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345887 Ginkgolic Acid (15:1) - CAS 22910-60-7 - Calbiochem

Ginkgolic Acid (15:1), CAS 22910-60-7, is a cell-permeable analog of anacardic acid that inhibits protein SUMOylation (IC50 = 3.0 µM using RanGAP1-C2 as substrate) in an ATP-dependent manner.

Ginkgolic Acid (15:1) - CAS 22910-60-7 - Calbiochem: のSDS（安全データシート）、CoA（試験成績書）およびCoQ（品質証明書）、カタログなど製品関連の技術資料を入手いただけます。

同義語: (Z)-6-(Pentadec-8-enyl)-2-hydroxybenzoic acid, Histone Acetyltransferase Inhibitor VI, PCAF Inhibitor II, SUMOylation Inhibitor, HAT Inhibitor VI

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345887
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概要

主要スペック表

CAS #Empirical Formula
22910-60-7C₂₂H₃₄O₃

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      Description
      OverviewA cell-permeable anacardic acid (Cat. No. 172050) analog that inhibits protein SUMO (Cat. Nos. 662037, 662039, and 662042) modification (IC50 = 3.0 µM using RanGAP1-C2 as substrate) in an ATP-dependent manner by selectively targeting SUMO-activating enzyme E1 (Cat. Nos. 662073 and 662074) and interfering with E1-SUMO intermediate formation independent of E1 active site cysteine. Both ginkgolic acid and anacardic acid are shown to effectively decrease overall SUMOylation of 293T cellular proteins, including p53, in a dose-dependent manner, while neither compound is effective in affecting overall cellular protein ubiquitination or histone H4K8 acetylation in 293T cultures, although both compounds are shown to inhibit histone lysine acetylation by PCAF (Cat. No. 124026) in cell-free acetylase assays. Also available as a 25 mM solution in DMSO (Cat. No. 508197).
      Catalogue Number345887
      Brand Family Calbiochem®
      Synonyms(Z)-6-(Pentadec-8-enyl)-2-hydroxybenzoic acid, Histone Acetyltransferase Inhibitor VI, PCAF Inhibitor II, SUMOylation Inhibitor, HAT Inhibitor VI
      References
      ReferencesFukuda, I., et al. 2009. Chem. Biol. 16, 133.
      Product Information
      CAS number22910-60-7
      FormWhite solid
      Hill FormulaC₂₂H₃₄O₃
      Chemical formulaC₂₂H₃₄O₃
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      ApplicationGinkgolic Acid (15:1), CAS 22910-60-7, is a cell-permeable analog of anacardic acid that inhibits protein SUMOylation (IC50 = 3.0 µM using RanGAP1-C2 as substrate) in an ATP-dependent manner.
      Biological Information
      Purity≥98% by HPLC
      Safety Information
      R PhraseR: 36/37/38

      Irritating to eyes, respiratory system and skin.
      S PhraseS: 26

      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Irritant
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing intitial thaw, aliquot and freeze (-20°C).
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      カタログ番号 GTIN
      345887-5MGCN 04055977214543