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364205 GM 6001 - CAS 142880-36-2 - Calbiochem

GM 6001, CAS 142880-36-2, is a potent, cell-permeable, broad-spectrum inhibitor of MMPs (Ki = 400 pM for MMP-1; 500 pM for MMP-2; 27 nM for MMP-3; 100 pM for MMP-8; and 200 pM for MMP-9).

GM 6001 - CAS 142880-36-2 - Calbiochem: のSDS（安全データシート）、CoA（試験成績書）およびCoQ（品質証明書）、カタログなど製品関連の技術資料を入手いただけます。

同義語: Galardin, N-[(2R)-2-(Hydroxamidocarbonylmethyl)-4-methylpentanoyl]-L-tryptophan Methylamide

Primary Target: MMP-1
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364205
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概要

Replacement Information

主要スペック表

CAS #Empirical Formula
142880-36-2C₂₀H₂₈N₄O₄

価格＆在庫状況

カタログ番号 在庫状況包装 Qty/Pk 価格 数量
364205-1MGCN
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      		 樹脂ｱﾝﾌﾟﾙ 1 mg
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      364205-5MGCN
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          		 樹脂ｱﾝﾌﾟﾙ 5 mg
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          Description
          OverviewA potent, cell-permeable, broad-spectrum hydroxamic acid inhibitor of matrix metalloproteinases (MMPs); (Ki = 400 pM for MMP-1; Ki = 500 pM for MMP-2; Ki = 27 nM for MMP-3; Ki = 100 pM for MMP-8; and Ki = 200 pM for MMP-9). Prevents the release of TNF-α in vivo and in vitro and abrogates endotoxin-induced lethality in mice. A 10 mM (1 mg/257 µl) solution of GM6001 (Cat. No. 364206) in DMSO is also available.
          Catalogue Number364205
          Brand Family Calbiochem®
          SynonymsGalardin, N-[(2R)-2-(Hydroxamidocarbonylmethyl)-4-methylpentanoyl]-L-tryptophan Methylamide
          References
          ReferencesSolorzano, C.C., et al. 1997. Shock 7, 427.
          Galardy, R.E., et al. 1994. Ann. NY Acad. Sci. 732, 315.
          Galardy, R.E., et al. 1994. Cancer Res. 54, 4715.
          Galardy, R.E. 1993. Drugs Future 18, 1109.
          Grobelny, D., et al. 1992. Biochemistry 31, 7152.
          Product Information
          CAS number142880-36-2
          ATP CompetitiveN
          FormOff-white solid
          Hill FormulaC₂₀H₂₈N₄O₄
          Chemical formulaC₂₀H₂₈N₄O₄
          ReversibleN
          Structure formula ImageStructure formula Image
          Quality LevelMQ100
          Applications
          ApplicationGM 6001, CAS 142880-36-2, is a potent, cell-permeable, broad-spectrum inhibitor of MMPs (Ki = 400 pM for MMP-1; 500 pM for MMP-2; 27 nM for MMP-3; 100 pM for MMP-8; and 200 pM for MMP-9).
          Biological Information
          Primary TargetMMP-1
          Primary Target K<sub>i</sub>400 pM for MMP-1; 500 pM for MMP-2; 27 nM for MMP-3; 100 pM for MMP-8; 200 pM for MMP-9
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications
          Global Trade Item Number
          カタログ番号 GTIN
          364205-1MGCN 04055977213744
          364205-5MGCN 04055977213799

          Documentation

          GM 6001 - CAS 142880-36-2 - Calbiochem (M)SDS

          タイトル

          英語版製品安全データシート（(M)SDS） 

          GM 6001 - CAS 142880-36-2 - Calbiochem 試験成績書（CoA）

          タイトルロット番号
          364205

          参考資料

          参考資料の概要
          Solorzano, C.C., et al. 1997. Shock 7, 427.
          Galardy, R.E., et al. 1994. Ann. NY Acad. Sci. 732, 315.
          Galardy, R.E., et al. 1994. Cancer Res. 54, 4715.
          Galardy, R.E. 1993. Drugs Future 18, 1109.
          Grobelny, D., et al. 1992. Biochemistry 31, 7152.

          引用

          Title
        • K. Fredriksson, et al. (2006) Red blood cells increase secretion of matrix metalloproteinases from human lung fibroblasts in vitro. American Journal of Physiology Lung Cellular and Molecular Physiology 290, L326-L333.
        • Anthony R. White, et al. (2006) Degradation of the alzheimer disease amyloid -peptide by metal-dependent up-regulation of metalloprotease activity. journal of Biological Chemistry 281, 17670-17680.
        • IM, E., et al. 2005. Molecular Biology of the Cell 16, 3488.
        • Daniel W. Lambert, et al. (2005) Tumor Necrosis Factor- Convertase (ADAM17) Mediates Regulated Ectodomain Shedding of the Severe-acute Respiratory Syndrome-Coronavirus (SARS-CoV) Receptor, Angiotensin-converting Enzyme-2 (ACE2). Journal of Biological Chemistry 280, 30113-30119.
        • Haili Su, et al. (2005) Noninvasive targeted imaging of matrix metalloproteinase activation in a murine model of postinfarction remodeling. Circulation 112, 3157-3167.
          		•
          データシート

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision07-April-2008 RFH
          SynonymsGalardin, N-[(2R)-2-(Hydroxamidocarbonylmethyl)-4-methylpentanoyl]-L-tryptophan Methylamide
          DescriptionA cell-permeable, potent broad-spectrum hydroxamic acid inhibitor of matrix metalloproteinases (MMPs). [Ki = 0.4 nM for skin fibroblast collagenase (MMP-1); Ki = 0.5 nM for gelatinase A (MMP-2); Ki = 27 nM for stromelysin (MMP-3); Ki = 0.1 nM for neutrophil collagenase (MMP-8); and Ki = 0.2 nM for gelatinase B (MMP-9)]. Also prevents the release of TNF-α in vivo and in vitro and abrogates endotoxin-induced lethality in mice.
          FormOff-white solid
          CAS number142880-36-2
          Chemical formulaC₂₀H₂₈N₄O₄
          Structure formulaStructure formula
          Purity≥95% by HPLC
          SolubilityDMSO (5 mg/ml)
          Storage -20°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Toxicity Standard Handling
          ReferencesSolorzano, C.C., et al. 1997. Shock 7, 427.
          Galardy, R.E., et al. 1994. Ann. NY Acad. Sci. 732, 315.
          Galardy, R.E., et al. 1994. Cancer Res. 54, 4715.
          Galardy, R.E. 1993. Drugs Future 18, 1109.
          Grobelny, D., et al. 1992. Biochemistry 31, 7152.
          Citation
        • K. Fredriksson, et al. (2006) Red blood cells increase secretion of matrix metalloproteinases from human lung fibroblasts in vitro. American Journal of Physiology Lung Cellular and Molecular Physiology 290, L326-L333.
        • Anthony R. White, et al. (2006) Degradation of the alzheimer disease amyloid -peptide by metal-dependent up-regulation of metalloprotease activity. journal of Biological Chemistry 281, 17670-17680.
        • IM, E., et al. 2005. Molecular Biology of the Cell 16, 3488.
        • Daniel W. Lambert, et al. (2005) Tumor Necrosis Factor- Convertase (ADAM17) Mediates Regulated Ectodomain Shedding of the Severe-acute Respiratory Syndrome-Coronavirus (SARS-CoV) Receptor, Angiotensin-converting Enzyme-2 (ACE2). Journal of Biological Chemistry 280, 30113-30119.
        • Haili Su, et al. (2005) Noninvasive targeted imaging of matrix metalloproteinase activation in a murine model of postinfarction remodeling. Circulation 112, 3157-3167.
          		•