引 () — 弊社照会納入価格を閲覧するにはログインしてください	在庫状況を照会 —	お気に入り/ショッピングリストに追加お気に入り/ショッピングリストに追加お気に入りに追加されました

Description
Overview	A cell-permeable bis-thiadiazole compound that selectively inhibits GLS1 (IC₅₀ = 60 and 80 nM, respectively, against hKGA and hGAC), but not the liver-type GLS2/LGA (IC₅₀ = 88 µM using hLGA) mitochondrial glutaminase (GA) activity by inducing an inactive GLS1 tetrameric conformation via a 2:1 inhibitor-to-tetramer stoichiometric binding. Shown to induce growth inhibition under aerobic/normoxic (up to 10 µM; 20% O₂) and cell death under hypoxic (2 µM; 3% O₂) in P493 B-cell lymphoma cultures in vitro and effectively suppress P493 tumor expansion in mice in vivo (12.5 mg/kg or 200 µg/animal via i.p.; q.o.d.).
Catalogue Number	530030
Brand Family	Calbiochem®
Synonyms	N,Nʹ-(5,5ʹ-(2,2ʹ-Thiobis(ethane-2,1-diyl))bis(1,3,4-thiadiazole-5,2-diyl))bis(2-phenylacetamide), Kidney-Type Glutaminase Inhibitor II, GAC Inhibitor II, GLS1 Inhibitor II, KGA Inhibitor II

References
References	Shukla, K., et al. 2012. J. Med. Chem. 55, 10551. Thangavelu, K., et al. 2012. Proc. Natl. Acad. Sci. USA 109, 7705. Le, A., et al. 2012. Cell Metab. 15, 110. DeLaBarre, B., et al. 2011. Biochemistry 50, 10764. Seltzer, M.J., et al. 2010. Cancer Res. 70, 8981. Robinson, M.M., et al. 2007. Biochem. J. 406, 407.

Product Information
CAS number	314045-39-1
Form	Yellow powder
Hill Formula	C₂₄H₂₄N₆O₂S₃
Chemical formula	C₂₄H₂₄N₆O₂S₃
Reversible	Y
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Primary Target	kidney-type glutaminase
Primary Target IC<sub>50</sub>	140 and 210 nM in HEK293 cells expressing wt-KGA and F318Y-cKGA, respectively
Purity	≥94% by HPLC

Physicochemical Information
Cell permeable	Y

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Standard Handling
Storage	-20°C
Protect from Light	Protect from light
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
カタログ番号	GTIN
5.30030.0001	04055977241198

Documentation

Glutaminase Inhibitor II, BPTES - CAS 314045-39-1 - Calbiochem (M)SDS

タイトル
英語版製品安全データシート（(M)SDS）

参考資料

参考資料の概要
Shukla, K., et al. 2012. J. Med. Chem. 55, 10551. Thangavelu, K., et al. 2012. Proc. Natl. Acad. Sci. USA 109, 7705. Le, A., et al. 2012. Cell Metab. 15, 110. DeLaBarre, B., et al. 2011. Biochemistry 50, 10764. Seltzer, M.J., et al. 2010. Cancer Res. 70, 8981. Robinson, M.M., et al. 2007. Biochem. J. 406, 407.

データシート

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	29-April-2014 JSW
Synonyms	N,Nʹ-(5,5ʹ-(2,2ʹ-Thiobis(ethane-2,1-diyl))bis(1,3,4-thiadiazole-5,2-diyl))bis(2-phenylacetamide), Kidney-Type Glutaminase Inhibitor II, GAC Inhibitor II, GLS1 Inhibitor II, KGA Inhibitor II
Description	A cell-permeable bis-thiadiazole compound that selectively inhibits GLS1 (IC₅₀ = 60 and 80 nM, respectively, against hKGA and hGAC), but not the liver-type GLS2/LGA (IC₅₀ = 88 µM using hLGA), mitochondrial glutaminase (GA) activity by inducing an inactive GLS1 tetrameric conformation via a 2:1 inhibitor-to-tetramer stoichiometric binding, non-competitive against glutamine or phosphate binding. B-cell lymphoma line P493 is shown to depend primarily on glutamine metabolism for survival under hypoxic condition and cellular GLS1 inhibtion by BPTES treatment results in cell death (2 µM BPTES & 3% O₂ for 4 d), while under aerobic/normoxic condition (20% O₂ and up to 10 µM BPTES for 4 d) only growth inhibition is observed. Likewise, intraperitoneal administration (12.5 mg/kg or 200 µg/animal; q.o.d.) is demonstrated to be efficacious in suppressing P493 tumor expansion in mice in vivo.
Form	Yellow powder
Intert gas (Yes/No)	Packaged under inert gas
CAS number	314045-39-1
Chemical formula	C₂₄H₂₄N₆O₂S₃
Structure formula
Purity	≥94% by HPLC
Solubility	DMSO (50 mg/ml)
Storage	Protect from light -20°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity	Standard Handling
References	Shukla, K., et al. 2012. J. Med. Chem. 55, 10551. Thangavelu, K., et al. 2012. Proc. Natl. Acad. Sci. USA 109, 7705. Le, A., et al. 2012. Cell Metab. 15, 110. DeLaBarre, B., et al. 2011. Biochemistry 50, 10764. Seltzer, M.J., et al. 2010. Cancer Res. 70, 8981. Robinson, M.M., et al. 2007. Biochem. J. 406, 407.

カテゴリー

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Proteases Inhibitors

製品がカートに追加されました