数量	カタログ番号	注文内容	Qty/Pk	価格
			96-Well Plate

数量	カタログ番号	注文内容	Qty/Pk	価格
	48-602MAG	Buffer Detection Kit for Magnetic Beads	1 Kit

345834 Sigma-AldrichGenistein, Soybean - CAS 446-72-0 - Calbiochem

A cell-permeable, reversible, substrate competitive inhibitor of protein tyrosine kinases, including autophosphorylation of epidermal growth factor receptor kinase (IC₅₀ = 2.6 µM).

Genistein, Soybean - CAS 446-72-0 - Calbiochem: のSDS（安全データシート）、CoA（試験成績書）およびCoQ（品質証明書）、カタログなど製品関連の技術資料を入手いただけます。

(M)SDS
試験成績書（CoA）
参考資料
カタログ
Data Sheet
Citations

同義語: 4ʹ,5,7-Trihydroxyisoflavone

Primary Target: EGFR kinase

View This Product on Sigma-Aldrich

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概要

Replacement Information

主要スペック表

CAS #	Empirical Formula
446-72-0	C₁₅H₁₀O₅

価格＆在庫状況

カタログ番号	在庫状況	包装	Qty/Pk	価格	数量
345834-20MGCN	在庫状況検索中… — 現在国内在庫なし現在国内在庫有り販売中止在庫僅少現在国内在庫あり在庫を照会するにはログインしてください現在国内在庫有り現在国内在庫なし現在国内在庫有り Remaining : Will advise Remaining : Will advise 注文対象外お問合せください Contact Customer Service お問合せくださいお問合せください	ｶﾞﾗｽﾋﾞﾝ	20 mg	価格を検索中… 価格が見つかりません Minimum Quantity needs to be mulitiple of Maximum Quantity is 弊社照会詳細を表示　値引 () — 弊社照会納入価格を閲覧するにはログインしてください	在庫状況を照会 —	お気に入り/ショッピングリストに追加お気に入り/ショッピングリストに追加お気に入りに追加されました
345834-50MGCN	在庫状況検索中… — 現在国内在庫なし現在国内在庫有り販売中止在庫僅少現在国内在庫あり在庫を照会するにはログインしてください現在国内在庫有り現在国内在庫なし現在国内在庫有り Remaining : Will advise Remaining : Will advise 注文対象外お問合せください Contact Customer Service お問合せくださいお問合せください	樹脂ｱﾝﾌﾟﾙ	50 mg	価格を検索中… 価格が見つかりません Minimum Quantity needs to be mulitiple of Maximum Quantity is 弊社照会詳細を表示　値引 () — 弊社照会納入価格を閲覧するにはログインしてください	在庫状況を照会 —	お気に入り/ショッピングリストに追加お気に入り/ショッピングリストに追加お気に入りに追加されました

Description
Overview	A cell-permeable, reversible, substrate competitive inhibitor of protein tyrosine kinases, including autophosphorylation of epidermal growth factor receptor kinase (IC₅₀ = 2.6 µM). The inhibition is competitive with respect to ATP and non-competitive with respect to the phosphate acceptor. Has only a trivial effect on the activity of PKA and PKC (IC₅₀ > 350 µM). Inhibits tumor cell proliferation and induces tumor cell differentiation. Produces cell cycle arrest and apoptosis in Jurkat T-leukemia cells. However, it prevents anti-CD3 monoclonal antibody-induced thymic apoptosis. Also inhibits topoisomerase II activity in vitro.
Catalogue Number	345834
Brand Family	Calbiochem®
Synonyms	4ʹ,5,7-Trihydroxyisoflavone

References
References	Constantinou, A., and Huberman, E. 1995. Proc. Soc. Exp. Biol. Med. 208, 109. Wei, H., et al. 1995. Proc. Soc. Exp. Biol. Med. 208, 124. Wei, H., et al. 1995. Carcinogenesis 17, 73. Kobayashi, S., et al. 1994. J. Biol. Chem. 269, 9011. Migita, K., et al. 1994. J. Immunol. 153, 3457. Spinozzi, F., et al. 1994. Leuk. Res. 18, 431. Dhar, A., et al. 1990. Mol. Pharmacol. 37, 519. Hill, T.D., et al. 1990. Science 248, 1660. Dean, N.M., et al. 1989. Biochem. Biophys. Res. Commun. 165, 795. Akiyama, T., et al. 1987. J. Biol. Chem. 262, 5592.

References

Constantinou, A., and Huberman, E. 1995. Proc. Soc. Exp. Biol. Med. 208, 109.
Wei, H., et al. 1995. Proc. Soc. Exp. Biol. Med. 208, 124.
Wei, H., et al. 1995. Carcinogenesis 17, 73.
Kobayashi, S., et al. 1994. J. Biol. Chem. 269, 9011.
Migita, K., et al. 1994. J. Immunol. 153, 3457.
Spinozzi, F., et al. 1994. Leuk. Res. 18, 431.
Dhar, A., et al. 1990. Mol. Pharmacol. 37, 519.
Hill, T.D., et al. 1990. Science 248, 1660.
Dean, N.M., et al. 1989. Biochem. Biophys. Res. Commun. 165, 795.
Akiyama, T., et al. 1987. J. Biol. Chem. 262, 5592.

Product Information
CAS number	446-72-0
ATP Competitive	N
Form	White solid
Hill Formula	C₁₅H₁₀O₅
Chemical formula	C₁₅H₁₀O₅
Reversible	Y
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Primary Target	EGFR kinase
Primary Target IC<sub>50</sub>	2.6 µM against autophosphorylation of epidermal growth factor receptor kinase
Purity	≥95% by HPLC

Physicochemical Information
Cell permeable	Y

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS
RTECS	NR2392000

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Standard Handling
Storage	-20°C
Protect from Light	Protect from light
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Packaging Information

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
カタログ番号	GTIN
345834-20MGCN	04055977214376
345834-50MGCN	04055977214383

Documentation

Genistein, Soybean - CAS 446-72-0 - Calbiochem (M)SDS

タイトル
英語版製品安全データシート（(M)SDS）

Genistein, Soybean - CAS 446-72-0 - Calbiochem 試験成績書（CoA）

タイトル	ロット番号
345834	ロット番号を入力

参考資料

参考資料の概要
Constantinou, A., and Huberman, E. 1995. Proc. Soc. Exp. Biol. Med. 208, 109. Wei, H., et al. 1995. Proc. Soc. Exp. Biol. Med. 208, 124. Wei, H., et al. 1995. Carcinogenesis 17, 73. Kobayashi, S., et al. 1994. J. Biol. Chem. 269, 9011. Migita, K., et al. 1994. J. Immunol. 153, 3457. Spinozzi, F., et al. 1994. Leuk. Res. 18, 431. Dhar, A., et al. 1990. Mol. Pharmacol. 37, 519. Hill, T.D., et al. 1990. Science 248, 1660. Dean, N.M., et al. 1989. Biochem. Biophys. Res. Commun. 165, 795. Akiyama, T., et al. 1987. J. Biol. Chem. 262, 5592.

参考資料の概要

カタログ

タイトル
Caspases and other Apoptosis Related Tools Brochure

引用

Title

Weijian Shao, Roy C. Orlando and Mouhamed S. Awayda. (2005) Bisphosphonates stimulate an endogenous nonselective cation channel in Xenopus oocytes: potential mechanism of action. American Journal of Physiology Cell Physiology 289, C248-C256.

データシート

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	16-April-2010 JSW
Synonyms	4ʹ,5,7-Trihydroxyisoflavone
Description	A cell-permeable, reversible, substrate competitive inhibitor of protein tyrosine kinases, including autophosphorylation of epidermal growth factor receptor kinase (IC₅₀ = 2.6 µM). The inhibition is competitive with respect to ATP and non-competitive with respect to the phosphate acceptor. Inhibits tumor cell proliferation and induces tumor cell differentiation. Inhibits exogenous substrate phosphorylation by EGFR kinase and pp60^v-src with similar potencies (IC₅₀ = 20-25 µM). Has only a trivial effect on PKC and PKA (IC₅₀ >350 µM). Produces cell cycle arrest and apoptosis in Jurkat T-leukemia cells. Prevents anti-CD3 monoclonal antibody-induced thymic apoptosis. Also inhibits topoisomerase II activity in vitro. Blocks oxidative DNA damage in vitro.
Form	White solid
CAS number	446-72-0
RTECS	NR2392000
Chemical formula	C₁₅H₁₀O₅
Structure formula
Purity	≥95% by HPLC
Solubility	DMSO (200 mg/ml)
Storage	Protect from light -20°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity	Standard Handling
Merck USA index	14, 4391
References	Constantinou, A., and Huberman, E. 1995. Proc. Soc. Exp. Biol. Med. 208, 109. Wei, H., et al. 1995. Proc. Soc. Exp. Biol. Med. 208, 124. Wei, H., et al. 1995. Carcinogenesis 17, 73. Kobayashi, S., et al. 1994. J. Biol. Chem. 269, 9011. Migita, K., et al. 1994. J. Immunol. 153, 3457. Spinozzi, F., et al. 1994. Leuk. Res. 18, 431. Dhar, A., et al. 1990. Mol. Pharmacol. 37, 519. Hill, T.D., et al. 1990. Science 248, 1660. Dean, N.M., et al. 1989. Biochem. Biophys. Res. Commun. 165, 795. Akiyama, T., et al. 1987. J. Biol. Chem. 262, 5592.
Citation	Weijian Shao, Roy C. Orlando and Mouhamed S. Awayda. (2005) Bisphosphonates stimulate an endogenous nonselective cation channel in Xenopus oocytes: potential mechanism of action. American Journal of Physiology Cell Physiology 289, C248-C256.

カテゴリー

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Neurobiology / Neurodegeneration > Amyloidogenesis Inhibitors

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > Protein Tyrosine Kinase (PTK) Inhibitors

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