Millipore Sigma Vibrant Logo

361565 GSK3β Inhibitor XIX, IM-12 - Calbiochem

View This Product on Sigma-Aldrich
361565
価格&在庫状況を照会

概要

Replacement Information

主要スペック表

Empirical Formula
C₂₂H₂₀FN₃O₂

価格&在庫状況

カタログ番号 在庫状況包装 Qty/Pk 価格 数量
361565-10MGCN
在庫状況検索中…
現在国内在庫なし
現在国内在庫なし
現在国内在庫有り 
販売中止
在庫僅少
現在国内在庫あり
    Remaining : Will advise
      Remaining : Will advise
      注文対象外
      お問合せください
      Contact Customer Service

      ガラスビン 10 mg
      価格を検索中…
      価格が見つかりません
      Minimum Quantity needs to be mulitiple of
      Maximum Quantity is
      弊社照会 詳細を表示 
      値引
      ()
       
      弊社照会
      Description
      OverviewA cell-permeable indolylmaleimide derivative and SB-216763 analog that acts as a GSK-3β inhibitor, with an IC50 of 53 nM in an in vitro binding assay, compared with 92 nM for SB-216763 in the same assay condition, and reduces GSK-3β activity to 27% in an enzymatic assay at 3 µM concentration. It is shown to attenuate hNPC (human neural progenitor cells) cell proliferation, and enrich β-catenin around the nucleus of ST14 cells in the same extent of SB-216763. Furthermore, it can mimic the effect of stabilized β-catenin, up-regulates TCF-activity in a luciferase reporter gene assay, and enhances human progenitor cell differentiation.
      Catalogue Number361565
      Brand Family Calbiochem®
      SynonymsIM-12
      References
      ReferencesSchmole, AC., et al. 2010. Bioorg. Med. Chem. 18, 6785.
      Product Information
      FormOrange yellow powder
      Hill FormulaC₂₂H₂₀FN₃O₂
      Chemical formulaC₂₂H₂₀FN₃O₂
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥95% by HPLC
      Physicochemical Information
      SensitivityDMSO
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      カタログ番号 GTIN
      361565-10MGCN 04055977214239

      Documentation

      GSK3β Inhibitor XIX, IM-12 - Calbiochem (M)SDS

      タイトル

      英語版製品安全データシート((M)SDS) 

      GSK3β Inhibitor XIX, IM-12 - Calbiochem 試験成績書(CoA)

      タイトルロット番号
      361565

      参考資料

      参考資料の概要
      Schmole, AC., et al. 2010. Bioorg. Med. Chem. 18, 6785.
      データシート

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision23-February-2011 RFH
      SynonymsIM-12
      DescriptionA cell-permeable indolylmaleimide derivative and SB-216763 analog that acts as a GSK-3β inhibitor, with an IC50 of 53 nM in an in vitro binding assay, compared with 92 nM for SB-216763 in the same assay condition, and reduces GSK-3β activity to 27% in an enzymatic assay at 3 µM concentration. It is shown to attenuate hNPC (human neural progenitor cells) cell proliferation, and enrich β-catenin around the nucleus of ST14 cells in the same extent of SB-216763. Furthermore, it can mimic the effect of stabilized β-catenin, up-regulates TCF-activity in a luciferase reporter gene assay, and enhances human progenitor cell differentiation.
      FormOrange yellow powder
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₂₂H₂₀FN₃O₂
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (100 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesSchmole, AC., et al. 2010. Bioorg. Med. Chem. 18, 6785.